Reading the Tea Leaves: Anticarcinogenic Properties of (-)-Epigallocatechin-3-Gallate

Carlson, Jennifer R.; Bauer, Brent A.; Vincent, Ann; Limburg, Paul J.; Wilson, Ted
June 2007
Mayo Clinic Proceedings;Jun2007, Vol. 82 Issue 6, p725
Academic Journal
Green tea is an extremely popular beverage worldwide. Derivatives of green tea, particularly (-)-epigallocatechin-3-gallate (EGCG), have been proposed to have anticarcinogenic properties based on preclinical, observational, and clinical trial data. To summarize, clarify, and extend current knowledge, we conducted a comprehensive search of the PubMed database and other secondary data sources, as appropriate, regarding the chemopreventive potential of EGCG. Apparently, EGCG functions as an antioxidant, preventing oxidative damage in healthy cells, but also as an antianglogenic agent, preventing tumors from developing a blood supply needed to grow larger. Furthermore, EGCG may stimulate apoptosis in cancerous cells by negatively regulating the cell cycle to prevent continued division. Finally, EGCG exhibits antibacterial activity, which may be implicated in the prevention of gastric cancer. Although in vitro research of the anticarcinogenic properties of EGCG seems promising, many diverse and unknown factors may influence its in vivo activity in animal and human models. Some epidemiological studies suggest that green tea compounds could protect against cancer, but existing data are inconsistent, and limitations in study design hinder full interpretation and generalizability of the published observational findings. Several clinical trials with green tea derivatives are ongoing, and further research should help to clarify the clinical potential of EGCG for chemoprevention and/or chemotherapy applications.


Related Articles

  • Green tea constituents (−)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I— and topoisomerase II—DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. López-Lázaro, Miguel; Calderón-Montaño, José Manuel; Burgos-Morón, Estefanía; Austin, Caroline A. // Mutagenesis;Jul2011, Vol. 26 Issue 4, p489 

    Green tea and its major active constituent, (−)-epigallocatechin-3-gallate (EGCG), are in clinical trials for the prevention and treatment of several diseases such as cancer. DNA topoisomerase (topo) poisons are commonly prescribed anticancer drugs that kill cancer cells by inducing...

  • War on Cancer. Moss, Ralph // Townsend Letter;Jan2016, Issue 390, p83 

    The article discusses the discovery of cell surface protein called ENOX2 by professors D. James Morré and Dorothy Morré of Purdue University, Indiana. It states that ENOX2 is considered as anticancer agents with a combination of concentrated green tea and pure chili pepper. An overview on...

  • Green Tea Polyphenols as Proteasome Inhibitors: Implication in Chemo-prevention. Yang, H.; Landis-Piwowar, K.; Chan, T. H.; Dou, Q. P. // Current Cancer Drug Targets;Mar2011, Vol. 11 Issue 3, p296 

    No abstract available.

  • Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model. Ala Y. Issa; Suresh R. Volate; Stephanie J. Muga; Daniela Nitcheva; Theresa Smith; Michael J. Wargovich // Carcinogenesis;Sep2007, Vol. 28 Issue 9, p1978 

    One of the liabilities of the ApcMin mouse as a model for colon cancer is its lack of a robust tumor response in the large bowel. In our protocol, we treated the ApcMin mouse with azoxymethane, a colon-selective carcinogen. This protocol induced a 4-fold increase in the number of colon tumors....

  • Tumor invasion: molecular shears blunted by green tea. Garbisa, Spiridione; Biggin, Susan; Cavallarin, Nadia; Sartor, Luigi; Benelli, Roberto; Albini, Adriana // Nature Medicine;Nov99, Vol. 5 Issue 11, p1216 

    To the editor?The recent press, both popular and scientific, has given wide coverage of the beneficial properties of green tea, most commonly used in Asian countries. Consumption has been associated with prevention of cancer development and metastasis. The main flavonol of green tea,...

  • Green tea therapy. Stoddart, Alison // Nature Materials;Nov2014, Vol. 13 Issue 11, p998 

    The article focuses on a research concerning anticancer effect of nanocomplexes in which antitumour proteins are self-assembled with macromolecular derivatives of an ingredient of green tea, by Joo Eun Chung and colleagues published in 2014 issue of the journal "Nature Nanotechnology."

  • Betulinic acid-induced apoptosis in leukemia cells. Ehrhardt, H.; Fulda, S.; Führer, M.; Debatin, K. M.; Jeremias, I. // Leukemia (08876924);Aug2004, Vol. 18 Issue 8, p1406 

    Betulinic acid (BA), a natural component isolated from Birch trees, effectively induces apoptosis in neuroectodermal and epithelial tumor cells and exerts little toxicity in animal trials. Here, we show that BA-induced marked apoptosis in 65% of primary pediatric acute leukemia cells and all...

  • SU5416 and EGCG Work Synergistically and Inhibit Angiogenic and Survival Factors and Induce Cell Cycle Arrest to Promote Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-BE2 Cells. Mohan, Nishant; Karmakar, Surajit; Banik, Naren; Ray, Swapan // Neurochemical Research;Aug2011, Vol. 36 Issue 8, p1383 

    Malignant neuroblastomas are solid tumors in children. Available therapeutic agents are not highly effective for treatment of malignant neuroblastomas. Therefore, new treatment strategies are urgently needed. We tested the efficacy of combination of SU5416 (SU), an inhibitor of the vascular...

  • Mechanism of fenretinide (4-HPR)-induced cell death. Wu, J. M.; DiPietrantonio, A. M.; Hsieh, T.-C. // Apoptosis;Oct2001, Vol. 6 Issue 5, p377 

    4-HPR (fenretinide) is a synthetic analog of retinoic acid (RA) whose potential as a chemopreventative agent has gained support from in vitro and animal experiments and in limited clinical trials. Comparative analyses of cellular, biochemical, and molecular properties of fenretinide with RA...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics