TITLE

The hunt for cancer-initiating cells: a history stemming from leukemia

AUTHOR(S)

Buzzeo, M. P.; Scott, E. W.; Cogle, C. R.

PUB. DATE

August 2007

SOURCE

Leukemia (08876924);Aug2007, Vol. 21 Issue 8, p1619

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Conventional cancer therapies are plagued by disease relapses due to incomplete eradication of cancer-initiating cells. Evidence for cancer-initiating cells originally arose from studies in hematology and leukemia. Lessons learned from hematopoietic stem cells laid the bedrock for understanding how leukemic cells self-renew and remain in immature states. Decades later, leukemia-initiating cell techniques are now being applied to the field of solid tumors such as brain, breast, bone, colon, pancreas, lung and prostate cancer, with several cancer-initiating cell efforts led by hematologists. Different isolation techniques enriching for primitive cancer-initiating cells have been developed and are described in this review. Although the concept of cancer-initiating cells arose from studies in normal tissue stem cells, differences exist between neoplastic-initiating clones and their normal counterparts. Several efforts have uncovered aberrant molecular pathways and niche interactions unique to cancer-initiating cells. Efforts to exploit these pathways and interactions could ultimately lead to complete eradication of cancers.Leukemia (2007) 21, 1619�1627; doi:10.1038/sj.leu.2404768; published online 31 May 2007

ACCESSION #

25791510

Tags: CANCER -- Treatment;  BONE marrow cells;  HEMATOPOIETIC stem cells;  HEMATOLOGY;  LEUKEMIA;  BLOOD cells;  STEM cells

 

Related Articles

• DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification. Gar�on, L.; Libura, M.; Delabesse, E.; Valensi, F.; Asnafi, V.; Berger, C.; Schmitt, C.; Leblanc, T.; Buzyn, A.; Macintyre, E. // Leukemia (08876924);Aug2005, Vol. 19 Issue 8, p1338 

  The t(6;9)(p23;q34) is a recurrent chromosomal abnormality observed in 1% of acute myelogenous leukemia (AML), which generates a fusion transcript between DEK and CAN/NUP214 genes. We used a DEK-CAN real-time quantitative (RQ)-PCR strategy to analyze 79 retrospective and prospective samples from...

• Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Wei Guo; Lasky, Joseph L.; Chun-Ju Chang; Mosessian, Sherly; Xiaoman Lewis; Yun Xiao; Yeh, Jennifer E.; Chen, James Y.; Iruela-Arispe, M. Luisa; Varella-Garcia, Marileila; Hong Wu // Nature;5/22/2008, Vol. 453 Issue 7194, p529 

  Cancer stem cells, which share many common properties and regulatory machineries with normal stem cells, have recently been proposed to be responsible for tumorigenesis and to contribute to cancer resistance. The main challenges in cancer biology are to identify cancer stem cells and to define...

• Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. Pelus, L. M.; Fukuda, S. // Leukemia (08876924);Mar2008, Vol. 22 Issue 3, p466 

  Stem cell research is currently focused on totipotent stem cells and their therapeutic potential, however adult stem cells, while restricted to differentiation within their tissue or origin, also have therapeutic utility. Transplantation with bone marrow hematopoietic stem cells (HSC) has been...

• ALLO Transplants And Second Malignancies. Ershler, William B. // Clinical Oncology Alert;Mar2007, Vol. 23 Issue 3, p21 

  The risk for solid tumor development in prior recipients of allogeneic hematopoietic stem cells at the Leukemia/Bone Marrow Transplantation Program of British Columbia was found to be 3.1% at ten years of follow up. Older recipients (40 years and older) and those who received their graft from...

• Leukemia-Initiating Cells (L-IC). Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p377 

  A definition of the term "leukemia-initiating cells (L-IC)" is presented. It refers to the hematopoietic stem cells of the leukemia. Only a small portion of all leukemic cells can self-renew in an organism. The incidence of L-IC subfraction in human is lower than the incidence of normal...

• Mothers' Perceptions of Benefit Following Pediatric Stem Cell Transplantation: A Longitudinal Investigation of the Roles of Optimism, Medical Risk, and Sociodemographic Resources. Rini, Christine; Manne, Sharon; Duhamel, Katherine N.; Austin, Jane; Ostroff, Jamie; Boulad, Farid; Parsons, Susan K.; Martini, Richard; Williams, Sharon E.; Mee, Laura; Sexson, Sandra; Redd, William H. // Annals of Behavioral Medicine;2004, Vol. 28 Issue 2, p132 

  Background: This longitudinal study investigated the course and predictors of benefit finding among 144 mothers of children undergoing hematopoietic stem cell transplantation (HSCT), a severely stressful and life-threatening medical procedure. Purpose: Children's medical risk and mothers'...

• SHORT TANDEM REPEAT TECHNOLOGY HAS DIVERSE APPLICATIONS: INDIVIDUAL IDENTIFICATION, PHYLOGENETIC RECONSTRUCTION AND CHIMERISM BASED POST HAEMATOPOIETIC STEM CELL TRANSPLANTATION GRAFT MONITORING. Agrawal, Suraksha; Khan, Faisal; Talwar, Sudha; Nityanand, Sonia // Indian Journal of Medical Sciences;Jul2004, Vol. 58 Issue 7, p297 

  BACKGROUND: Short Tandem Repeat (STR) loci are widely considered to be effective for variety of applications including forensic applications, phylogenetic reconstruction and chimerism based post Haematopoietic Stem Cell Transplantation (HSCT) graft monitoring. For each application, specific sets...

• Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Ott, Marion G.; Schmidt, Manfred; Schwarzwaelder, Kerstin; Stein, Stefan; Siler, Ulrich; Koehl, Ulrike; Glimm, Hanno; K�hlcke, Klaus; Schilz, Andrea; Kunkel, Hana; Naundorf, Sonja; Brinkmann, Andrea; Deichmann, Annette; Fischer, Marlene; Ball, Claudia; Pilz, Ingo; Dunbar, Cynthia; Yang Du; Jenkins, Nancy A.; Copeland, Neal G. // Nature Medicine;Apr2006, Vol. 12 Issue 4, p401 

  Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received gene therapy after nonmyeloablative bone marrow conditioning for the treatment of X-linked chronic granulomatous disease...

• Use of Human Embryonic Stem Cells to Understand Hematopoiesis and Hematopoietic Stem Cell Niche. Islam, Mohammad Saiful; Ni, Zhenya; Kaufman, Dan S. // Current Stem Cell Research & Therapy;Sep2010, Vol. 5 Issue 3, p245 

  Intensive research of hematopoiesis using human embryonic stem cells (hESC) as a unique starting cell population has enabled differentiation and isolation of diverse hematopoietic cell lineages. However, there has been only limited success in derivation of hematopoietic stem cells (HSCs) capable...

Read the Article