TITLE

Double-stranded DNA breaks and gene functions in recombination and meiosis

AUTHOR(S)
Wuxing Li; Hong Ma
PUB. DATE
May 2006
SOURCE
Cell Research;May2006, Vol. 16 Issue 5, p402
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Meiotic prophase I is a long and complex phase. Homologous recombination is an important process that occurs between homologous chromosomes during meiotic prophase I. Formation of chiasmata, which hold homologous chromosomes together until the metaphase I to anaphase I transition, is critical for proper chromosome segregation. Recent studies have suggested that the SPO11 proteins have conserved functions in a number of organisms in generating sites of double-stranded DNA breaks (DSBs) that are thought to be the starting points of homologous recombination. Processing of these sites of DSBs requires the function of RecA homologs, such as RAD51, DMC1, and others, as suggested by mutant studies; thus the failure to repair these meiotic DSBs results in abnormal chromosomal alternations, leading to disrupted meiosis. Recent discoveries on the functions of these RecA homologs have improved the understanding of the mechanisms underlying meiotic homologous recombination.Cell Research (2006) 16: 402–412. doi:10.1038/sj.cr.7310052; published online 15 May 2006
ACCESSION #
25801003

 

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