Decline in lung function and mortality: implications for medical monitoring

Sircar, Kanta; Hnizdo, Eva; Petsonk, Edward; Attfield, Michael
July 2007
Occupational & Environmental Medicine;Jul2007, Vol. 64 Issue 7, p461
Academic Journal
Aim: To investigate the risk of death associated with selected cut-off points for rate of decline of forced expiratory volume in one second (FEY1). Methods: Mortality rates of a cohort of 1730 coal miners who had performed two pulmonary function tests 12.8 years apart were followed up for an additional 12 years. Based on previous studies, cut-off points for FEV1 rate of decline (ml/year) were selected as 30, 60 and 90 ml/year. Cox proportional hazard regression was used to estimate multivariate risk ratio of death in each category. Results: The risk ratios (compared to ‘below 30 mI/year’) were 1.39 (95% CI 0.99 to 1.97) in the ‘60 to less than 90 mI/year’ category and 1.90 (95% CI 1.32 to 2.76) in the ‘90 ml/year and above’ category. Rates of decline above 90 ml/year were consistently related to excess mortality. In non-smokers and those with neither restrictive nor obstructive patterns at the first survey, rates of decline above 60 ml/year were significantly associated with decreased mortality. Conclusions: Risk of death increases in individuals with rates of decline above about 60 mI/year and is statistically significant with declines of 90 mI/year or more. These results should be useful to healthcare providers in assessing lung function declines observed in individuals.


Related Articles

  • Spirometry -- training, technique and equipment. Cooper, Brendan // Practice Nurse;3/23/2007, Vol. 33 Issue 6, p37 

    The article discusses training, technique and equipment in spirometry. Spirometry may be a well-established measurement, but essential components of a spirometry service are attention to preparation and maintenance of the equipment and adequate performance of the technique. Achieving competence...

  • Using Spirometry to Rule Out Restriction in Patients with Concomitant Low Forced Vital Capacity and Obstructive Pattern. Khalid, Imran; Morris, Zachary Q.; Khalid, Tabindeh J; Nisar, Amina; DiGiovine, Bruno // Open Respiratory Medicine Journal;2011, Vol. 5, p44 

    Background: Different formulas have been proposed to exclude restriction based on spirometry, however none of them have specifically tested the patients whose spirometry show both obstruction and a low forced vital capacity (FVC). Study Objective: The study was designed to create an algorithm...

  • Diaphragm plication following phrenic nerve injury. Wijkstra, P.J.; Meijer, P.M.; Meinesz, A.F. // Thorax;May2003, Vol. 58 Issue 5, p460 

    Comments on the plication of the diaphragm following phrenic nerve injury. Omission of the assessment of vital capacity in both sitting and supine positions; Helpfulness of pulmonary function tests in combination with quantitative perfusion scans in the diagnosis of patients with diaphragmatic...

  • A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis. Yong Huang; Shwu-Fan Ma; Rekha Vij; Oldham, Justin M.; Herazo-Maya, Jose; Broderick, Steven M.; Strek, Mary E.; White, Steven R.; Hogarth, D. Kyle; Sandbo, Nathan K.; Lussier, Yves A.; Gibson, Kevin F.; Kaminski, Naftali; Garcia, Joe G. N.; Noth, Imre; Huang, Yong; Ma, Shwu-Fan; Vij, Rekha // BMC Pulmonary Medicine;11/21/2015, Vol. 15, p1 

    Background: The course of disease for patients with idiopathic pulmonary fibrosis (IPF) is highly heterogeneous. Prognostic models rely on demographic and clinical characteristics and are not reproducible. Integrating data from genomic analyses may identify novel prognostic models...

  • A Cross Sectional Analysis of the Role of the Antimicrobial Peptide Cathelicidin in Lung Function Impairment within the ALIVE Cohort. Lambert, Allison A.; Kirk, Gregory D.; Astemborski, Jacquie; Neptune, Enid R.; Mehta, Shruti H.; Wise, Robert A.; Drummond, M. Bradley // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Background: Vitamin D deficiency is associated with reduced lung function. Cathelicidin, an antimicrobial peptide regulated by vitamin D, plays a role within the innate immune system. The association of cathelicidin with lung function decrement and respiratory infection is undefined. We...

  • Variability In The Interpretation Of Pulmonary Function Tests. Upadhyay, Daya; Rosen, M.D., Glenn D.; Jain, Manu; Corbridge, Thomas C. // Internet Journal of Pulmonary Medicine;2007, Vol. 7 Issue 1, p4 

    Pulmonary function tests (PFTs) interpretations can vary among pulmonologists although several guidelines are available to facilitate interpretation of the raw data. We designed a study to determine the degree of agreement in the interpretation of PFTs. This study was a survey by mail. Five PFTs...

  • Assessing lung function and respiratory health in schoolchildren as a means to improve local environmental conditions. Hutter, Hans-Peter; Borsoi, Livia; Wallner, Peter; Moshammer, Hanns; Kundi, Michael // Journal of Public Health Policy;2009, Vol. 30 Issue 2, p144 

    In response to the World Health Organization Children's Environment and Health Action Plan for Europe (CEHAPE), a town near Vienna initiated a health survey of schoolchildren. To create recommendations for the community's decision makers, the health survey tried to identify the environmental...

  • Lung function after preterm birth: development from mid-childhood to adulthood. Vollsæter, Maria; Røksund, Ola Drange; Eide, Geir Egil; Markestad, Trond; Halvorsen, Thomas // Thorax;Aug2013, Vol. 68 Issue 8, p767 

    Background: As a result of advances in perinatal care, more small preterm infants survive. There are concerns that preterm birth and its treatments may harm pulmonary development and thereby lead to chronic airway obstruction in adulthood. Objective: To assess the development of spirometric lung...

  • Both Pre-Transplant and Early Post-Transplant Antireflux Surgery Prevent Development of Early Allograft Injury After Lung Transplantation. Lo, Wai-Kit; Goldberg, Hilary; Wee, Jon; Fisichella, P.; Chan, Walter; Goldberg, Hilary J; Fisichella, P Marco; Chan, Walter W // Journal of Gastrointestinal Surgery;Jan2016, Vol. 20 Issue 1, p111 

    Background: Antireflux surgery (ARS) has been associated with improved lung transplant outcomes. Pre-transplant ARS has been shown in small studies to improve pulmonary function among transplant candidates with gastroesophageal reflux disease (GERD). Although early post-transplant...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics