TITLE

Combined Multilocus Sequence Typing and O Serogrouping Distinguishes Escherichia coli Subtypes Associated with Infant Urosepsis and/or Meningitis

AUTHOR(S)
Bidet, Philippe; Mahjoub-Messai, Farah; Blanco, Jorge; Blanco, Jesús; Dehem, Marie; Aujard, Yannick; Bingen, Edouard; Bonacorsi, Stéphane
PUB. DATE
July 2007
SOURCE
Journal of Infectious Diseases;7/15/2007, Vol. 196 Issue 2, p297
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The genetic relatedness of 223 invasive Escherichia coli strains that cause either meningitis or urosepsiswithout meningitis in young infants was determined by multilocus sequence typing (MLST), ribotyping, and phylogenetic polymerase chain reaction grouping. We also determined the serotypes and virulence genotypes (on the basis of 11 virulence genes). The strains belonged to 29 sequence type complexes (STc), 20 ribotypes, 26 O serogroups, and 39 virulence genotypes. MLST combined with O serogrouping identified 49 subtypes, or ‘sequence O types.’ Some sequence O types were almost exclusively associated with either urosepsis (STc27O2, STc27O6, and STc29O2) or meningitis (STc29O18). In contrast, STc29O45 was equally frequent in these 2 infection sites. Similarly, several virulence genotypes were specifically associated with one of these syndromes. These results point to the existence of specialized invasive subtypes that cause urosepsis or meningitis in infants and identify a new dually virulent invasive clone.
ACCESSION #
25812376

 

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