TITLE

Multimodal HPLC Screening of Polysaccharide-based Chiral Stationary Phases

AUTHOR(S)
Huybrechts, Tom; Török, Gabriella; Vennekens, Tom; Sneyers, Rudy; Vrielynck, Sara; Somers, Ivan
PUB. DATE
June 2007
SOURCE
LC-GC Europe;Jun2007, Vol. 20 Issue 6, p320
SOURCE TYPE
Trade Publication
DOC. TYPE
Article
ABSTRACT
High-performance liquid chromatography (HPLC) is a powerful tool for the enantioselective separation of chiral drugs. However, the selection of an appropriate chiral stationary phase (CSP) and suitable operating conditions is a bottleneck in method development and a time- and resource-consuming task. Multimodal screening of a small number of CSPs with broad enantiorecognition abilities has been recognized as the best strategy to achieve rapid and reliable separations of chiral compounds. This paper describes the generic screening strategy developed at Johnson & Johnson Pharmaceutical Research and Development (J&J PRD) to successfully develop enantioselective HPLC methods for chiral molecules of pharmaceutical interest.
ACCESSION #
25775331

 

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