Systemic inflammation and decline in lung function in a general population: a prospective study

Fogarty, Andrew W.; Jones, Stuart; Britton, John R.; Lewis, Sarah A.; McKeever, Tricia M.
June 2007
Thorax;Jun2007, Vol. 62 Issue 6, p515
Academic Journal
journal article
Background: An increase in levels of C-reactive protein (CRP), a marker of systemic inflammation, is associated with reduced forced expiratory volume in 1 s (FEV1), supporting the hypothesis that the pathophysiology of chronic obstructive pulmonary disease has a systemic inflammatory component. However, few large studies have assessed the relationship between systemic inflammation as measured by CRP and decline in lung function prospectively in a randomly selected population.Methods: In 1991, data were collected on FEV1 and forced vital capacity (FVC) and a blood sample was taken from 2442 randomly selected adults in a community-based cohort. In 2000 these measures were repeated in 1301 individuals. The level of serum CRP was analysed in these samples from 1991 and 2000.Results: In cross-sectional analyses of data from 1991 and 2000, serum CRP levels were inversely related to FEV1 and FVC. After adjustment for smoking and other confounders, the difference in FEV1 was reduced by -9 ml (95% CI -13 to -5) and -7 ml (95% CI -13 to -2) for each mg/l increment in serum CRP in 1991 and 2000, respectively. There was no significant association between baseline serum CRP levels and decline in FEV1 and FVC over 9 years.Conclusions: Although serum CRP levels are inversely associated with lung function in cross-sectional studies, there was no effect of a marker of systemic inflammation on decline in lung function over 9 years.


Related Articles

  • Systemic Inflammation in Young Adults Is Associated with Abnormal Lung Function in Middle Age. Kalhan, Ravi; Tran, Betty T.; Colangelo, Laura A.; Rosenberg, Sharon R.; Liu, Kiang; Thyagarajan, Bharat; Jacobs Jr, David R.; Smith, Lewis J. // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: Systemic inflammation is associated with reduced lung function in both healthy individuals and those with chronic obstructive pulmonary disease (COPD). Whether systemic inflammation in healthy young adults is associated with future impairment in lung health is uncertain....

  • MDCT assessment of airway wall thickness in COPD patients using a new method: correlations with pulmonary function tests. Achenbach, Tobias; Weinheimer, Oliver; Biedermann, Alexander; Schmitt, Sabine; Freudenstein, Daniela; Goutham, Edula; Kunz, Richard; Buhl, Roland; Dueber, Christoph; Heussel, Claus // European Radiology;Dec2008, Vol. 18 Issue 12, p2731 

    Quantitative assessment of airway-wall dimensions by computed tomography (CT) has proven to be a marker of airway-wall remodelling in chronic obstructive pulmonary disease (COPD) patients. The objective was to correlate the wall thickness of large and small airways with functional parameters of...

  • Current climate for COPD.  // Update;12/15/2005, Vol. 71 Issue 6, p22 

    This article presents information on chronic obstructive pulmonary disease (COPD). Until the past few years, its diagnosis was difficult to make, as most GP practices did not have access to spirometry. For the first time, GPs are encouraged and rewarded for providing high-quality COPD diagnoses...

  • A new experimental model of cigarette smoke-induced emphysema in Wistar rats. de las Heras Kozma, Rodrigo; Marcelino Alves, Edson; Barbosa-de-Oliveira, Valter Abraão; Tenorio Quirino dos Santos Lopes, Fernanda Degobbi; Cenize Guardia, Renan; Vivi Buzo, Henrique; Arruda de Faria, Carolina; Yamashita, Camila; Cavazzana Júnior, Manzelio; Frei, Fernando; de Oliveira Ribeiro-Paes, Maria José; Tadeu Ribeiro-Paes, João // Jornal Brasileiro de Pneumologia;ene/feb 2014, Vol. 40 Issue 1, p46 

    Objective: To describe a new murine model of cigarette smoke-induced emphysema. Methods: Twenty-four male Wistar rats were divided into two groups: the cigarette smoke group, comprising 12 rats exposed to smoke from 12 commercial filter cigarettes three times a day (a total of 36 cigarettes per...

  • Elevated cardiovascular risk among adults with obstructive and restrictive airway functioning in the United States: a cross-sectional study of the National Health and Nutrition Examination Survey from 2007-2010. Ford, Earl S.; Wheaton, Anne G.; Mannino, David M.; Li, Chaoyang; Croft, Janet B. // Respiratory Research;Dec2012, Vol. 13 Issue 12, p1 

    Background: Reasons for the excess risk for cardiovascular disease among people with chronic obstructive pulmonary disease remain unclear. Our objective was to examine the cardiovascular risk profile for adults with obstructive and restrictive impairments of lung functioning in a representative...

  • Combat COPD.  // Prevention India;Apr2012, p6 

    The article offers information related to chronic obstructive pulmonary disorder (COPD), a condition which progressively impairs lung functions. The disease can be diagnosed with lung function assessment with spirometry, physical examination and a chest X-ray. According to research, smokers tend...

  • Drugs 'can slow COPD'. Pedder, Cato // Pulse;5/24/2007, Vol. 67 Issue 20, p8 

    The article focuses on the significance of drug treatment in reducing the progression of Chronic obstructive pulmonary disease (COPD). It was found out that patients on a combination of sameterol and fluticasone propionate slower rate of decline of lung function than those on medication. This...

  • Effects of Physical activity on exercise tests and respiratory function. Cheng, Y. J.; Macera, C. A.; Addy, C. L.; Sy, F. S.; Wieland, D.; Blair, S. N. // British Journal of Sports Medicine;Dec2003, Vol. 37 Issue 6, p521 

    Background: Exercise is an important component of pulmonary rehabilitation for patients with chronic lung disease. Objective: To explore the role of physical activity in maintaining cardiac and respiratory function in healthy people. Methods: Cardiorespiratory fitness was measured by a maximal...

  • Patterns of pulmonary dysfunction in asbestos workers: a cross-sectional study. Abejie, Belayneh A.; Xiaorong Wang; Kales, Stefanos N.; Christiani, David C. // Journal of Occupational Medicine & Toxicology;2010, Vol. 5, p12 

    Background: Restrictive patterns of pulmonary function abnormalities associated with asbestos exposure are well described. Studies are less consistent, however, regarding the association of asbestos inhalation with airway dysfunction and obstructive impairment. Methods: We compared pulmonary...


Read the Article


Sign out of this library

Other Topics