TITLE

Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

AUTHOR(S)
Castiglione, G.; Visioli, C. B.; Ciatto, S.; Grazzini, G.; Bonanomi, A. G.; Rubeca, T.; Mantellini, P.; Zappa, M.
PUB. DATE
June 2007
SOURCE
British Journal of Cancer;6/4/2007, Vol. 96 Issue 11, p1750
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We evaluated the sensitivity for colorectal cancer (CRC) of the latex agglutination test (LAT), an immunochemical test routinely used in the Florence District screening programme since 2000. Sensitivity was calculated by the proportional interval cancer incidence method in a population of 27 503 consecutive subjects screened in 2000–2002, interval cancers being identified by linkage to the Tuscany Cancer Registry files. Sensitivity was calculated overall and by gender, age, time since last negative LAT, CRC site, and rank of screening. Overall 1- and 2-year sensitivity estimates were 80.7 and 71.5%, respectively, suggesting that faecal occult blood testing screening sensitivity may be suboptimal due to testing or programme quality problems. Increasing screening sensitivity might be achieved if the detection rate of advanced adenomas could be increased without unacceptable loss in specificity.British Journal of Cancer (2007) 96, 1750–1754. doi:10.1038/sj.bjc.6603759 www.bjcancer.com Published online 24 April 2007
ACCESSION #
25210312

 

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