Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration

Pijnenburg, Y. A. L.; Schoonenboom, S. N. M.; Mehta, P. D.; Mehta, S. P.; Mulder, C.; Veerhuis, R.; Blankenstein, M. A.; Scheltens, P.
July 2007
Journal of Neurology, Neurosurgery & Psychiatry;Jul2007, Vol. 78 Issue 7, p735
Academic Journal
The role of amyloid metabolism in the pathophysiology of frontotemporal lobar degeneration (FTLD) has yet to be elucidated. We compared CSF levels of amyloid beta 1-40 (Aβ40) and amyloid beta 1-42 (Aβ42) in patients with FTLD (n = 21) versus patients with Alzheimer's disease (AD, n = 39) and in control subjects (n = 30). While in AD cases Aβ42 levels were lower and CSF Aβ40 levels equal to those in controls, a significant decrease in Aβ40 and increase in the CSF Aβ42/Aβ40 ratio was observed in FTLD compared with AD and control subjects. These findings favour a differential involvement of amyloid β peptides in FTLD compared with AD.


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