TITLE

Neuroimaging findings in human prion disease

AUTHOR(S)
Macfarlane, R. G.; Wroe, S. J.; Collinge, J.; Yousry, T. A.; Jäger, H. R.
PUB. DATE
July 2007
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Jul2007, Vol. 78 Issue 7, p664
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Imaging occupies an important role in the investigation of dementia and neurodegenerative disease. The role of imaging in prion disease used to be one of exclusion of other conditions. Over the past decade, the non-invasive nature of MRI, the improved range of magnetic resonance sequences and the availability of clinical and neuropathological correlation have led to a more prominent position of MRI and its inclusion in the diagnostic criteria for variant Creutzfeldt—Jakob disease. As experience of imaging in human prion disease increases, patterns of change related to strain and genotype may improve the diagnostic potential of imaging in the future, may reduce the need for more invasive testing and prove useful in future therapeutic trials. This paper reviews the current knowledge of imaging appearances in human prion disease.
ACCESSION #
25595749

 

Related Articles

  • CREUZFELDT-JAKOB'S DISEASE — CASE REPORT. Cofoian-Amet, Z.; Rusu, B.; Mitu, C.; Roşianu, E.; Popescu, B. O. // Romanian Journal of Neurology;2014, Vol. 13 Issue 1, p39 

    Creutzfeldt-Jakob disease is a low incidence progressive neurodegenerative disorder and, meanwhile, the most frequent human prion disease. We report here the case of a 65 years old female with a 2-month history of rapidly progressive dementia. The clinical examination identified patent...

  • Early detection of sporadic CJD by diffusion-weighted MRI before the onset of symptoms. Satoh, Katsuya; Nakaoke, Ryota; Nishiura, Yoshihiro; Tsujino, Akira; Motomura, Masakatsu; Yoshimura, Toshirou; Sasaki, Kensuke; Shigematsu, Kazuto; Shirabe, Susumu; Eguchi, Katsumi // Journal of Neurology, Neurosurgery & Psychiatry;Aug2011, Vol. 82 Issue 8, p942 

    The article presents a case study of a 68-year-old male who requested neurological and magnetic resonance imaging (MRI) examinations following the death of his sister due to subarachnoid haemorrhage. The patient was having a difficulty using his right hand, the first symptom of Creutzfeld Jakob...

  • The EEG in E200K familial CJD: relation to MRI patterns. Appel, Shmuel; Chapman, Joab; Prohovnik, Isak; Hoffman, Chen; Cohen, Oren; Blatt, Ilan // Journal of Neurology;Mar2012, Vol. 259 Issue 3, p491 

    The aim of the study was to examine the relationship between EEG abnormalities and the pattern of MRI changes in familial Creutzfeldt-Jakob Disease (fCJD) patients with E200K mutation. As part of a controlled, prospective study, 13 E200K fCJD patients underwent comprehensive evaluations, with...

  • Molecular pathogenesis of prion diseases. Kretzschmar, Hans A. // European Archives of Psychiatry & Clinical Neuroscience;1999 Supplement 3, Vol. 249, pS56 

    Abstract Prion diseases such as Creutzfeldt-Jakob disease in humans, scrapie in sheep, and BSE in cattle are transmissible and fatal neurodegenerative diseases. The infectious agent of these diseases has been designated as "prion". It consists mainly and perhaps exclusively of a conformational...

  • Magnetic Resonance Spectroscopy and Measurement of Tau Epitopes of Autopsy Proven Sporadic Creutzfeldt-Jakob Disease in a Patient with Non-Specific Initial EEG, MRI and Negative 14-3-3 Immunoblot. Šarac, Helena; Hanjšek, Sanja; Bašić, Silvio; Henigsberg, Neven; Radoš, Marko; Šimić, Goran // Collegium Antropologicum;Jan2008 Supplement 1, Vol. 32, p199 

    Limited potential of electroencephalogram (EEG), magnetic resonance images (MRI) and cerebrospinal fluid (CSF) test for 14-3-3 protein in the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) resulted in developments in diagnostic premortem tehniques. Recent studies provided...

  • Extensive cortical damage in a case of Creutzfeldt-Jacob disease: clinicoradiological correlations. Bergui, M.; Bradac, G. B.; Rossi, G.; Orsi, L. // Neuroradiology;May2003, Vol. 45 Issue 5, p304 

    MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jacob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on...

  • Sporadic onset Creutzfeldt-Jacob disease: Interesting MRI observations. Praveen, K. S.; Sinha, S.; Chandrasekhar, H. S.; Vijayan, J.; Taly, A. B. // Neurology India;Dec2006, Vol. 54 Issue 4, p418 

    The article describes the magnetic resonance images (MRI) of a 60-year-old female patient presenting with sporadic Creutzfeldt-Jacob disease. Brain MRI revealed high signal intensity on T2 weighted image, with fluid inversion recovery sequences in the caudate and putamen bilaterally. A...

  • Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for creutzfeldt-jakob disease. McKnight, Alexia L.; Minkoff, Lawrence A.; Sutton, Diane L.; Thomsen, Bruce V.; Habecker, Perry L.; Sweeney, Raymond W.; Smith, Gary; Dasanu, Constantin A.; Ichim, Thomas E.; Alexandrescu, Doru T.; Stutman, Joel M. // Journal of Translational Medicine;2010, Vol. 8, p125 

    Background: Magnetic resonance imaging has been used in the diagnosis of human prion diseases such as sCJD and vCJD, but patients are scanned only when clinical signs appear, often at the late stage of disease. This study attempts to answer the questions "Could MRI detect prion diseases before...

  • Creutzfeldt-Jakob Disease Is A Rare Fatal Disease With No Treatment. Rasheed, M. U.; Mimano, Lucy N. // Internet Journal of Infectious Diseases;2007, Vol. 6 Issue 1, p3 

    Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder caused by prions. The patient is usually mute and immobile in the terminal stages and in most cases, death occurs within a few months of onset of symptoms. Electroencephalogram, Cerebrospinal fluid 14-3-3...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics