TITLE

The Effect of Age on Response to Therapy With Peginterferon α Plus Ribavirin in a Cohort of Patients With Chronic HCV Hepatitis Including Subjects Older Than 65 Yr

AUTHOR(S)
Antonucci, Giorgio; Longo, Maria Antonella; Angeletti, Claudio; Vairo, Francesco; Oliva, Alessandra; Comandini, Ubaldo Visco; Tocci, Guido; Boumis, Evangelo; Noto, Pasquale; Solmone, Maria Carmela; Capobianchi, Maria R.; Girardi, Enrico
PUB. DATE
July 2007
SOURCE
American Journal of Gastroenterology;Jul2007, Vol. 102 Issue 7, p1383
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: In many industrialized countries HCV infection is characterized by an increasing prevalence during ageing; however, data on the efficacy of treatment among older patients are scarce. This study was set up to evaluate the effect of age on the treatment of chronic HCV hepatitis with peginterferon α plus ribavirin. METHODS: We retrospectively reviewed medical records of 153 adult patients with chronic HCV hepatitis treated with combination therapy; 30 of them (19.6%) were 65 years of age or older. RESULTS: In multivariable analysis, age groups ≥40 years had similar odds of achieving sustained virologic response ( P= 0.71) and significantly lower odds of sustained response compared with younger patients (odds ratio [OR] 0.16, 95% confidence interval [CI] 0.05–0.59, P= 0.006; OR 0.13, 95% CI 0.03–0.49, P= 0.002; OR 0.21, 95% CI 0.05–0.91, P= 0.037 for patients aged 40–49 years, 50–64 years, and older than 64 years, respectively). The effect of age was present in the 74 patients infected with genotype 1 or 4 ( P= 0.04), while among the 79 patients with genotype 2 or 3 sustained virologic response rates were relatively uniform, with no statistically significant differences. CONCLUSIONS: The probability of good response to combination treatment with peginterferon α plus ribavirin is decreased for patients aged more than 40 years infected with genotype 1 or 4, but patients aged more than 65 had a similar rate of response to those aged 40–64 years. Combination treatment may be safely extended to elderly patients with no major contraindications.
ACCESSION #
25489329

 

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