TITLE

HLA Polymorphisms and Cervical Human Papillomavirus Infection in a Cohort of Montreal University Students

AUTHOR(S)
Mahmud, Salaheddin M.; Robinson, Keira; Richardson, Harriet; Tellier, Pierre-Paul; Ferenczy, Alex S.; Roger, Michel; Coutlée, François; Franco, Eduardo L.
PUB. DATE
July 2007
SOURCE
Journal of Infectious Diseases;7/1/2007, Vol. 196 Issue 1, p82
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Only a minority of women with human papillomavirus (HPV) infection eventually develop cervical cancer, which suggests that host immune mechanisms play a role in the disease. HLA polymorphisms have been linked to the risk of cervical cancer, but very little is known about the role that they play in the acquisition and persistence of HPV infection. Methods. A cohort study of cervical HPV infections was used to examine the role that 5 HLA alleles (B*07, DQB1*03, DQB1*0602, DRB1*13, and DRB1*1501) play in determining the risk of HPV positivity and persistence in 524 female university students in Montreal. HPV positivity was determined by use of the MY09/11 polymerasechain-reaction protocol. HLA alleles from purified DNA from cervical specimens were typed by use of a polymerasechain-reaction technique using sequence-specific primers. Results. HLA DRB1*13 was associated with cumulative risk of HPV infections (odds ratio [OR], 1.7 [95% confidence interval {CI}, 1.0–2.8]), for oncogenic HPV (OR, 1.6 [95% CI, 0.9–2.8]), and for HPV-16 (OR, 2.0 [95% CI, 0.9–4.4]). DQB1*03 was consistently associated with a lower cumulative risk of HPV infections, but this association was not statistically significant. None of the alleles affected the risk of HPV persistence. Conclusions. The results of this study support the hypothesis that certain HLA class II polymorphisms mediate genetic susceptibility to the acquisition of HPV infection.
ACCESSION #
25368351

 

Related Articles

  • TNF-α Promoter Polymorphisms and Susceptibility to Human Papillomavirus 16-Associated Cervical Cancer. Deshpande, Alma; Nolan, John P.; White, Scott; Valdez, Yolanda E.; Hunt, William C.; Peyton, Cheri L.; Wheeler, Cosette M. // Journal of Infectious Diseases;3/15/2005, Vol. 191 Issue 6, p969 

    Background. Polymorphisms in the TNF-cx promoter region have recently been shown to be associated with susceptibility to cervical cancer. Some polymorphisms have been reported to influence transcription for this cytokine. Altered local levels in the cervix may influence an individual's immune...

  • Ethnic differences in allelic distribution of IFN-g in South African women but no link with cervical cancer. Govan, Vandana A.; Carrara, Henri R. O.; Sachs, Johnny A.; Hoffman, Margaret; Stanczuk, Grazyna A.; Williamson, Anna-Lise // Journal of Carcinogenesis;2003, Vol. 2 Issue 1, p3 

    Background: The failure of specific types of human papillomaviruses (HPV) to raise effective immune responses may be important in the pathogenesis of cervical cancer, the second most common cancer in South African women. Polymorphisms of a number of cytokine genes have been implicated in...

  • OPINION: Immune evasion in human papillomavirus-associated cervical cancer. Tindle, Robert W. // Nature Reviews Cancer;Jan2002, Vol. 2 Issue 1, p59 

    Tumour-associated viruses produce antigens that, on the face of it, are ideal targets for immunotherapy. Unfortunately, these viruses are experts at avoiding or subverting the host immune response. Cervical-cancer-associated human papillomavirus (HPV) has a battery of immune-evasion mechanisms...

  • Common Variants in Immune and DNA Repair Genes and Risk for Human Papillomavirus Persistence and Progression to Cervical Cancer. Wang, Sophia S.; Bratti, M. Concepcion; Rodríguez, Ana Cecilia; Herrero, Rolando; Burk, Robert D.; Porras, Carolina; González, Paula; Sherman, Mark E.; Wacholder, Sholom; Lan, Z. Elizabeth; Schiffman, Mark; Chanock, Stephen J.; Hildesheim, Allan // Journal of Infectious Diseases;1/1/2009, Vol. 199 Issue 1, p20 

    Background. We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer. Methods. We genotyped 92 single-nucleotide polymorphisms...

  • Immune factors involved in the cervical immune response in the HIV/HPV co-infection. Nicol, A. F.; Nuovo, G. J.; Salomão-Estevez, A.; Grinsztein, B.; Tristão, A.; Russomano, F.; Silva, J. R. Lapa; Oliveira, M. P.; Pirmez, C. // Journal of Clinical Pathology;Jan2008, Vol. 61 Issue 1, p84 

    Aims: Immune factors influencing the progression of cervical intraepithelial neoplasia (CIN) to cancer remain poorly defined. This study investigates the expression of RANTES, MIP1α, C0X1, C0X2, STAT3, TGFβRI, IL10R, TNFαRII and TLR4 in the cervical immune response in HIV/ HPV (human...

  • Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant. Ruiz, Wanda; McClements, William L.; Jansen, Kathrin U.; Esser, Mark T. // Journal of Immune Based Therapies & Vaccines;2005, Vol. 3, p2 

    Background: Human papillomaviruses (HPV) are the most common sexually transmitted viruses. Infection of the cervical epithelium by HPVs can lead to the development of cervical cancer. Recent advances in vaccine research have shown that immunization with papillomavirus-like particles (VLPs)...

  • Cellular Immune Responses to Human Papillomavirus (HPV)--16 L1 in Healthy Volunteers Immunized with Recombinant HPV-16 L1 Virus-Like Particles. Pinto, Ligia A.; Edwards, Jessica; Castle, Philip E.; Harro, Clayton D.; Lowy, Douglas R.; Schiller, John T.; Wallace, Dora; Kopp, William; Adelsberger, Joseph W.; aseler, Michael W.; Berzofsky, Jay A.; Hildesheim, Allan // Journal of Infectious Diseases;7/15/2003, Vol. 188 Issue 2, p327 

    The causal association between papillomavirus (HPV) infection and cervical cancer has been demonstrated; the development of a prophylactic vaccine to protect against HPV infection may therefore reduce the incidence of this cancer worldwide. Noninfectious HPV-like particles (VLPs), composed of...

  • HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer. Martin, Maureen P.; Borecki, Ingrid B.; Zhengyan Zhang; Nguyen, Loan; Duanduan Ma; Xiaojiang Gao; Ying Qi; Carrington, Mary; Rader, Janet S. // Immunogenetics;Dec2010, Vol. 62 Issue 11/12, p761 

    Inherited genetic polymorphisms within immune response genes have been shown to associate with risk of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grade 3. Here, we used the transmission/disequilibrium test to detect disease-liability alleles...

  • Population-based study on the prevalence of and risk factors for human papillomavirus infection in Qujing of Yunnan province, Southwest China. Sun Lu-lu; Jin Qiong; Li Hui; Zhou Xian-rong; Song Zhi-qin; Cheng Xue-mei; Tao Tao; Liang Bing; Xu Lin; Wang Yu-rong; Zhen Yan; He Ji-wen; Shen Keng // Virology Journal;2012, Vol. 9 Issue 1, p153 

    Background: Human papillomavirus (HPV) infection causes cervical cancer and premalignant lesions of the cervix. Prevalence of HPV infection and HPV genotypes vary among different regions. However there is no data on the prevalence of HPV infection and HPV genotypes from southwest China. This...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics