TITLE

A new depression scale designed to be sensitive to change

AUTHOR(S)
Montgomery, Stuart A.; Åsberg, Marie; Montgomery, S A; Asberg, M
PUB. DATE
April 1979
SOURCE
British Journal of Psychiatry;Apr79, Vol. 134, p382
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described. Ratings of 54 English and 52 Swedish patients on a 65 item comprehensive psychopathology scale were used to identify the 17 most commonly occurring symptoms in primary depressive illness in the combined sample. Ratings on these 17 items for 64 patients participating in studies of four different antidepressant drugs were used to create a depression scale consisting of the 10 items which showed the largest changes with treatment and the highest correlation to overall change. The inner-rater reliability of the new depression scale was high. Scores on the scale correlated significantly with scores on a standard rating scale for depression, the Hamilton Rating Scale (HRS), indicating its validity as a general severity estimate. Its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change. The practical and ethical implications in terms of smaller sample sizes in clinical trials are discussed.
ACCESSION #
25205869

 

Related Articles

  • Validity of the Hamilton Rating Scale for depression. Knesevich, J. W.; Biggs, J. T.; Clayton, P. J.; Ziegler, V. E. // British Journal of Psychiatry;Jul77, Vol. 131, p49 

    In 26 depressed patients, a high correlation (0-89) was found between the Hamilton score and a psychiatrist's global rating and between the change (0-68) in these ratings during treatment. The Hamilton scale was able to differentiate at the o-01 level four degrees of severity based on the global...

  • Effective Treatment for Depression: St. John's Wort.  // Annals of the American Psychotherapy Association;Winter2008, Vol. 11 Issue 4, p7 

    The article presents information on a study which examined the therapeutic use of St. John's wort for treating mental depression. Participants of the study were asked to rate the severity of their depression after taking various treatments, using the Hamilton Rating Scale for Depression. The...

  • Negative and depressive symptoms in schizophrenia. Kulhara, P.; Avasthi, A.; Chadda, R.; Chandiramani, K.; Mattoo, S. K.; Kota, S. K.; Joseph, S. // British Journal of Psychiatry;Feb89, Vol. 154, p207 

    Ninety-five schizophrenic patients were assessed using the Present State Examination, the Brief Psychiatric Rating Scale and the Scale for the Assessment of Negative Symptoms. Negative and depressive symptoms were frequent, and significant relationships among negative symptom complexes and...

  • Fibromiyaljide EMDR'nin etkinliÄŸinin araÅŸtırılması: Yedi olguyu içeren bir klinik çalışma. Kavakci, Önder; Semİz, Murat; Kaptanoğlu, Ece; Özer, Zafer // Anatolian Journal of Psychiatry / Anadolu Psikiyatri Dergisi;Jan2012, Vol. 13 Issue 1, p75 

    Objective: Fibromyalgia syndrome (FMS) is a nonarticular rheumatic disease with unknown etiology and is characterized by widespread pain, increased tenderness in some anatomical regions, increased pain sensitivity, sleep disorders, fatigue and frequently by psychological distress. Though many...

  • A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF). Jones, Steven H.; Thornicroft, Graham; Coffey, Michael; Dunn, Graham; Jones, S H; Thornicroft, G; Coffey, M; Dunn, G // British Journal of Psychiatry;May95, Vol. 166, p654 

    Background: The Global Assessment of Functioning (GAF) is a quick and simple measure of overall psychological disturbance. However, there is little research on the reliability and validity of this measure in severely mentally ill populations.Method: Multidisciplinary...

  • Paranoid and withdrawal symptoms in schizophrenia: relationship to reaction time. Goldberg, Solomon C.; Schooler, Nina R.; Mattsson, Nils; Goldberg, S C; Schooler, N R; Mattsson, N // British Journal of Psychiatry;Sep68, Vol. 114 Issue 514, p1161 

    The article presents a study that examines relationship of paranoid and withdrawal symptoms to reaction time. In this study, 480 schizophrenic patients were evaluated prior to treatment and after five treatment weeks by the In-patients Multi-dimensional Psychiatric Scale and by the Ward Behavior...

  • Yatarak tedavi gören psikiyatri hastalarında iÅŸlevselliÄŸin genel deÄŸerlendirilmesi ve iliÅŸkili etkenler: Geriye dönük bir çalışma. KIRPINAR, İsmet; ORAL, Meltem // Anatolian Journal of Psychiatry / Anadolu Psikiyatri Dergisi;Sep2012, Vol. 13 Issue 3, p198 

    Objective: Axis V in the DSM classification system uses The Global Assessment of Functioning Scale (GAF) to assess the levels of functional impairment due to by Axis I and Axis II disorders. However, GAF considers social, occupational and psychological functioning as a whole and therefore...

  • A Network View on Psychiatric Disorders: Network Clusters of Symptoms as Elementary Syndromes of Psychopathology. Goekoop, Rutger; Goekoop, Jaap G. // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Introduction: The vast number of psychopathological syndromes that can be observed in clinical practice can be described in terms of a limited number of elementary syndromes that are differentially expressed. Previous attempts to identify elementary syndromes have shown limitations that have...

  • Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. Serretti, A.; Zanardi, R.; Rossini, D.; Cusin, C.; Lilli, R.; Smeraldi, E. // Molecular Psychiatry;2001, Vol. 6 Issue 5, p586 

    Studies the influence of trytophan hydroxylase (TPH) and serotonin transporter genes on fluvoxamine antidepressant activity. Assessment of the severity of depressive symptoms with the Hamilton Rating Scale for Depression; Determination of TPH allelic variants by using a PCR-based technique;...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics