TITLE

Defining and investigating occupational asthma: a consensus approach

AUTHOR(S)
Francis, H. C.; Prys-Picard, C. O.; Fishwick, D.; Stenton, C.; Burge, P. S.; Bradshaw, L. M.; Ayres, J. G.; Campbell, S. M.; Niven, R. McL
PUB. DATE
June 2007
SOURCE
Occupational & Environmental Medicine;Jun2007, Vol. 64 Issue 6, p361
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: At present there is no internationally agreed definition of occupational asthma and there is a lack of guidance regarding the resources that should be readily available to physicians running specialist occupational asthma services. Aims: To agree a working definition of occupational asthma and to develop a framework of resources necessary to run a specialist occupational asthma clinic. Method: A modified RAND appropriateness method was used to gain a consensus of opinion from an expert panel of clinicians running specialist occupational asthma clinics in the UK. Results: Consensus was reached over 10 terms defining occupational asthma including: occupational asthma is defined as asthma induced by exposure in the working environment to airborne dusts vapours or fumes, with or without pre-existing asthma; occupational asthma encompasses the terms ‘sensitiser-induced asthma’ and ‘acute irritant-induced asthma’ (reactive airways dysfunction syndrome (RADS)); acute irritant- induced asthma is a type of occupational asthma where there is no latency and no immunological sensitisation and should only be used when a single high exposure has occurred; and the term ‘work-related asthma’ can be used to include occupational asthma, acute irritant-induced asthma (RADS) and aggravation of pre-existing asthma. Disagreement arose on whether low dose irritant-induced asthma existed, but the panel agreed that if it did exist they would include it in the definition of ‘work-related asthma’. The panel agreed on a set of 18 resources which should be available to a specialist occupational asthma service. These included pre-bronchodilator FEy1 and FVC (% predicted); peak flow monitoring (and plotting of results, OASYS II analysis); non-specific provocation challenge in the laboratory and specific IgE to a wide variety of occupational agents. Conclusion: It is hoped that the outcome of this process will improve uniformity of definition and investigation of occupational asthma across the UK.
ACCESSION #
25351677

 

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