TITLE

Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study

AUTHOR(S)
Penders, John; Thijs, Carel; van den Brandt, Piet A.; Kummeling, Ischa; Snijders, Bianca; Stelma, Foekje; Adams, Hanne; van Ree, Ronald; Stobberingh, Ellen E.
PUB. DATE
May 2007
SOURCE
Gut;May2007, Vol. 56 Issue 5, p661
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: Perturbations in intestinal microbiota composition due to lifestyle changes may be involved in the development of atopic diseases. We examined gut microbiota composition in early infancy and the subsequent development of atopic manifestations and sensitisation. Methods: The faeces of 957 infants aged 1 month and participating in the KOALA Birth Cohort Study were analysed using quantitative real-time PCR. Information on atopic symptoms (eczema, wheeze) and potential confounders was acquired through repeated questionnaires. Total and specific IgE were measured in venous blood samples collected during home visits when the infant was 2 years old. During these home visits a clinical diagnosis of atopic dermatitis was made according to the UK-Working Party criteria. Results: The presence of Escherichia coli was associated with a higher risk of developing eczema (ORadj = 1.87; 95% CI 1.15 to 3.04), this risk being increased with increasing numbers of E coli (pfortrend=0.016). Infants colonised with Clostridium difficile were at higher risk of developing eczema (ORadj = 1.40; 95% CI 1.02 to 1.91 ), recurrent wheeze (ORadj = 1.75; 95% CI 1.09 to 2.80) and allergic sensitisation (ORadj = 1.54; 95% CI 1.02 to 2.31). Furthermore, the presence of C difficile was also associated with a higher risk of a diagnosis of atopic dermatitis during the home visit (ORadj = 1.73; 95% CI 1.08 to 2.78). Conclusion: This study demonstrates that differences in gut microbiota composition precede the development of atopy. Since E coli was only associated with eczema and C difficile was associated with all atopic outcomes, the underlying mechanisms explaining these association may be different.
ACCESSION #
25298729

 

Related Articles

  • Absence of Pathogens in Intestinal Tissue of Patients with Necrotizing Enterocolitis. Winslow, Dean L. // Hospital Medicine Alert;Mar2012, Vol. 7 Issue 1, p3 

    The article presents a reprint of the article "Absence of Pathogens in Intestinal Tissue of Patients with Necrotizing Enterocolitis," by Dean L. Winslow, which appeared in the February 2012 issue of "Infectious Disease Alert." It discusses a study which detects bacterial and viral pathogens in...

  • Archival PCR-based diagnosis of Clostridium difficile in piglets. Jung, K.; Ha, S.-K.; Chung, H.-K.; Kim, J.; Cho, W.-S.; Choi, C.; Chae, C. // Veterinary Record: Journal of the British Veterinary Association;10/11/2003, Vol. 153 Issue 15, p466 

    Discusses the use of polymerase chain reaction diagnosing Clostridium difficile in piglets. Classical methods for the detection of Clostridium difficile toxins; Exfoliation of enterocytes; Exudation of fibrin and neutrophils into the colonic lumen; Isolation of toxigenic Clostridium difficile...

  • Erratum: Polymerase chain reaction ribotyping of Clostridium difficile isolates in Qatar: a hospital-based study.  // BMC Infectious Diseases;2015, Vol. 15 Issue 1, p1 

    A correction to the article "Polymerase chain reaction ribotyping of Clostridium difficile isolates in Qatar: a hospital-based study" by Asma a Al-Thani et al., published online on April 3, 2015 is presented.

  • Clostridium difficile Ribotype 027, Toxinotype III, the Netherlands. Kuijper, Ed J.; van den Berg, Renate J.; Debast, Sylvia; Visser, Caroline E.; Veenendaal, Dick; Troelstra, Annet; van der Kooi, Tjallie; van den Hof, Susan; Notermans, Daan W. // Emerging Infectious Diseases;May2006, Vol. 12 Issue 5, p827 

    Reports on the detection of outbreaks due to Clostridium (C.) difficile polymerase chain reaction ribotype 027, toxinotype III in seven hospitals in the Netherlands from April 2005 to February 2006. Account of similar outbreaks of C. difficile cases in Canada and the U.S.; Identification of the...

  • Primus inter pares (First among equals). Keck, James L.; Berger, James M. // Nature Structural Biology;Jan2001, Vol. 8 Issue 1, p2 

    Focuses on the structures of the Escherichia coli DnaG catalytic core and the Pyrococcus furiosus primase subunit which offer a chance to compare and contrast these two families of polymerases and help answer questions that surround general priming mechanisms. Primase structure; Mechanism of...

  • Mislabelled cow's milk allergy in infants: a prospective cohort study. Elizur, Arnon; Cohen, Michal; Rajuan, Nelly; Katz, Yitzhak // Archives of Disease in Childhood;Jun2013, Vol. 98 Issue 6, p408 

    Background Although cow's milk allergy (CMA) is one of the most common food allergies, mislabelling nonallergic infants as being allergic to cow's milk is more common. Despite this, characteristics of families and infants with mislabelled CMA are lacking. Methods Using a prospective...

  • Shiga Toxin--Producing Escherichia coli in Montana: Bacterial Genotypes and Clinical Profiles. Jelacic, Jill K.; Damrow, Todd; Chen, Gilbert S.; Jelacic, Srdjan; Bielaszewska, Martina; Ciol, Marcia; Carvalho, Humberto M.; Melton-Celsa, Angela R.; O'Brien, Alison D.; Tarr, Phillip I. // Journal of Infectious Diseases;9/1/2003, Vol. 188 Issue 5, p719 

    The diseases and virulence genes associated with Shiga toxin-producing Escherichia coli (STEC) are characterized incompletely. We analyzed, by polymerase chain reaction, 82 STEC isolates collected prospectively in Montana and profiled associated illnesses by patient chart review. All E. coli...

  • A Real-Time Polymerase Chain Reaction Based Assay for the Detection of Escherichia coli in Patients with Urinary Tract Infection in the Sudan.  // Current Research in Bacteriology;2010, Vol. 3 Issue 3, p164 

    An abstract of the article "A Real-Time Polymerase Chain Reaction Based Assay for the Detection of Escherichia coli in Patients with Urinary Tract Infection in the Sudan," by Humodi A. Saeed, Zahra K. Yousif, Mugahid M. El Hassan, Misk El Yamen, A. Atti and Mansour M. Mansour is presented.

  • Improved Detection of Enterotoxigenic Escherichia coli among Patients with Travelers' Diarrhea, by Use of the Polymerase Chain Reaction Technique. Caeiro, Juan-Pablo; Estrada-Garcia, M. Teresa; Jiang, Zhi-Dong; Mathewson, John J.; Adachi, Javier A.; Steffen, Robert // Journal of Infectious Diseases;12/1/99, Vol. 180 Issue 6, p2053 

    This study sought to determine whether a specific polymerase chain reaction (PCR) for enterotoxigenic Escherichia coli (ETEC) toxins after chaotropic extraction of DNA from stool would increase the detection of ETEC over that of conventional oligonucleotide probe hybridization of 5 E. coli...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics