Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms

Corley, Douglas A.; Kubo, Ai; Zhao, Wei
June 2007
Gut;Jun2007, Vol. 56 Issue 6, p756
Academic Journal
Objective: To evaluate the associations between abdominal obesity and gastro-oesophageal reflux disease (GORD), and their interactions with ethnicity and gender. Design: A cross-sectional study. Participants completed detailed symptom questionnaires and underwent a standardised examination, including anthropometric measurements. Setting: A large integrated healthcare system. Patients: 80 110 members of the Kaiser Permanente multiphasic health check-up cohort. Main outcome measures: Gastro-oesophageal reflux-type symptoms. Results: Recent reflux-type symptoms were present in 11% of the population. The multivariate OR for symptoms with an abdominal diameter (adjusted for body mass index (BMI)) of ⩾26 vs <16.3 cm was 1 .85 (95% CI 1 .55 to 2.21) for the white population, 0.95 (95% CI 0.61 to 1 .48) for the black population and 0.64 (95% CI 0.18 to 2.30) for Asians. The mean abdominal diameter was greater in men (22.0 cm, 95% CI 21.9 to 22.0) than in women (20.1 cm, 95% CI 20.0 to 20.1, p<0.01), but the risk of symptoms for any given diameter did not differ markedly by gender. The association between increasing BMI and symptoms was also much stronger among the white population than among the black population. The association between BMI and reflux-type symptoms was partially mediated through abdominal diameter. Conclusions: There was a consistent association between abdominal diameter (independent of BMI) and reflux-type symptoms in the white population, but no consistent associations in the black population or Asians. The BMI association was also strongest among the white population. These findings, combined with the increased prevalence of abdominal obesity in male subjects, suggest that an increased obesity may disproportionately increase GORD-type symptoms in the white population and in male subjects.


Related Articles

  • Body measures in relation to gastro-oesophageal reflux. Lagergren, Jesper // Gut;Jun2007, Vol. 56 Issue 6, p741 

    The author comments on a study about the association between overweight and gastro-esophageal reflux disease (GORD), published within the issue of the journal. The study evaluates body measures and body mass index (BMI) relation to GORD, and addresses the ethnic difference in the etiology of...

  • Obesity increases oesophageal acid exposure. El-Serag, Hashem B.; Ergun, Guichin A.; Pandolfino, John; Hizgerald, Stephanie; Iran, Thomas; Kramer, Jennifer R. // Gut;Jun2007, Vol. 56 Issue 6, p749 

    Background: Obesity has been associated with gastro-oesophageal reflux disease (GERD); however, the mechanism by which obesity may cause GERD is unclear. Aim: To examine the association between oesophageal acid exposure and total body or abdominal anthropometric measures. Methods: A...

  • Anthropometric indices and Gastro-Esophageal Reflux Disease in adult population in Tirana, Albania. Kraja, Bledar; Burazeri, Genc; Prifti, Skerdi // Medicinski Arhiv;2008, Vol. 62 Issue 3, p139 

    Purpose: To assess the association of Gastro-Esophageal Reflux Disease (GERD) with anthropometric indices [body mass index (BMI) and waist-to-hip ratio (W/H)] in the adult population of Tirana, the Albanian capital. Work method: A case-control study was conducted in Tirana in 2005-2007 including...

  • Is obesity associated with gastropharyngeal reflux disease? Cheol Woong Choi; Gwang Ha Kim; Chul Soo Song; Soo Geun Wang; Byung Joo Lee; I., Hoseok; Dae Hwan Kang; Geun Am Song // World Journal of Gastroenterology;1/14/2008, Vol. 14 Issue 2, p265 

    AIM: To examine the association between obesity and gastropharyngeal reflux disease (GPRD) as well as gastroesophageal reflux disease (GERD) METHODS: We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dualprobe pH monitoring from July 2003 to December 2006....

  • Correlation of Gastroesophageal Reflux Disease Symptoms with Body Mass Index. Zafar, Shamail; Haque, Israr U.; Tayyab, Ghias U. N.; Rehman, Ameed U.; Rehman, Adeel U.; Chaudhry, Nusrat U. // Saudi Journal of Gastroenterology;Apr-Jun2008, Vol. 14 Issue 2, p53 

    Background/Aim: To find a correlation between symptoms of gastroesophageal reflux disease (GERD) and body mass index (BMI). Materials and Methods: A total of 603 patients who presented at Ghurki Trust Teaching Hospital and Surgimed Hospital Lahore with symptoms of GERD, were included and...

  • Is There Any Association Between Overweight, Obesity and Symptoms of Reflux Disease? Ebrahimi-Mameghani, Mehrangiz; Saghafi-Asl, Maryam; Arefhosseini, Seyedrafie; Khoshbaten, Manochehr // Pakistan Journal of Biological Sciences;2008, Vol. 11 Issue 3, p443 

    The present study was aimed to identify the association of overweight and obesity with gastroesophageal reflux disease (GERD). This age- and sex-matched case-control study was carried out in a sample of subjects referred to the specialized clinic of Tabriz University of Medical Sciences from...

  • Gastroesophageal Reflux Disease and Obesity: Not as Simple as We May Think. Richter, Joel // Digestive Diseases & Sciences;Jul2012, Vol. 57 Issue 7, p1748 

    No abstract available.

  • Laparoscopic Hiatus Hernia Repair and Simultaneous Sleeve Gastrectomy: A Novel Approach in the Treatment of Gastroesophageal Reflux Disease Associated with Morbid Obesity. Korwar, Vijay; Peters, Michael; Adjepong, Sam; Sigurdsson, Audun // Journal of Laparoendoscopic & Advanced Surgical Techniques;Dec2009, Vol. 19 Issue 6, p761 

    Obesity is associated with significantly increased risk of gastroesophageal reflux disease and recurrence of reflux symptoms following surgical intervention, compared to individuals with normal body-mass index (BMI). The severity of reflux symptoms and obesity is associated with a decreased...

  • The effect of obesity on the outcome of laparoscopic antireflux surgery. Chisholm, Jacob A.; Jamieson, Glyn G.; Lally, Carolyn J.; Devitt, Peter G.; Game, Philip A.; Watson, David I. // Journal of Gastrointestinal Surgery;Jun2009, Vol. 13 Issue 6, p1064 

    Background: Obesity has long been considered to be a predisposing factor for gastroesophageal reflux. It is also thought to predispose patients to a poorer clinical outcome following antireflux surgery. This study examined the effect of body mass index (BMI) on clinical outcomes...


Read the Article


Sign out of this library

Other Topics