Clustering of Inflammatory Bowel Disease With Immune Mediated Diseases Among Members of a Northern California-Managed Care Organization

Xiaoping Weng; Liu, Liyan; Barcellos, Lisa F.; Allison, James E.; Herrinton, Lisa J.
July 2007
American Journal of Gastroenterology;Jul2007, Vol. 102 Issue 7, p1429
Academic Journal
BACKGROUND AND AIMS: Previous studies provide evidence that some immune-mediated diseases occur at greater frequency among inflammatory bowel disease (IBD) patients than in the general population. The present study examined the co-occurrence of IBD with common immune-mediated disorders including asthma, psoriasis, type 1 diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, vitiligo, autoimmune thyroiditis (Grave's and Hashimoto's), and chronic glomerulonephritis. METHODS: We conducted a cross-sectional study among members of the Kaiser Permanente Medical Care Program for the period 1996–2005. A total of 12,601 patients with at least two IBD diagnoses in computerized visit data were ascertained. Four persons without IBD were matched to each IBD patient on age, gender, and length of enrollment. Information on co-occurring diseases was obtained from computerized visit data for 1996–2005. Conditional logistic regression was used to estimate the odds ratio and 95% confidence interval for the association of IBD with immune-mediated disorders after adjusting for smoking. RESULTS: Seventeen percent of the IBD patients and 10% of the persons without IBD had a diagnosis for at least one immune-mediated disease. IBD patients were more likely to have asthma (1.5, 95% CI 1.4–1.6), psoriasis (1.7, 95% CI 1.5–2.0), rheumatoid arthritis (1.9, 95% CI 1.5–2.3), and multiple sclerosis (2.3, 95% CI 1.6–3.3). CONCLUSIONS: Among the immune-mediated diseases we studied, most were more common in IBD patients than in persons without IBD, suggesting that IBD shares common etiologic factors with other immune-mediated diseases.


Related Articles

  • Early life environment and natural history of inflammatory bowel diseases. Guo, Abra Y.; Stevens, Betsy W.; Wilson, Robin G.; Russell, Caitlin N.; Cohen, Melissa A.; Sturgeon, Holly C.; Thornton, Anna; Giallourakis, Cosmas; Khalili, Hamed; Nguyen, Deanna D.; Sauk, Jenny; Yajnik, Vijay; Xavier, Ramnik J.; Ananthakrishnan, Ashwin N. // BMC Gastroenterology;2014, Vol. 14 Issue 1, p221 

    Background: Early life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn's disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has not been previously examined. Methods: This single center study included...

  • Measures of relative importance for health-related quality of life. Sajobi, Tolulope; Lix, Lisa; Clara, Ian; Walker, John; Graff, Lesley; Rawsthorne, Patricia; Miller, Norine; Rogala, Linda; Carr, Rachel; Bernstein, Charles // Quality of Life Research;Feb2012, Vol. 21 Issue 1, p1 

    Purpose: In health-related quality of life (HRQOL) studies, data are often collected on multiple domains for two or more groups of study participants. Quantitative measures of relative importance, which are used to rank order the domains based on their ability to discriminate between groups, are...

  • The Relationship Among Perceived Stress, Symptoms, and Inflammation in Persons With Inflammatory Bowel Disease. Targownik, Laura E; Sexton, Kathryn A; Bernstein, Matthew T; Beatie, Brooke; Sargent, Michael; Walker, John R; Graff, Lesley A // American Journal of Gastroenterology;Jul2015, Vol. 110 Issue 7, p1001 

    OBJECTIVES:Previous studies have demonstrated that stress is associated with increased disease activity in individuals with inflammatory bowel disease (IBD). The association between perceived stress and gastrointestinal inflammation is not well described.METHODS:Participants were recruited from...

  • IBD audits show better care with room for improvement.  // Gastrointestinal Nursing;Mar2012, Vol. 10 Issue 2, p11 

    The article reports on two national audits on inflammatory bowel disease (IBD) care for adults and children. The UK IBD Audit, which examined care for adults, shows that the percentage of patients seen by an IBD nurse specialist has doubled, while the admission rates for patients with ulcerative...

  • Environmental Risk Factors for Inflammatory Bowel Diseases: A Review. Ananthakrishnan, Ashwin // Digestive Diseases & Sciences;Feb2015, Vol. 60 Issue 2, p290 

    Inflammatory bowel diseases comprising Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically mediated diseases. The key mechanism underlying the pathogenesis of these diseases is a dysregulated immune response to commensal flora in a genetically susceptible host. Thus...

  • A population-based study examining the risk of malignancy in patients diagnosed with inflammatory bowel disease. Wilson, J.; Furlano, Raoul; Jick, Susan; Meier, Christoph; Wilson, J Claire; Furlano, Raoul I; Jick, Susan S; Meier, Christoph R // Journal of Gastroenterology;Nov2016, Vol. 51 Issue 11, p1050 

    Background: Recent studies suggest an increased risk of malignancy in patients with inflammatory bowel disease (IBD), although the findings were inconsistent. We used data from the clinical practice research datalink (CPRD) to further examine this association.Methods:...

  • Predictors of Steroid Treatment Failure and Validation of Previous Models for Severe Attacks of Ulcerative Colitis. Jung-Wook Kim; Hyo Jong Kim; Chang Kyun Lee; Hyuck Kim; A. Ri Shin; Kyung Hwan Kang; Min Kyoung Kim; Hyun Jin Park; Hoe Hoon Chung; Eun Jung Hwang // Intestinal Research;2012, Vol. 10 Issue 3, p251 

    Background/Aims: Some clinical and laboratory parameter are predictors to determine steroid treatment failure in patients acute severe ulcerative colitis. We aimed to validate previous models in the Korean patients. Methods: This study was conducted retrospectively with 70 patients who were...

  • Contribution of IBD5 Locus to Clinical Features of IBD Patients. Latiano, Anna; Palmieri, O.; Valvano, Rossella M.; D’Incà, Renata; Vecchi, Maurizio; Ferraris, Angelo; Sturniolo, Giacomo C.; Spina, Luisa; Lombardi, Giovanni; Dallapiccola, Bruno; Andriulli, Angelo; Devoto, Marcella; Annese, Vito // American Journal of Gastroenterology;Feb2006, Vol. 101 Issue 2, p318 

    AIM: The aim of this study was to investigate the influence of the IBD5 locus on clinical features of inflammatory bowel disease (IBD) patients, and its possible interaction with the CARD15 gene. PATIENTS AND METHODS: A cohort of 1,199 IBD patients (570 with CD and 629 with ulcerative colitis...

  • Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study. Høivik, Marte Lie; Moum, Bjørn; Solberg, Inger Camilla; Henriksen, Magne; Cvancarova, Milada; Bernklev, Tomm // Gut;Mar2013, Vol. 62 Issue 3, p368 

    Objective To compare the work disability (WD) rate in inflammatory bowel disease (IBD) patients 10 years after disease onset, with the WD rate in the background population, and to assess whether clinical or demographic factors in the early disease course could predict WD after 10 years disease....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics