TITLE

Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation

AUTHOR(S)
Yates, B.; Murphy, D. M.; Fisher51, A. J.; Gould, F. K.; Lordan, J. L.; Dark, J. H.; Corns, P. A.; Fisher, A J; Corris, P A
PUB. DATE
June 2007
SOURCE
Thorax;Jun2007, Vol. 62 Issue 6, p554
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Pseudomembranous colitis is an uncommon complication in patients with cystic fibrosis, despite the use of multiple high-dose antibiotic regimens and the frequency of hospital admissions. Four patients from a total of 137 patients with cystic fibrosis undergoing lung transplantation are described who developed fulminant pseudomembranous colitis. Initial presentation was variable and the mortality rate was 50% despite urgent colectomy. In one case the presenting abdominal distension was thought to be due to meconium ileus equivalent. It is concluded that Clostridium difficile colitis may be a difficult diagnosis in patients with cystic fibrosis and follows a fulminant course after lung transplantation.
ACCESSION #
25471948

 

Related Articles

  • Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis. de Boer, Kaïssa; Vandemheen, Katherine L.; Tullis, Elizabeth; Doucette, Steve; Fergusson, Dean; Freitag, Andreas; Paterson, Nigel; Jackson, Mary; Lougheed, M. Diane; Kumar, Vijay; Aaron, Shawn D. // Thorax;Aug2011, Vol. 66 Issue 8, p680 

    Background Despite advances in treatment of cystic fibrosis (CF), pulmonary exacerbations remain common. The aim of this study was to determine if frequent pulmonary exacerbations are associated with greater declines in lung function, or an accelerated time to death or lung transplantation in...

  • Management of cystic fibrosis before and after lung transplantation. Egan, J. J.; Woodcock, A. A.; Webb, A. K. // Journal of the Royal Society of Medicine (Supplement);Feb1997, Vol. 90 Issue 31, p47 

    The article provides information on the management of cystic fibrosis before and after lung transplantation. Prior to transplantation, preservation of pulmonary function with aggressive antibiotic therapy to control pulmonary sepsis is essential. After transplantation, cystic fibrosis patients...

  • Lung transplantation for cystic fibrosis: a single center experience of 100 consecutive cases†. Inci, Ilhan; Stanimirov, Olivia; Benden, Christian; Kestenholz, Peter; Hofer, Markus; Boehler, Annette; Weder, Walter // European Journal of Cardio-Thoracic Surgery;Feb2012, Vol. 41 Issue 2, p435 

    OBJECTIVE Lung transplantation is the ultimate treatment option for patients with end-stage cystic fibrosis (CF) lung disease. Despite poorer reports on survival benefit for CF patients undergoing lung transplantation, several centers, including ours were able to show a survival benefit. This...

  • Urgent lung transplantation in cystic fibrosis patients: experience of a French center. Saueressig, Maurício Guidi; Pelluau, Sonia; Sermet, Isabelle; Souilamas, Redha // European Journal of Cardio-Thoracic Surgery;Sep2011, Vol. 40 Issue 3, pe101 

    Abstract: Objective: We report preliminary results obtained with urgent lung transplantation (ULTx) in cystic fibrosis (CF) patients, based on a French high emergency lung allocation (HELA) system, and the impact of this system on waiting-list death. Methods: The medical records of the first 15...

  • Factors associated with early graft dysfunction in cystic fibrosis patients receiving primary bilateral lung transplantation. Felten, Marie-Louise; Sinaceur, Mériem; Treilhaud, Michèle; Roze, Hadrien; Mornex, Jean-François; Pottecher, Julien; Journois, Didier; Fischler, Marc // European Journal of Cardio-Thoracic Surgery;Mar2012, Vol. 41 Issue 3, p686 

    OBJECTIVES Primary graft dysfunction (PGD) occurs in 10–25% of cases and remains responsible for significant morbidity and mortality after lung transplantation. Our goal was to explore donor and recipient variables and procedure factors that could be related to early graft failure in...

  • Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients. Belle-van Meerkerk, Gerdien; de Jong, Pim A.; de Valk, Harold W.; Neefjes, Tim; Pameijer, Frank A.; Kwakkel-van Erp, Johanna M.; van de Graaf, Ed A. // PLoS ONE;12/23/2015, Vol. 10 Issue 12, p1 

    Objectives: Peri- and postoperative complications diminish the outcome of lung transplantation (LTx) in patients with cystic fibrosis (CF). We hypothesized that the degree of pathological findings on pre-LTx high resolution computed tomography (HRCT) is associated with higher morbidity and...

  • Lung Transplantation for Children With CF May Do More Harm Than Good.  // Pulmonary Reviews;Jan2008, Vol. 13 Issue 1, p1 

    The article discusses the findings of a research from the University of Utah which concludes that lung transplantation for children with cystic fibrosis (CF) may increase risk of mortality. Survival is dependent on the child's age at transplantation, incidence of Staphylococcus aureus and...

  • Pancrelipase.  // Reactions Weekly;5/7/2005, Issue 1050, p15 

    Presents a case report involving a man who developed colonic ulcers during treatment with pancrelipase for cystic fibrosis. Findings of colonoscopy; Results of histological examination.

  • Paediatric respiratory mortality: past triumphs, future challenges. Russell, G. // Thorax;Dec2005, Vol. 60 Issue 12, p985 

    The article presents information related to paediatric respiratory mortality. The improving mortality from pneumonia reflects many medical advances other than new antibiotics. However, pneumonia is not the only important cause of respiratory mortality in children. Although fewer than 5% of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics