Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection

Thursz, Mark
May 2007
Gut;May2007, Vol. 56 Issue 5, p613
Academic Journal
The article comments on the paper about the significance of hemoglobin Î’ mutations in the development of hepatic iron overload and fibrosis in patients with chronic hepatitis C virus infection. The author stresses that the prevalence of such mutation than what is expected in the patient may result of a bias presented by using a clinic-based population. He stresses that the difference in the effect of hereditary hemochromatosis and Î’-globin mutations emphasize the role of iron.


Related Articles

  • Role of CCR5Δ32 mutation in protecting patients with Schistosoma mansoni infection against hepatitis C viral infection or progression. El-Moamly, Amal; El-Sweify, Mohamed; Rashad, Rafiaa; Abdalla, Esam; Ragheb, Mostafa; Awad, Mohamed // Parasitology Research;Jul2013, Vol. 112 Issue 7, p2745 

    Schistosomiasis has been incriminated in the significant increase in hepatitis C virus (HCV) infections, although the association has not been adequately explained. We hypothesized that the CCR5Δ32 mutation may be involved in the high prevalence of HCV with schistosomiasis. The aim was to...

  • Let-7b is a novel regulator of hepatitis C virus replication. Cheng, Ju-Chien; Yeh, Yung-Ju; Tseng, Ching-Ping; Hsu, Sheng-Da; Chang, Yu-Ling; Sakamoto, Naoya; Huang, Hsien-Da // Cellular & Molecular Life Sciences;Aug2012, Vol. 69 Issue 16, p2621 

    The non-coding microRNA (miRNA) is involved in the regulation of hepatitis C virus (HCV) infection and offers an alternative target for developing anti-HCV agent. In this study, we aim to identify novel cellular miRNAs that directly target the HCV genome with anti-HCV therapeutic potential....

  • Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus. Poon, Art F. Y.; Pond, Sergei L. Kosakovsky; Bennett, Phil; Richman, Douglas D.; Brown, Andrew J. Leigh; Frost, Simon D. W. // PLoS Pathogens;Mar2007, Vol. 3 Issue 3, p0409 

    CD8+ cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). As a result, genetic variation at CTL epitopes is strongly influenced by host-specific...

  • Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses. Honegger, Jonathan R; Kim, Seungtaek; Price, Aryn A; Kohout, Jennifer A; McKnight, Kevin L; Prasad, Mona R; Lemon, Stanley M; Grakoui, Arash; Walker, Christopher M // Nature Medicine;Nov2013, Vol. 19 Issue 11, p1529 

    Globally, about 1% of pregnant women are persistently infected with the hepatitis C virus (HCV). Mother-to-child transmission of HCV occurs in 3-5% of pregnancies and accounts for most new childhood infections. HCV-specific CD8+ cytotoxic T lymphocytes (CTLs) are vital in the clearance of acute...

  • Single Strain Isolation Method for Cell Culture-Adapted Hepatitis C Virus by End-Point Dilution and Infection. Sugiyama, Nao; Murayama, Asako; Suzuki, Ryosuke; Watanabe, Noriyuki; Shiina, Masaaki; Liang, T. Jake; Wakita, Takaji; Kato, Takanobu // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    The hepatitis C virus (HCV) culture system has enabled us to clarify the HCV life cycle and essential host factors for propagation. However, the virus production level of wild-type JFH-1 (JFH-1/wt) is limited, and this leads to difficulties in performing experiments that require higher viral...

  • Genotype 1 Hepatitis C Virus Envelope Features That Determine Antiviral Response Assessed through Optimal Covariance Networks. Murray, John M.; Moenne-Loccoz, Rémy; Velay, Aurélie; Habersetzer, François; Doffoël, Michel; Gut, Jean-Pierre; Fofana, Isabel; Zeisel, Mirjam B.; Stoll-Keller, Françoise; Baumert, Thomas F.; Schvoerer, Evelyne // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    The poor response to the combined antiviral therapy of pegylated alfa-interferon and ribavarin for hepatitis C virus (HCV) infection may be linked to mutations in the viral envelope gene E1E2 (env), which can result in escape from the immune response and higher efficacy of viral entry. Mutations...

  • 3-Drug Synergistic Interactions of Small Molecular Inhibitors of Hepatitis C Virus Replication. Grünberger, Christian; Wyles, David L.; Kaihara, Kelly A.; Schooley, Robert T. // Journal of Infectious Diseases;1/1/2008, Vol. 197 Issue 1, p42 

    Small molecular inhibitors of hepatitis C virus (HCV) replication provide remarkable potency, but the rapid selection of resistance mutations will require that these agents be used in combination for clinical treatment. Using a model HCV replicon system, we have extended prior in vitro studies...

  • Increased Hepatitis C Virus Load among Injection Drug Users Infected with Human Immunodeficiency Virus and Human T Lymphotropic Virus Type II. Hisada, Michie; Chatterjee, Nilanjan; Mingdong Zhang, Nilanjan; Battjes, Robert J.; Goedert, James J. // Journal of Infectious Diseases;9/15/2003, Vol. 188 Issue 6, p891 

    Examines an increased hepatitis C virus load among injection drug users infected with human immunodeficiency and T lymphotropic virus type II. Comparison of hepatitis C virus coinfection ribonucleic acid (HCV RNA) detection and load in research subjects; Relation of HVC RNA to sex, race, and...

  • The epidemiology of hepatitis C infection in the United States. Rustgi, Vinod K. // Journal of Gastroenterology;Jul2007, Vol. 42 Issue 7, p513 

    The prevalence of hepatitis C virus (HCV) infection in the United States has remained constant from 1988 through 2002, although the peak age of infection has increased. While the number of new HCV cases is declining, the rates of HCV-associated morbidity and mortality are increasing. We reviewed...


Read the Article


Sign out of this library

Other Topics