TITLE

Sharing common factors for self-renewal

AUTHOR(S)
Kritikou, Ekat
PUB. DATE
June 2007
SOURCE
Nature Reviews Molecular Cell Biology;Jun2007, Vol. 8 Issue 6, p425
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports on the relationship of embryonic stem (ES) cells and adult stem cells. It is noted that while ES cells give rise to all cell types in the body, homeostasis is maintained by adult stem cells. It is concluded that embryonic and blood-generating haematopoietic stem cells share a common basis for self-renewal.
ACCESSION #
25149404

 

Related Articles

  • Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Hock, Hanno; Hamblen, Melanie J.; Rooke, Heather M.; Schindler, Jeffrey W.; Saleque, Shireen; Fujiwara, Yuko; Orkin, Stuart H. // Nature;10/21/2004, Vol. 431 Issue 7011, p1002 

    Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts. In steady-state, HSCs remain largely quiescent and self-renew at a constant low rate, forestalling their...

  • Use of Human Embryonic Stem Cells to Understand Hematopoiesis and Hematopoietic Stem Cell Niche. Islam, Mohammad Saiful; Ni, Zhenya; Kaufman, Dan S. // Current Stem Cell Research & Therapy;Sep2010, Vol. 5 Issue 3, p245 

    Intensive research of hematopoiesis using human embryonic stem cells (hESC) as a unique starting cell population has enabled differentiation and isolation of diverse hematopoietic cell lineages. However, there has been only limited success in derivation of hematopoietic stem cells (HSCs) capable...

  • ASPECTS OF STIMULATION OF BONE MARROW COLONY GROWTH IN VITRO. Bradley, T. R. // Australian Journal of Experimental Biology & Medical Science;Jun1968, Vol. 46 Issue 3, p335 

    This article describes the stimulation of colony growth of mouse bone marrow cells in vitro by non-irradiated feeder layers of mouse kidney or embryo cells. In this study, no attempt was made to compare the activities of cells from kidneys of mice of other ages. Little or no colony production...

  • Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration. Herranz, Antonio S.; Gonzalo-Gobernado, Rafael; Reimers, Diana; Asensio, Maria J.; Rodríguez-Serrano, Macarena; Bazán, Eulalia // Current Stem Cell Research & Therapy;Mar2010, Vol. 5 Issue 1, p17 

    In recent decades, there has been considerable amount of information about embryonic stem cells (ES). The dilemma facing scientists interested in the development and use of human stem cells in replacement therapies is the source of these cells, i.e. the human embryo. There are many ethical and...

  • The influences of two different hemopoietic supporting stromal cells on the differentiation of hemopoietic cells from human embryonic stem cells. Huiping Zhao; Haijun Zhao; Ge Lin; Bin Luo; Le Tang; Di Zhou; Tiancheng Liu; Guang-Xiu Lu // Cell Research;Aug2008 Supplement, Vol. 18, pS122 

    To observe the inductive efficiency of deriving hematopoietic cells from human embryonic stem (hES) cells cocultured with human fetal liver stromal cells or fetal bone marrow stromal cells. In order to investigate the mechanism of the different inductive efficiency of the two stromal cells, 2-DE...

  • Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Luis, T C; Ichii, M; Brugman, M H; Kincade, P; Staal, F J T // Leukemia (08876924);Mar2012, Vol. 26 Issue 3, p414 

    A strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is required in order to maintain homeostasis, as well as to efficiently respond to injury and infections. Numbers and fate decisions made by progenitors derived from HSC must also be carefully regulated...

  • Peripheral Blood Stem Cells: Phenotypic Diversity and Potential Clinical Applications. Zhang, Yichi; Huang, Bing // Stem Cell Reviews & Reports;Sep2012, Vol. 8 Issue 3, p917 

    A small proportion of cells in peripheral blood are actually pluripotent stem cells. These peripheral blood stem cells (PBSCs) are thought to be heterogeneous and could be exploited for a variety of clinical applications. The exact number of distinct populations is unknown. It is likely that...

  • Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Wei Guo; Lasky, Joseph L.; Chun-Ju Chang; Mosessian, Sherly; Xiaoman Lewis; Yun Xiao; Yeh, Jennifer E.; Chen, James Y.; Iruela-Arispe, M. Luisa; Varella-Garcia, Marileila; Hong Wu // Nature;5/22/2008, Vol. 453 Issue 7194, p529 

    Cancer stem cells, which share many common properties and regulatory machineries with normal stem cells, have recently been proposed to be responsible for tumorigenesis and to contribute to cancer resistance. The main challenges in cancer biology are to identify cancer stem cells and to define...

  • Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century. Stoltz, J.-F.; de Isla, N.; Li, Y. P.; Bensoussan, D.; Zhang, L.; Huselstein, C.; Chen, Y.; Decot, V.; Magdalou, J.; Li, N.; Reppel, L.; He, Y. // Stem Cells International;8/2/2015, Vol. 2015, p1 

    Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics