TITLE

Chromatin dynamics and the preservation of genetic information

AUTHOR(S)
Downs, Jessica A.; Nussenzweig, Michel C.; Nussenzweig, André
PUB. DATE
June 2007
SOURCE
Nature;6/21/2007, Vol. 447 Issue 7147, p951
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin — the fibres into which DNA is packaged with a proteinaceous structural polymer — has an important role in initiating, propagating and terminating this cellular response to DNA damage.
ACCESSION #
25463760

 

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