TITLE

Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion

AUTHOR(S)
Singh, Vijay P.; Bhagat, Lakshmi; Navina, Sarah; Sharif, Rifat; Dawra, Rajinder K; Saluja, Ashok K.
PUB. DATE
July 2007
SOURCE
Gut;Jul2007, Vol. 56 Issue 7, p958
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Protease-activated receptor-2 (PAR-2) is present in the pancreas, where it has been shown to play a protective role during pancreatitis. However, the mechanism by which it protects against pancreatitis still remains to be elucidated. Acute pancreatitis is associated with premature zymogen activation and a blockage in digestive enzyme secretion. Aim: To examine the effects of PAR-2 activation on the severity of pancreatitis, and to determine whether its protective effects are mediated by affecting either premature activation or secretory blockage, or both. Results: The results confirmed that PAR-2 -/- mice have more severe pancreatitis than wild-type mice. Interestingly, intrapancreatic trypsin levels in the PAR-2 knockouts remained high after 6 h of pancreatitis, whereas they reverted to normal in the wild types. During pancreatitis, PAR-2 mRNA levels were upregulated in wild-type mice in response to supramaximal caerulein administration. Further, after a single injection of supramaximal caerulein, PAR-2 mRNA levels were also elevated, reaching a peak at 3 h. Stimulating PAR-2 with trypsin or the PAR-2-activating peptide, serine-leucine-isaleucine-glycine-arginine-leucine (SLIGRL), induced significantly more secretion from the acini of these caerulein-sensitised mice compared with the controls. PAR-2 activation also reversed the inhibition of secretion observed in both the caerulein and arginine models. Conclusions: Trypsin released during the early stages of pancreatitis activates PAR-2 receptors on the acinar cells and stimulates secretion from these cells. Thus, PAR-2 activation may decrease pancreatic injury and limit the severity of pancreatitis by allowing extracellular trypsin to act as a secretagogue.
ACCESSION #
25602403

 

Related Articles

  • The Diagnostic Significance of Excretory Pancreatic Tests. Bondar, Z. A.; Tuzhilin, S. A. // American Journal of Gastroenterology;Dec1974, Vol. 62 Issue 6, p488 

    The following four pathologic types of external pancreatic secretion are described in patients with chronic pancreatitis: obstruction, both distal and proximal block of secretion, hypo- and hypersecretory types. These pathologic types of external pancreatic secretion help to evaluate the level...

  • pancreatic function test.  // Taber's Cyclopedic Medical Dictionary;2005, p1578 

    A definition of the medical term "pancreatic function test" is presented. It refers to a test for the exocrine function of the pancreas, that is, the production of pancreatic juice. The definition is from the "Taber's Cyclopedic Medical Dictionary," published by F.A. Davis Co.

  • Exocrine Pancreatic Hypersecretion in Brazilian Alcoholics. Neves, Manoel M.; Borges, Durval R.; Vilela, Moacyr P. // American Journal of Gastroenterology;Aug1983, Vol. 78 Issue 8, p513 

    Thirty percent of alcoholic patients without clinical evidence of pancreatic or hepatic disease showed hypersecretion of pancreatic bicarbonate in all three test periods after stimulation with secretin and secretin-cholecystokinin, and an increased amount of protein in the duodenal aspirate of...

  • Practice Guidelines in Acute Pancreatitis. Banks, Peter A.; Freeman, Martin L. // American Journal of Gastroenterology;Oct2006, Vol. 101 Issue 10, p2379 

    The article focuses on the guidelines for diagnosing and treating acute pancreatitis. There are three important phases of pathophysiology of acute pancreatitis. The first phase consists of premature activation of trypsin within pancreatic acinar cells. In the second phase, there is...

  • Duodenal application of Li+ in a submaximal therapeutic dose inhibits exocrine pancreatic secretion and modulates gastro-duodenal myoelectrical activity in a conscious pig model. Naughton, Violetta; Hedemann, Mette S.; Naughton, Patrick J.; McSorley, Emeir; Laerke, Helle N. // Canadian Journal of Physiology & Pharmacology;Sep2013, Vol. 91 Issue 9, p764 

    This study tested whether duodenal application of lithium inhibits gastroduodenal motility, and whether it suppresses secretion from the exocrine pancreas. Five suckling pigs, 16-18 days old, were surgically fitted with 3 serosal electrodes on the wall of the gastric antrum and the duodenum for...

  • Cellular Alchemy.  // Diabetes Forecast;Dec2008, Vol. 61 Issue 12, p22 

    The article offers information on the research conducted regarding the conversion of non-insulin-making adult cells into insulin producers in mice in the U.S. It mentions that scientists were able to reprogram pancreatic exocrine cells by infecting them with viruses that were loaded with three...

  • Non-invasive quantification of pancreatic exocrine function using secretin-stimulated MRCP. Punwani, S.; Gillams, A.; Lees, W. // European Radiology;Feb2002, Vol. 13 Issue 2, p273 

    Our objective was to quantify water volume using magnetic resonance cholangiopancreatography (MRCP) sequences and apply this to secretin-stimulated studies with the aim of quantifying pancreatic exocrine function. A commercially available single-shot MRCP sequence was used in conjunction with a...

  • Epigenomic plasticity enables human pancreatic α to β cell reprogramming. Bramswig, Nuria C.; Everett, Logan J.; Schug, Jonathan; Dorrell, Craig; Chengyang Liu; Yanping Luo; Streeter, Philip R.; Naji, Ali; Grompe, Markus; Kaestner, Klaus H. // Journal of Clinical Investigation;Mar2013, Vol. 123 Issue 3, p1275 

    Insulin-secreting ß cells and glucagon-secreting a cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α,...

  • The Role of Minor Pancreatic Exocrine Deficiency in Digestive Disorders: A Review. Dreiling, David A. // American Journal of Gastroenterology;Nov1983, Vol. 78 Issue 11, p732 

    Discusses the role of functional pancreatic deficiency in observed digestive complaints. Types of secretion produced by the exocrine parenchyma; Conditions that could induce pancreatic digestive deficiency; Problem with assessing the contribution of minor or minimal pancreatic exocrine...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics