TITLE

Molecular Epidemiology of Adenovirus Type 4 Infections in US Military Recruits in the Postvaccination Era (1997—2003)

AUTHOR(S)
Kajon, Adriana E.; Moseley, Jennifer M.; Metzgar, David; Huo-Shu Huong; Wadleigh, Aya; Ryan, Margaret A. K.; Russell, Kevin L.
PUB. DATE
July 2007
SOURCE
Journal of Infectious Diseases;7/1/2007, Vol. 196 Issue 1, p67
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Military recruits are at a higher risk of respiratory infection than their civilian counterparts. Continuous outbreaks of adenovirus (Ad)—associated acute respiratory disease were documented among US trainees before the implementation of serotype 4 (Ad4) and serotype 7 vaccines in 1971. The discontinuation of Ad vaccination programs in 1999 precipitated the reemergence of Ad in training sites, with Ad4 accounting for 98% of all diagnosed cases. Methods. A total of 724 Ad4 strains isolated from recruits presenting with febrile respiratory illness at 8 training sites nationwide between 1997 and 2003 were genome typed by restriction enzyme analysis. Results. Seven genome types were identified, all of which were distinct from the prototype Ad4p and the vaccine type 4p1. Results showed very different, and often stable, genome type distributions at different geographic sites, despite the homogeneity of the recruit source population. Conclusions. The data support the hypothesis that reservoirs for Ad outbreaks are within recruit training sites or in their immediate environments, not in the incoming recruit population. Molecular characterization beyond serotype is critical to understanding the transmission dynamics of Ad infection in these unique susceptible populations and to the implementation of effective prevention approaches.
ACCESSION #
25368349

 

Related Articles

  • High-Incidence of Human Adenoviral Co-Infections in Taiwan. Wang, Shan-Li; Chi, Chia-Yu; Kuo, Pin-Hwa; Tsai, Huey-Pin; Wang, Shih-Min; Liu, Ching-Chuan; Su, Ih-Jen; Wang, Jen-Ren // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan. Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the...

  • Adenovirus type 7 associated with severe and fatal acute lower respiratory infections in Argentine children. Carballal, Guadalupe; Videla, Cristina; Misirlian, Alicia; Requeijo, Paula V.; Aguilar, María del Carmen // BMC Pediatrics;2002, Vol. 2, p6 

    Background: Adenoviruses are the second most prevalent cause of acute lower respiratory infection of viral origin in children under four years of age in Buenos Aires, Argentina. The purpose of this study was to analyze the clinical features and outcome of acute lower respiratory infection...

  • Antigenic variability among two subtypes of human adenovirus serotype 7. Tian, Xingui; Su, Xiaobo; Xue, Chunyan; Li, Xiao; Zhou, Zhichao; Zhou, Rong // Virus Genes;Aug2014, Vol. 49 Issue 1, p22 

    Human adenovirus type 7 (HAdV-7) is one of the major serotypes responsible for acute respiratory infection. It is important to investigate the antigenic variabilities of different HAdV-7 genomic subtypes for vaccine development. Phylogenetic analysis of global HAdV-7 strains and major antigen...

  • Structural Bone Deficits in HIV/HCVCoinfected, HCV-Monoinfected, and HIVMonoinfected Women. Kajon, Adriana E.; Jun Hang; Hawksworth, Anthony; Metzgar, David; Hage, Elias; Hansen, Christian J.; Kuschner, Robert A.; Blair, Patrick; Russell, Kevin L.; Jarman, Richard G. // Journal of Infectious Diseases;9/15/2015, Vol. 212 Issue 6, p924 

    Background: Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is associated with reduced bone mineral density (BMD) and increased fracture rates, particularly in women. The structural underpinnings for skeletal fragility in coinfected women have not been...

  • A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine. Qurei, Lina; Seto, Donald; Salah, Zaidoun; Azzeh, Maysa; Kremer, Eric J. // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    A molecular epidemiology survey was performed in order to establish and document the respiratory adenovirus pathogen profiles among children in Southern Palestine. Three hundred and thirty-eight hospitalized pediatric cases with adenovirus-associated respiratory tract infections were...

  • New Technology.  // Healthcare Purchasing News;Mar2009, Vol. 33 Issue 3, p50 

    This section offers medical news briefs. Vaccine has been developed for preventing uncommon cold or human adenovirus type-3 which is associated with illnesses such as conjunctivitis, upper respiratory infections, pneumonia and gastrointestinal disease. The U.S. government has already given...

  • Genetic Variation in Attachment Glycoprotein Genes of Human Respiratory Syncytial Virus Subgroups A and B in Children in Recent Five Consecutive Years. Cui, Guanglin; Zhu, Runan; Qian, Yuan; Deng, Jie; Zhao, Linqing; Sun, Yu; Wang, Fang // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Human respiratory syncytial virus (HRSV) outranks other viral agents as the cause of respiratory tract diseases in children worldwide. Molecular epidemiological study of the virus provides useful information for the development of globally effective vaccine. We investigated the circulating...

  • Molecular epidemiology of subgenus F adenoviruses associated with pediatric gastroenteritis during eight years in Hiroshima Prefecture as a limited area. Fukuda, S.; Kuwayama, M.; Takao, S.; Shimazu, Y.; Miyazaki, K. // Archives of Virology;Dec2006, Vol. 151 Issue 12, p2511 

    We have studied the prevalence of the subgenus F adenoviruses and the molecular characteristics of adenovirus type 41 in Hiroshima Prefecture, Japan, as a limited area during the period of 1997–2004. Subgenus F adenoviruses were detected in 30 (3.4%) of 892 fecal specimens by enzyme...

  • Common Lineage Suggested for Viruses That Infect Hosts From All Three Domains of Life.  // Ascribe Newswire: Medicine;12/2/2004, p7 

    The article focuses on a study on the structural similarities among viruses that infect hosts from all three domains of life. these structural similarities suggest that the viruses, despite their genomic variations and differences in hosts, may have evolved from a common ancestor billions of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics