TITLE

Precision genome surgery

AUTHOR(S)
Pingoud, Alfred; Silva, George H.
PUB. DATE
July 2007
SOURCE
Nature Biotechnology;Jul2007, Vol. 25 Issue 7, p743
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which examines the potential of zinc finger nucleases (ZFNs) for gene therapy. It is noted that ZFNs allows allow one to cleave DNA at a chosen target sequence. They also cleave prolifically at off-target sites, resulting in unacceptable toxicity. Moreover, the goal of gene therapy is to repair gene defects without otherwise modifying the genome.
ACCESSION #
25681889

 

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