TITLE

Human Infant Respiratory Syncytial Virus (RSV)--Specific Type 1 and 2 Cytokine Responses Ex Vivo during Primary RSV Infection

AUTHOR(S)
Lee, F. Eun-Hyung; Walsh, Edward E.; Falsey, Ann R.; Lumb, Megan E.; Okam, Ngozi V.; Nathaniel Liu; Divekar, Anagha A.; Hall, Caroline B.; Mosmann, Tim R.
PUB. DATE
June 2007
SOURCE
Journal of Infectious Diseases;6/15/2007, Vol. 195 Issue 12, p1779
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Respiratory syncytial virus (RSV) infection is the most common respiratory viral infection resulting in hospitalizations in infants worldwide. Illness severity is likely multifactorial; however, unlike other viral infections, both type 1 and type 2 cytokine responses have been implicated in severe disease. Methods. We measured RSV-specific cytokine responses ex vivo during primary RSV infection in the blood of 18 infants with polymerase chain reaction-confirmed RSV infection. To focus on primary RSV infection, subjects were all < 9 months old. RSV-specific cytokine responses were measured at 3 time points during acute primary RSV infection and at 1 memory time point 3-6 months later. Results. RSV-specific interferon (IFN)-γ responses were detected in 10 of 18 of infants. Infants with mild disease had higher RSV-specific IFN-γ memory responses than did those with moderate or severe disease. No consistent correlations between RSV-specific IFN-γ responses and corticosteroid administration were observed. RSV-specific interleukin (IL)-4 or IL-5 responses to primary RSV infection were detectable in 5 of 18 and 8 of 15 infants, respectively. Conclusions. During primary RSV infection, many infants demonstrated RSV-specific IFN-γ responses. The strongest IL-4 and IL-5 responses were detected in 3 infants with severe disease, suggesting that type 2 responses may contribute to the pathogenesis of severe disease.
ACCESSION #
25095416

 

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