Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease

Hood, Ashley J.; Amador, Silvia C.; Cain, Ashley E.; Briand, Kevin A.; Al-Refai, Ali H.; Schiess, Mya C.; Sereno, Anne B.
June 2007
Journal of Neurology, Neurosurgery & Psychiatry;Jun2007, Vol. 78 Issue 6, p565
Academic Journal
Background: The integrity of frontal systems responsible for voluntary control and their interaction with subcortical regions involved in reflexive responses were studied in patients with Parkinson's disease (PD). Previous studies have shown that patients with PD have impaired executive function, including deficits in attention, motor planning and decision making. Methods: Executive function was measured through eye movements: reflexive (stimulus driven) prosaccades and voluntary (internally guided) antisaccades. Patients with advanced idiopathic PD, off and on their optimal levodopa therapy, were tested on a prosaccade and an antisaccade task and compared with matched controls. Results: Levodopa significantly increased response time for reflexive prosaccades and reduced error rate for voluntary antisaccades. Conclusions: Consistent with our proposed model, patients with PD in the medicated state are better able to plan and execute voluntary eye movements. These findings suggest levodopa improves function of the voluntary frontostriatal system, which is deficient in PD.


Related Articles

  • Vascular hemiparkinsonism sensitive to levodopa. Veran, O.; Calizzano, A.; Grand, S.; Krack, P. // Journal of Neurology, Neurosurgery & Psychiatry;Nov2008, Vol. 79 Issue 11, p1244 

    The article presents an overview of an acute-onset left oculomotor paresis and right hemiparesis of a 23-year-old woman. It presents the image which shows a small midbrain hematoma in the left substantia negra. It indicates a rapid improvement on the vascular hemiparkinsonism with levodopa and a...

  • The wide clinical spectrum and nigrostriatal dopaminergic damage in spinocerebellar ataxia type 6. Jong-Min Kim // Journal of Neurology, Neurosurgery & Psychiatry;May2010, Vol. 81 Issue 5, p529 

    Spinocerebellar ataxia type 6 (SCA6) manifests a wide spectrum of non-cerebellar system involvements. The objective of this study was to examine the presence of nigrostriatal dopaminergic system derangement in SCA6. Eight patients with SCA6 who underwent a regular follow-up for at least...

  • Treatment of Parkinson Disease: A 64-Year-Old Man With Motor Complications of Advanced Parkinson Disease. Tarsy, Daniel // JAMA: Journal of the American Medical Association;6/6/2012, Vol. 307 Issue 21, p2305 

    The article discuses the cases study of Parkinson disease in a 64-year-old man with a past history of stroke and focuses on the medical treatment of the disease. The man was diagnosed with Parkinson disease in 1999 with symptoms such as left-sided clumsiness, loss of dexterity, and depression...

  • The benefits of pramipexole selection in the treatment of Parkinson's disease. Silindir, Mine; Ozer, A. // Neurological Sciences;Oct2014, Vol. 35 Issue 10, p1505 

    Levodopa administration as a gold standard in Parkinson's disease (PD) treatment is very valuable, however, long-term administration may cause some motor complications such as abnormal unintended movements and shortening response to each dose (wearing off phenomenon). Dopamine agonists were...

  • Motor and nonmotor complications in Parkinson's disease: an argument for continuous drug delivery? Chaudhuri, K.; Rizos, Alexandra; Sethi, Kapil // Journal of Neural Transmission;Sep2013, Vol. 120 Issue 9, p1305 

    The complications of long-term levodopa therapy for Parkinson's disease (PD) include motor fluctuations, dyskinesias, and also nonmotor fluctuations-at least equally common, but less well appreciated-in autonomic, cognitive/psychiatric, and sensory symptoms. In seeking the pathophysiologic...

  • Commentary. Dhikav, Vikas // Journal of Neurosciences in Rural Practice;Jan-Mar2016, Vol. 7 Issue 1, p70 

    The author discusses the management of young-onset Parkinson's disease (YOPD) which must aim to maintain occupational, social and daily functioning while delaying motor complications of treatment, providing psychological support and preventing psychiatric complications including depression where...

  • Inhaled Levodopa Reduces Off Time in Parkinson's Disease. Greb, Erik // Neurology Reviews;Oct2016, Vol. 24 Issue 10, p45 

    The article reports that self-administration of an inhalable formulation of levodopa improves motor function and reduces off time in people with Parkinson's disease, according to data published in the September 2016 issue of the journal "Movement Disorders." Topics covered include irregular...

  • Parkinson's disease. Worth, Paul // Pulse;Oct2013, p60 

    The article offers tips for diagnosis and management of Parkinson's disease. The author suggests to become aware on unusual symptoms on motor activities. He mentions that symptoms should be clear before treatment to prevent false diagnosis. He states that patients diagnosed with Parkinson's...

  • Archives of Neurology: Persistent ocular tremors appear to be associated with Parkinson disease.  // Biomedical Market Newsletter;4/14/2012, Vol. 21, p1 

    The article informs that oculomotor testing can result in early diagnosis of Parkinson's disease.


Read the Article


Sign out of this library

Other Topics