Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity

Ryan, Silke; Nolan, Geraldine M.; Hannigan, Evelyn; Cunningham, Sean; Taylor, Cormac; McNicholas, Walter T.
June 2007
Thorax;Jun2007, Vol. 62 Issue 6, p509
Academic Journal
Background: High C-reactive protein (CRP) and homocysteine levels are risk factors for cardiovascular disease. Some, but not all, previous studies have reported increased levels of CRP and homocysteine in patients with obstructive sleep apnoea syndrome (OSAS). A study was undertaken to investigate the levels of these factors in carefully selected patients with OSAS and matched normal controls. Methods: CRP and homocysteine levels were measured in 110 subjects following polysomnography (PSG). Non-OSAS patients (group 1) were compared with two patient groups (mild/moderate OSAS (group 2) and severe OSAS (group 3)) group-matched for body mass index (BMI), and a fourth group of patients with severe OSAS who were more obese (group 4). All were free of other disease and similar in age, smoking habits and cholesterol levels. 50 suitable patients were commenced on continuous positive airway pressure (CPAP) treatment after PSG and 49 were reassessed 6 weeks later. Results: CRP levels were similar in groups 1, 2 and 3 (median (interquartile range (IQR)) 1.11 (0.76-2.11) mg/I vs 1.82 (1.20-3.71) mg/I vs 2.20 (1.16-3.59) mg/I; p = 0.727, Kruskal-WaIIis test), but were significantly higher in group 4 than in the other groups (5.36 (2.42-9.17) mg/I, p<0.05 by individual group comparisons). In multivariate analysis of all subjects, BMI was an independent predictor for CRP levels (β=0.221; p=0.006) but apnoea-hypopnoea index and other measures of OSAS were not. There was no difference in homocysteine levels between all four groups (p = 0.1). CPAP did not alter CRP (2.29 (1 .32-4.10) vs 2.84 (1 .13-5.40) mg/I; p = 0.145) or homocysteine levels (8.49 (3.66) vs 9.90 (4.72) µmol/I; p = 0.381). Conclusion: CRP and homocysteine levels are not associated with OSAS severity in men but CRP is independently associated with obesity.


Related Articles

  • Obstructive Sleep Apnea: Diagnosis, Epidemiology, and Economics. Kapur, Vishesh K. // Respiratory Care;Sep2010, Vol. 55 Issue 9, p1155 

    Obstructive sleep apnea (OSA) is a disorder characterized by intermittent upper-airway collapse, which impairs ventilation and disrupts sleep. Factors that contribute to upper-airway collapse include reduced upper-airway dilator muscle activity during sleep, specific upper-airway anatomical...

  • Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study. Gileles-Hillel, Alex; Alonso-Álvarez, María Luz; Kheirandish-Gozal, Leila; Peris, Eduard; Cordero-Guevara, José Aurelio; Terán-Santos, Joaquin; Martinez, Mónica Gonzalez; Jurado-Luque, María José; Corral-Peñafiel, Jaime; Duran-Cantolla, Joaquin; Gozal, David // Mediators of Inflammation;2014, Vol. 2014, p1 

    Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese...

  • Hypertension in Obstructive Sleep Apnoea. Del Colle, Sara; Carra, Renata; Rabbia, Franco; Papotti, Grazia; Verhovez, Andrea; Mulatero, Paolo; Veglio, Franco // Vascular Disease Prevention;Jan2005, Vol. 2 Issue 1, p29 

    Obstructive sleep apnoea syndrome (OSAS) is a clinical disorder associated with hypertension; recent guidelines suggest that it should be considered as one of the causes of refractory hypertension. Good clinical practice indicates that a patient with suspected sleep apnoea should undergo 24 h...

  • Sleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis. Tang, Sydney C. W.; Bing Lam; Tzy Jyun Yao; Wah Shing Leung; Chung Ming Chu; Yiu Wing Ho; Mary S. M. Ip; Kar Neng Lai // Kidney International;Jun2010, Vol. 77 Issue 11, p1031 

    Sleep apnea syndrome is increasingly recognized in peritoneal dialysis patients; however, its prognostic implication in this population is unknown. To study this, we prospectively followed the clinical outcome of 93 peritoneal dialysis patients with baseline polysomnography. Of these, 51 were...

  • Sleep apnea in adults: How accurate is clinical prediction? Jacobs, Christine K.; Coffey, John // Journal of Family Practice;Jun2009, Vol. 58 Issue 6, p327 

    The article reports on a study that evaluates the accuracy of clinical prediction for sleep apnea in adults. The Institute for Clinical Systems Improvement recommends polysomnography for patients with symptoms of obstructive sleep apnea hypopnea syndrome (OSAHS), cardiovascular disease,...

  • Losing Sleep Over Weight. Williams, James S.; Tacon, Anna; Carter, Rick // RT: The Journal for Respiratory Care Practitioners;May2008, Vol. 21 Issue 5, p20 

    The article discusses the links between sleep and obesity. The author draws a link between obesity and obstructive sleep apnea (OSA), the most common form of sleep apnea. Symptoms of sleep apnea are discussed, as are treatment plans. The article notes that consequences of leaving OSA...

  • SNORING AND OBSTRUCTIVE SLEEP APNOEA.  // Pulse;10/10/2007, Vol. 67 Issue 36, p51 

    The article discusses the dangers of obstructive sleep apnoea (OSA), and what works for snorers in Great Britain. OSA occurs when there is recurrent and frequent complete obstruction of the pharyngeal airway. It stated that long-term health consequences include cardiovascular complications such...

  • Obstructive sleep apnoea should be deemed a cardiovascular disease. Fuchs, Flávio Danni; Martinez, Denis // Heart;Aug2015, Vol. 101 Issue 16, p1261 

    The author focuses on the disregard for obstructive sleep disorder (OSA) as a risk factor for cardiovascular diseases by cardiologists. Topics discussed include OSA causing several cardiovascular disorders such as heart failure, diagnosis of OSA using polysomnography, treatment of OSA through...

  • Obstruktif Uyku Apne Sendromlu (OSAS) Olgularda Obezite Sıklığı ve Ek Hastalıklar. Ayık, Sibel ktem; Akhan, Galip; Peker, Şule // Turk Toraks Dergisi / Turkish Thoracic Journal;Sep2011, Vol. 12 Issue 3, p105 

    Objective: The aim of this study was to investigate the frequency of obesity in patients with various degrees of severity of OSAS, the prevalance of hypertension (HT), cardiovascular diseases (CVD) and diabetes mellitus (DM) coexisting with OSAS, and the relationship between obesity and these...


Read the Article


Sign out of this library

Other Topics