TITLE

Survey of acute renal failure in patients with cystic fibrosis in the UK

AUTHOR(S)
Bertenshaw, Carol; Watson, Alan R.; Lewis, Sarah; Smyth, Alan
PUB. DATE
June 2007
SOURCE
Thorax;Jun2007, Vol. 62 Issue 6, p541
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: There has been a recent increase in the number of reported cases of acute renal failure (ARF) in cystic fibrosis (CF). A study was undertaken to determine the incidence risk of ARF in patients with CF in the UK and to identify possible aetiological factors. Methods: All doctors working at UK CF centres were asked if they had been involved with the management of a patient with CF who had developed ARF. Those responding positively were asked to request informed consent for entry into the study and the patient's case notes were then reviewed. The analysis was restricted to patients developing ARF between 1997 and 2004. A second questionnaire sought information on aminoglycoside prescribing practice. Results: Responses were received from 55 of 56 centres with 64 reports, 9 of which were duplicates, leaving 55 cases. Consent was obtained for data extraction in 26 cases, of which 24 fitted the criteria for ARF (verified data). Median age at presentation with ARF was 9.7 years (range 0.4-31.8) and 12 cases were male. The incidence risk of ARF was 4.6 (verified data) to 10.5 cases (all data)/10,000 CF patients/year. In 21 cases (88%) an aminoglycoside was prescribed at onset of ARF or in the preceding week; 16 (76%) of those receiving an aminoglycoside had gentamicin. A renal biopsy was performed in 7 cases and histological examination revealed acute tubular necrosis in 6, all of whom had received gentamicin. Renal dialysis was required in 13 cases (54%). Complete recovery was seen in 22/24 patients (92%). Conclusions: ARF is increasingly being recognised in patients with CF. There is significant morbidity with most patients requiring dialysis. This study implicates intravenous aminoglycosides, particularly gentamicin, in the aetiology of ARF in CF.
ACCESSION #
25471946

 

Related Articles

  • Is it necessary to distinguish between alcoholic and nonalcoholic chronic pancreatitis? Mayerle, Julia; Lerch, Markus M. // Journal of Gastroenterology;Jan2007 Supplement 17, Vol. 42, p127 

    The article discusses the study on the necessity of distinguishing alcoholic and nonalcoholic chronic pancreatitis. According to the study, it is essential to determine the etiology of chronic pancreatitis because types of pancreatitis that are treatable need to be distinguished from...

  • Cystic fibrosis in adults.  // British Medical Journal;9/15/1979, Vol. 2 Issue 6191, p626 

    Focuses on the etiology of cystic fibrosis in adults. Determination of the widespread dysfunction of exocrine glands; Prevalence of the disease among blacks and mongoloid people; Manifestations of cystic fibrosis and the response of patients to medical measures.

  • FSGS: The Most Common Cause of Unexplained Nephrotic Syndrome in Balck Adults.  // Kidney;May/Jun98, Vol. 7 Issue 3, p106 

    Discusses the abstract of the research paper entitled 'Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976-1979 and 1995-1997,' by M. Haas, S.M. Meehan et al and published in a 1997 issue of the 'American Journal of Kidney Diseases.'

  • The progression of renal disease. Klahr, S.; Schreiner, G. // New England Journal of Medicine;6/23/88, Vol. 318 Issue 25, p1657 

    Discusses the causes of renal disease; Findings that no single aberration in glomerular physiology is responsible; Description of the several potential risk factors that may contribute to the progression of renal disease; Danger of interventions in slowing or halting kidney function;...

  • Gitelman's syndrome revisited: An evaluation of symptoms and health-related quality of life. Cruz, Dinna N.; Shaer, Andrea J.; Bia, Margaret J.; Lifton, Richard P.; Simon, David B. // Kidney International;Feb2001, Vol. 59 Issue 2, p710 

    Focuses on the etiological analysis of Gitelman's syndrome. Cytological effects of thiazide-sensitive sodium chloride cotransporter gene on the occurrence of the disease; Symptoms of the renal disorder; Assessment of the quality of life of GS patients.

  • Polycystic disease of the kidneys.  // British Medical Journal;2/3/1979, Vol. 1 Issue 6159, p291 

    Focuses on the nature and etiology of polycystic disease of the kidneys. Types of the disease; Signs and symptoms of the disease; Treatment of the disease.

  • Chronic kidney disease.  // Nursing Standard;11/15/2006, Vol. 21 Issue 10, p58 

    A quiz concerning the causes of chronic kidney disease and its treatment is presented.

  • The European Cystic Fibrosis Society Patient Registry: valuable lessons learned on how to sustain a disease registry. Vivian, Laura; Zolin, Anna; Mehta, Anil; Olesen, Hanne Vebert // Orphanet Journal of Rare Diseases;2014, Vol. 9 Issue 1, p1 

    Background Disease registries have the invaluable potential to provide an insight into the natural history of the disease under investigation, to provide useful information (e.g. through health indicators) for planning health care services and to identify suitable groups of patients for clinical...

  • IX. From Clinical Judgment to Clinical Trial. Talavera, Juan O.; Rivas-Ruiz, Rodolfo // Revista Medica del IMSS;2013 supplement, Vol. 51, pS58 

    Two strategies are described, intended to understand causality and documenting it with the best evidence: the clinical judgment and clinical trial. In the first one, the baseline state, the maneuver and the outcome are identified, each one with characteristics showing the complexity of the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics