TITLE

Hydride generation activity of arsenosugars and thioarsenicals

AUTHOR(S)
Regmi, Rajendra; Milne, Bruce F.; Feldmann, Jörg
PUB. DATE
June 2007
SOURCE
Analytical & Bioanalytical Chemistry;Jun2007, Vol. 388 Issue 4, p775
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The major arsenosugar compounds have been reported to be hydride-generation-active, however to a lesser extent in comparison with the inorganic arsenicals. We report here for the first time the identity and quantity of the volatile arsenicals generated by As-sugar-SO3, As-sugar-SO4, dimethylarsinoyl acetic acid and dimethylarsinoyl ethanol. Only one major volatile compound was identified for all four compounds studied: dimethylarsine. This means that the As–C bond to the longer carbon chain was cleaved during the hydride-generation process. Theoretical calculations at the RHF/6-31G(d,p) ab initio level confirm that this As–C bond is much weaker than the As–CH3 bonds. Furthermore, it was revealed that the sulphur analogue of dimethylarsinic acid (DMAS ) is hydride-generation-active at pH 7 in contrast to dimethylarsinic acid, despite the fact that arsenic is also pentavalent. This has been substantiated by the calculation of the change in susceptibility of the arsenic towards nucleophilic attack when oxygen is replaced by sulphur. Hence, DMAS can easily be mistaken for a trivalent arsenic species.
ACCESSION #
25277592

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics