TITLE

Effect of Processing Variables on Dissolution and Solubility of Piroxicam: Hydroxypropyl-β-Cyclodextrin Inclusion Complexes

AUTHOR(S)
Doijad, R. C.; Kanakal, M. M.; Manvi, F. V.
PUB. DATE
March 2007
SOURCE
Indian Journal of Pharmaceutical Sciences;2007, Vol. 69 Issue 2, p323
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Influence of processing variables on the solid-state of a model drug, piroxicam in cyclodextrin-based system and its effect on dissolution behavior of the drug was investigated in the present study. Binary systems containing piroxicam and hydroxypropyl-β-cyclodextrin prepared by various processes, were characterized by FTIR, thermal stability, photo stability and dissolution studies. Hydroxypropyl-β-cyclodextrin enhanced the solubility of piroxicam and increased dissolution rates from the binary systems. The complex prepared by co-evaporation method was found to yield better dissolution rate and stability as characterized in present study over those of the complex prepared by other methods.
ACCESSION #
25690802

 

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