Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation

Yates, B.; Murphy, D. M.; Fisher51, A. J.; Gould, F. K.; Lordan, J. L.; Dark, J. H.; Corns, P. A.; Fisher, A J; Corris, P A
June 2007
Thorax;Jun2007, Vol. 62 Issue 6, p554
Academic Journal
journal article
Pseudomembranous colitis is an uncommon complication in patients with cystic fibrosis, despite the use of multiple high-dose antibiotic regimens and the frequency of hospital admissions. Four patients from a total of 137 patients with cystic fibrosis undergoing lung transplantation are described who developed fulminant pseudomembranous colitis. Initial presentation was variable and the mortality rate was 50% despite urgent colectomy. In one case the presenting abdominal distension was thought to be due to meconium ileus equivalent. It is concluded that Clostridium difficile colitis may be a difficult diagnosis in patients with cystic fibrosis and follows a fulminant course after lung transplantation.


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