TITLE

Complex roles of cyclo-oxygenase 2 in hepatitis

AUTHOR(S)
Hoit, Andrew P.; Adams, David H.
PUB. DATE
July 2007
SOURCE
Gut;Jul2007, Vol. 56 Issue 7, p903
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article comments on a paper which examines the roles of cyclo-oxygenase 2 (COX2) in hepatitis. The authors stress that this study suggests that COX2 is directly implicated in hepatitis. They mention some findings of the study that warrant further examination. They emphasize that in the presence of high COX2 activity, initial hepatitis may fail to progress.
ACCESSION #
25602393

 

Related Articles

  • Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis. Yu, Jun; Hui, Alex Y.; Chu, Eagle S. H.; Cheng, Alfred S. L.; Go, Minnie Y. Y.; Chan, Henry L. Y.; Leung, Wai K.; Cheung, Kin F.; Ching, Arthur K. K.; Chui, Yiu L.; Chan, Ka K.; Sung, Joseph J. Y. // Gut;Jul2007, Vol. 56 Issue 7, p991 

    Background: It has been proved that cyclo-oxygenase-2 (COX-2) is rapidly induced by inflammatory mediators. However, it is not known whether overexpression of COX-2 in the liver is sufficient to promote activation or secretion of inflammatory factors leading to hepatitis. Aim: To investigate the...

  • The Significance of COX-2 and COX-2 Inhibitors in Liver Fibrosis and Liver Cancer. Cheng, Jidong; Hada, Toshikazu // Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy A;Apr2005, Vol. 4 Issue 2, p199 

    Hepatitis, liver cirrhosis and liver cancer are major liver diseases particularly in Asia. Liver cancer is also one of the leading cancers causing death in the world. Cyclooxygenase 2 (COX-2) is a highly inducible and key rate-limiting enzyme involved in the production of prostaglandins (PGs),...

  • FDA committees to review COX-2 inhibitor risk-benefit profile.  // Formulary;Feb2005, Vol. 40 Issue 2, p42 

    Reports on the plan of the U.S. Food and Drug Administration Arthritis Drugs and Drug Safety and Risk Management Advisory committees to review the risk-benefit profile of COX-2. Gastrointestinal protective claims in COX-2 labeling; Pressure to review cardiovascular effect of COX-2.

  • The Second Generation of COX-2 Inhibitors: What Advantages Do the Newest Offer? Stichtenoth, D.O.; Frölich, J.C. // Drugs;2003, Vol. 63 Issue 1, p33 

    The discovery of two cyclooxygenase (COX)-isoenzymes, a constitutive COX-1, serving homeostatic prostanoid synthesis, and an inducible COX-2, responsible for proinflammatory prostanoid production, led to the development of new non-steroidal anti-inflammatory drugs (NSAIDs), the selective COX-2...

  • Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylationassociated Recruitment of Transcription Factors to the Promoter. Xin Yue; Fang Yang; Yongbo Yang; Yongxin Mu; Wei Sun; Wei Li; Dongping Xu; Jianguo Wu; Ying Zhu // Virology Journal;2011, Vol. 8 Issue 1, p118 

    Background: The hepatitis B virus (HBV) is a major etiological factor of inflammation and damage to the liver resulting in hepatocellular carcinoma. Transcription factors play important roles in the disordered gene expression and liver injury caused by HBV. However, the molecular mechanisms...

  • Serum Lactic Dehydrogenase and Its Isoenzymes in Hepatic Disorders. Ramdeo, I. N.; Joshi, K. C. // American Journal of Gastroenterology;May1971, Vol. 55 Issue 5, p459 

    Examines the levels of lactic dehydrogenase and its isoenzymes with other conventional enzymes in chronic and acute hepatic disorders. Methodology of the study; Grades of derangement of liver function tests; Values of serum enzymes.

  • The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor. Sarapa, Nenad; Britto, Margaret R.; Mainka, Michelle B.; Parivar, Kourosh // European Journal of Clinical Pharmacology;Jun2005, Vol. 61 Issue 4, p247 

    Purpose: This study evaluated the effects of varying degrees of hepatic impairment on the pharmacokinetics and safety of valdecoxib following single and multiple dosing. Methods: This was an open-label, randomised, parallel group study in 12 subjects with mild hepatic impairment (Child-Pugh...

  • The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies. Sobolewski, Cyril; Cerella, Claudia; Dicato, Mario; Ghibelli, Lina; Diederich, Marc // International Journal of Cell Biology;2010, Vol. 2010, p1 

    It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis. The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin...

  • Cyclooxygenase-2 (COX-2) in acute myocardial infarction: cellular expression and use of selective COX-2 inhibitor. Saito, Takayuki; Rodger, Ian W.; Shennib, Hani; Hu, Fu; Tayara, Lara; Giaid, Adel // Canadian Journal of Physiology & Pharmacology;Feb2003, Vol. 81 Issue 2, p114 

    Provides information on a study that determined the cellular expression of the enzyme in the setting of acute myocardial infarction and the role of COX-2 in experimental animals using a selective COX-2 inhibitor. Methodology of the study; Results and discussion on the study; Conclusion.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics