Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1

Pritchard, D. M.
May 2007
Gut;May2007, Vol. 56 Issue 5, p606
Academic Journal
The article comments on the paper which discusses the pathogenesis of endocrine tumors in patients with multiple endocrine neoplasia type 1 (MEN1). It was found that those patients with MEN1 display germline mutations. The author stresses that the appearance of multiple tumors in susceptible patients arises as a result of such mutation in the MEN1 gene. He questions the cause of hyperplasia of gastrin-secreting and somatostatin-secreting cells in the duodenums of patients with MEN1.


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