Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin allergy

Pappalardo, F.; Franco, A.; G., G. Crescenzi; Poli, A.; Zangrillo, A.; Koster, A.
January 2007
Perfusion;Jan2007, Vol. 22 Issue 1, p67
Academic Journal
Heparin-induced IgE-mediated hypersensitivity and anaphylactoid reactions, although rare, can pose a serious clinical problem for patients requiring cardiopulmonary bypass (CPB). Bivalirudin is a bivalent reversible direct thrombin inhibitor, with a half-life of 25 min, eliminated mostly by proteolytic cleavage. There are some reports on the use of bivalirudin for cardiac surgery, particularly for heparin-induced thrombocytopenia (HIT), but none on cases of heparin allergy. We report a case of heparin allergy successfully managed for CPB with bivalirudin anticoagulation.


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