Homocysteine (Hcy) Follow-Up Study

Blum, Arnon; Hijazi, Ihsan; Mashiach Eizenberg, Michal; Blum, Nava
February 2007
Clinical & Investigative Medicine;Feb2007, Vol. 30 Issue 1, p21
Academic Journal
Background: Hyperhomocysteinemia confers an increased risk of coronary artery disease, stroke, and deep vein thrombosis, and is a strong predictor of mortality among patients with ischemic heart disease. Purpose: To determne the long term clinical outcome of patients with risk factors to atherosclerosis with high concentrations of homocysteine (Hcy). Methods: 89 patients with one or more risk factors for atherosclerosis, whose plasma total Hcy concentrations were measured, were followed for 5 years. Patients were interviewed and underwent a clinical examination in the outpatient clinic. Their medical records were reviewed in the last 5 years including smoking habits, medications, other diseases (hypertension, diabetes mellitus, hyperlipidemia) and their management. SPSS was used to describe and explore possible relationships between Hcy concentration, other diseases, medications and the clinical long term outcome. Results: All men with normal Hcy concentrations (10.76±1.71μmol/L) survived during the 5 years' follow up, while 5 of the men with high Hcy concentrations (21.27±5.37μmol/L), died (17%) (P< 0.05). In women Hcy concentration did not affect survival. No association was found between diabetes mellitus, hypercholesterolemia, hypertension and Hcy. Long term treatment with Beta Blockers, ACE inhibitors, Calcium Channel blockers, and especially with Aspirin prevented death and changed the natural history of patients with high Hcy concentrations (P < 0.05). Conclusions - Hyperhomocysteinemia may have an effect on survival in men. Long term treatment with Beta Blockers, ACE inhibitors, Calcium Channel Blockers, and especially with Aspirin - prevented death and changed the natural history of patients with high Hcy concentrations.


Related Articles

  • Association between Hostility and Plasma Total Homocysteine Concentrations in a General Population Sample. Papageorgiou, Charalabos; Pitsavos, Christos; Panagiotakos, Demosthenes B.; Kontoangelos, Kostantinos; Chrysohoou, Christina; Papadimitriou, George N.; Rabavilas, Andreas D. // Neuropsychobiology;2006, Vol. 53 Issue 1, p26 

    Objective: The present study focuses on testing the association of hostility with plasma homocysteine levels in a general population sample. Method: Four hundred and ten healthy adults (200 men and 210 women), participating in a health survey in Greece, had blood samples taken for homocysteine...

  • Heart attacks and homocysteine. Graham, Ian; Meleady, Raymond // BMJ: British Medical Journal (International Edition);12/07/96, Vol. 313 Issue 7070, p1419 

    Editorial. Calls for a randomized controlled trial of plasma homocysteine reduction. Plasma homocysteine concentration estimated to raise the risk of coronary heart disease and myocardial infarction; Absence of clear information on the mechanism of how homocysteine maybe atherogenic; Need to...

  • Association of serum total homocysteine with the extent of ischemic heart disease in a Mediterranean cohort.  // Alternative Medicine Review;Dec2004, Vol. 9 Issue 4, p453 

    Discusses research being done on the association of serum total homocysteine with the extent of ischemic heart disease in a Mediterranean cohort. Reference to a study by G. Vrentzos, J. A. Papadakis, N. Malliaraki et al, published in a 2004 issue of the "Angiology"; Concentrations that increase...

  • Preventable health care, 200 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. Booth, Gillian L.; Wang, Elaine E.L. // CMAJ: Canadian Medical Association Journal;7/11/2000, Vol. 163 Issue 1, p21 

    AbstractObjective: To establish guidelines for the screening and treatment of hyperhomocysteinemia in the investigation and management of coronary artery disease (CAD).Options: Measurement of plasma total homocysteine (tHcy) levels in the fasting state or 4-6 hours after oral methionine load;...

  • Spotting coronary risks among the healthy. Mackety, Carolyn Kramer // RN;Apr75, Vol. 38 Issue 4, p76 

    Discusses research being done on screening for patients at risk of coronary artery disease in a health population at the Swedish American Hospital in Rockford, Illinois. Start of the screening process; Description of the clinical setting; Role of nurses in the screening process.

  • Novel Cardiovascular Risk Factors: Do They Add Value to Your Practice? Mosca, Lori // American Family Physician;1/15/2003, Vol. 67 Issue 2, p264 

    Editorial. Focuses on novel risk factors for coronary heart disease (CHD). Pathophysiology of CHD; Risk of women for CHD; Association between increased levels of homocysteine and CHD.

  • Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease. Nygård, Ottar; Nordrehaug, Jan Erik; Refsum, Helga; Ueland, Per Magne; Farstad, Mikael; Vollset, Stein Emil // New England Journal of Medicine;07/24/97, Vol. 337 Issue 4, p230 

    Background: Elevated plasma homocysteine levels are a risk factor for coronary heart disease, but the prognostic value of homocysteine levels in patients with established coronary artery disease has not been defined. Methods: We prospectively investigated the relation between plasma total...

  • Homocysteine can help in assessing risk of CHD. Hartley, Jo // GP: General Practitioner;5/13/2002, p4 

    Focuses on the study conducted in Ireland regarding the importance of blood homocysteine in assessing coronary heart disease risk factors. Sample size of the study; Link between homocysteine and coronary events in patients with heart disease; Measurement of homocysteine levels to assess the...

  • Higher homocysteine levels in young Indian adults: Impact of vitamin B12 & folate deficiencies. Muftuoglu, Tuba; Ozcan, Omer; Cosar, Alpaslan; Gultepe, Mustafa // Indian Journal of Medical Research;Oct2013, Vol. 138 Issue 4, p562 

    A letter to the editor is presented in response to the article "Role of Homocysteine & MTHFR C677T Gene Polymorphism As Risk Factors for Coronary Artery Disease in Young Indians" by S. K. Gupta and colleagues published in the journal in 2012.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics