Genetics of essential tremor

Hao Deng; Weidong Le; Joseph Jankovic
June 2007
Brain: A Journal of Neurology;Jun2007, Vol. 130 Issue 6, p1456
Academic Journal
Essential tremor (ET), the cause of which remains poorly understood, is one of the most common neurological disorders. While environmental agents have been proposed to play a role, genetic factors are believed to contribute to its onset. Thus far, three gene loci (ETM1 on 3q13, ETM2 on 2p24.1 and a locus on 6p23) have been identified in patients and families with the disorder. In addition, a Ser9Gly variant in the dopamine D3 receptor gene on 3q13 has been suggested to be a risk factor. Moreover, genetically deficient animal models express a phenotype that overlaps with some clinical characteristics of the human form of the illness. Further analyses of these genetic abnormalities may lead to the identification of causative mutations and a better understanding of the molecular mechanisms in this common movement disorder.


Related Articles

  • Rodent models of tremor. Miwa, Hideto // Cerebellum;Mar2007, Vol. 6 Issue 1, p66 

    This review focuses on rodent models of tremor, particularly those induced by pharmacological agents. Harmaline is one of the most frequently used tremor-generating drugs and harmaline-induced tremor is regarded as a model of essential tremor. Harmaline acts on inferior olive neurons, causing...

  • CITATIONS AND CLINICIANS' NOTES: MOVEMENT DISORDERS.  // Current Medical Literature: Neurology;2004, Vol. 20 Issue 4, p84 

    This article reports on various studies related to movement disorders. One of them is the natural history and syndromic associations of orthostatic tremor: a review of 41 patients. The researchers managed to find 41 patients who fulfilled the diagnosis of orthostatic tremor; 31 had the pure...

  • Surgical treatment of cortical tremor. Ogungbo, Biodun; Rodriguez-Rubio, David; Gholkar, Anil; Mendelow, David // Journal of the Royal Society of Medicine;Jun2001, Vol. 94 Issue 6, p301 

    The article presents a case report involving a 50-year-old woman who sought because of continuous shaking of her left hand that interfered with her daily life. She was diagnosed to have cortical tremor, a disease easily mistaken for parkinsonism. Researchers stress that ablation of the...

  • Linking LINGO1 to essential tremor. Eng-King Tan // European Journal of Human Genetics;Jul2010, Vol. 18 Issue 7, p739 

    The article offers information on essential tremor (ET) as one of the most common neurological condition which is stated to be characterized by postural and action tremor. It states that the first genomewide association study (GWAS) in ET discovered a sequence variant of LINGO1 gene and...

  • Updated guidelines for treating essential tremor. Sibal, Meg // Filipino Reporter;7/6/2012, Vol. 40 Issue 31, p25 

    The article discusses the updated guidelines for treating essential tremor as of July 2012. According to the author, essential tremor is a common movement disorder initially manifested by an up-and-down rapid shaking of the hands which can also affect the head, voice, arms, or even the legs. The...

  • Ocular flutter in essential tremor: clinical course and response to primidone. Anagnostou, Evangelos; Kararizou, Evangelia; Evdokimidis, Ioannis // Journal of Neurology;Oct2013, Vol. 260 Issue 10, p2672 

    The article explores the case of a 74-year-old woman diagnosed with essential tremor, who presented with ocular flutter. Upon diagnosis, the patient was found to have postural tremor of both hands that is more pronounced on the left and her eyes showed infrequent, rapid, conjugate, horizontal...

  • Personality in essential tremor: further evidence of non- motor manifestations of the disease. Chaiterjee, A.; Jurewicz, E. C.; Applegate, L. M.; Louis, E. D. // Journal of Neurology, Neurosurgery & Psychiatry;Jul2004, Vol. 75 Issue 7, p958 

    Objective: To ascertain whether patients with essential tremor have distinct definable personality traits. Methods: A case-control study of patients with essential tremor was carried out to look for differences in personality characteristics. The controls were derived from the same source...

  • Clinical characteristics of essential tremor in Mersin, Turkey. Dogu, Okan; Louis, Elan D.; Sevim, Serhan; Kaleagasi, Hakan; Aral, Mthriban // Journal of Neurology;May2005, Vol. 252 Issue 5, p570 

    To describe the clinical features of essential tremor (ET) in a population. With few exceptions, clinical data on ET are derived from patients who attend specialty clinics. Most (>90 %) population-dwelling ET cases do not seek neurological attention. 89 ET cases living in the Mersin province,...

  • A clinical study of non-parkinsonian and non-cerebellar tremor at a specialty movement disorders clinic. Shukla, Garima; Behari, Madhuri // Neurology India;Jun2004, Vol. 52 Issue 2, p200 

    Background: No Indian studies have focused on the clinical aspects of tremor. Aims: To study the distribution of various etiological types of tremor disorders at a Movement Disorders clinic of a large, tertiary care hospital in India and to study the clinical characteristics of essential tremor...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics