TITLE

Decline in lung function and mortality: implications for medical monitoring

AUTHOR(S)
Sircar, Kanta; Hnizdo, Eva; Petsonk, Edward; Attfield, Michael
PUB. DATE
July 2007
SOURCE
Occupational & Environmental Medicine;Jul2007, Vol. 64 Issue 7, p461
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: To investigate the risk of death associated with selected cut-off points for rate of decline of forced expiratory volume in one second (FEY1). Methods: Mortality rates of a cohort of 1730 coal miners who had performed two pulmonary function tests 12.8 years apart were followed up for an additional 12 years. Based on previous studies, cut-off points for FEV1 rate of decline (ml/year) were selected as 30, 60 and 90 ml/year. Cox proportional hazard regression was used to estimate multivariate risk ratio of death in each category. Results: The risk ratios (compared to ‘below 30 mI/year’) were 1.39 (95% CI 0.99 to 1.97) in the ‘60 to less than 90 mI/year’ category and 1.90 (95% CI 1.32 to 2.76) in the ‘90 ml/year and above’ category. Rates of decline above 90 ml/year were consistently related to excess mortality. In non-smokers and those with neither restrictive nor obstructive patterns at the first survey, rates of decline above 60 ml/year were significantly associated with decreased mortality. Conclusions: Risk of death increases in individuals with rates of decline above about 60 mI/year and is statistically significant with declines of 90 mI/year or more. These results should be useful to healthcare providers in assessing lung function declines observed in individuals.
ACCESSION #
25724963

 

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