Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas

Courtney, E.; Matthews, S.; Finlayson, C.; Pierro, D.; Belluzzi, A.; Roda, E.; Kang, J.; Leicester, R.
July 2007
International Journal of Colorectal Disease;Jul2007, Vol. 22 Issue 7, p765
Academic Journal
Omega-3 fatty acids in fish oil exert a protective effect on the development of colorectal cancer in animal models. Patients with colorectal adenomas have been shown to have increased crypt cell proliferation and decreased apoptosis in macroscopically normal appearing colonic mucosa. We investigated whether dietary supplementation with eicosapentaenoic acid (EPA) could alter crypt cell proliferation and apoptosis in such patients. Thirty subjects were randomised to either 3 months of highly purified EPA in free fatty acid form (2 g/day) or to no treatment. Colonic biopsies were taken at the initial colonoscopy and repeated 3 months later, and analysed for cell proliferation and apoptosis (immunohistochemistry) and mucosal fatty acid content. Crypt cell proliferation was significantly reduced whilst apoptosis was significantly increased after EPA supplementation. Neither crypt cell proliferation nor apoptosis were altered in the control group. EPA in the mucosa increased significantly after EPA supplementation, whereas there was no significant change in controls. Dietary supplementation with EPA significantly increases levels of this fatty acid in colonic mucosa, associated with significantly reduced proliferation and increased mucosal apoptosis. Further studies are needed to assess the potential efficacy of EPA supplementation in preventing polyps in the chemoprevention of colorectal cancer.


Related Articles

  • nature's top skin saver. Tweed, Vera // Better Nutrition;Apr2008, Vol. 70 Issue 4, p48 

    The article offers information on the health benefits of fish oils. It cites that the fish oil is considered as the richest source of nutrients and omega-3 fatty acids. It contains two key omega-3 fatty acids such as the eicosapentaenoic acid (RPA) and docosahexaenoic acid (DHA). Other benefits...

  • Fish Oil. Straus, Mary // Whole Dog Journal;Sep2012, Vol. 15 Issue 9, p22 

    The article discusses the benefits of fish oil as an important supplement in a dog's diet. It states that the fish oil provides the Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids, the omega-3 fatty acids which give dogs widespread benefits including improved coat and skin, reduced...

  • Research: DINICOLANTONIO and COLLEAGUES. DINICOLANTONIO // Positive Health;Jul2014, Issue 215, p1 

    Background Multiple trials over the past two decades testing omega-3 polyunsaturated fatty acids (PUFAs), containing eicosapentaenoic acid (EPA) and or docosahexaenoic acid (DHA), have shown substantial benefits for reducing major coronary heart disease (CHD) events, all-cause mortality,...

  • FISH FOOD. Martinotti, Mike // Muscle & Performance;Jun2011, Vol. 3 Issue 6, p69 

    The article discusses fish oil and its benefits on health, physique and performance. Its main components are essential fats known as omega-three fats, the two types being eicosapentaenoic acid and docosahexaenoic acid. With the body unable to produce essential oils on its own, it must be taken...

  • Omega-3 Fatty Acids.  // Total Health;Jan/Feb2006, Vol. 27 Issue 6, p38 

    This article offers information on omega-3 fatty acids (-3 FA). It was only a matter of time that food fortified with -3 FA were expected to come out in the market. Not all -3 FA become equally bioavailable in the body. Docosaheaxenoic acid (DHA) and eicopentaenoic acid (EPA) are FA mainly...

  • Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid from Wickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. Li, Hui; Ma, Xiao-jing; Wang, Shuang; Song, Xin // Biotechnology Letters;Jun2013, Vol. 35 Issue 6, p901 

    Sophorolipids (SLs) were synthesized by Wickerhamiella domercqiae var. sophorolipid CGMCC 1576 grown on fish oil and glucose. They were purified using preparative HPLC and their structures were identified by MS/MS. The yields of total and lactonic SLs were 47 and 19 g l in shake-flasks when fish...

  • fish oil supplements. Tran, Minh-Hai // Better Nutrition;Mar2005, Vol. 67 Issue 3, p64 

    The article focuses on fish oil. As research on the potential health benefits of fish oil accumulates, fish oil supplement sales have skyrocketed. The varied benefits of fish oil are credited to two compounds that are classified as omega-3 fatty acids--eicosapentaenoic acid (EPA) and...

  • The Influence of Fish Oil on Neurological Development and Function. Abu-Ouf, Noran M.; Jan, Mohammed M. // Canadian Journal of Neurological Sciences;Jan2014, Vol. 41 Issue 1, p13 

    Fish oil originates from fish tissue rich in omega-3 fatty acids. These include eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Healthy individuals are advised to consume foods rich in fish oil at least twice a week. However, such intake varies depending on cultural or personal...

  • Levels of n-3 enrichment and Australian consumer sensory panel ratings of lamb meat from sheep supplemented with protected tuna oil for different numbers of weeks. Kitessa, S. M.; Boghossian, V.; Reynolds, J.; Williams, A. J.; Gulati, S. K. // Asia Pacific Journal of Clinical Nutrition;2004 Supplement, Vol. 13, pS80 

    Background- Cost-effective strategies to further enhance the levels of n-3 polyunsaturated fatty acids in red meat require determination of the optimum period of supplementation with dietary lipid supplements and the sensory characteristics of meat from animals under different periods of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics