TITLE

Strain Prevalence, Rather than Innate Virulence Potential, Is the Major Factor Responsible for an Increase in Serious Group A Streptococcus Infections

AUTHOR(S)
Rogers, Susan; Commons, Robert; Danchin, Margaret H.; Selvaraj, Gowri; Kelpie, Loraine; Curtis, Nigel; Robins-Browne, Roy; Carapetis, Jonathan R.
PUB. DATE
June 2007
SOURCE
Journal of Infectious Diseases;6/1/2007, Vol. 195 Issue 11, p1626
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. It is postulated that the surge in incidence and severity of group A streptococcus (GAS) infections since the 1980s is due to the emergence of strains of GAS with increased virulence. We used active, population-based surveillance of invasive GAS disease, serologically confirmed pharyngitis, and carriage to determine whether particular strains were associated with invasive disease. Methods. Two hundred twenty GAS isolates were collected—78 invasive, 34 pharyngitis, and 108 carriage. Isolates were characterized using emm typing, random amplification of polymorphic DNA (RAPD) profiling, and superantigen genotyping. Results. emm1, emm12, and emm28 predominated in invasive disease and accounted for 30.8%, 12.8%, and 12.8% of all isolates, respectively. emm1, emm75, emm28, and emm4 were the most frequently isolated emm types in pharyngitis, and emm12 and emm1 predominated in carriage. emm12 was significantly associated with carriage rather than disease. There were no other significant associations between emm type and disease or carriage. There were no associations between any RAPD profile or superantigen genotype and invasive disease, pharyngitis, or carriage. One RAPD profile accounted for most cases of necrotizing fasciitis, which suggests that this strain might have particular features promoting connective-tissue infection. Conclusions. These data suggest that the emergence of GAS strains with increased virulence is not the main factor responsible for the surge in GAS-related infections. The prevalence of particular emm types, RAPD profiles, or superantigen genes in invasive disease may simply indicate widespread transmission of these strains in the population, rather than a particular ability to cause disease.
ACCESSION #
25095391

 

Related Articles

  • NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates. Tatsuno, Ichiro; Isaka, Masanori; Minami, Masaaki; Hasegawa, Tadao // BMC Microbiology;2010, Vol. 10, p144 

    Background: NAD-glycohydrolase (NADase) secreted by M-1 group A streptococcal (GAS) isolates are suspected as one of the virulence factors to cause severe invasive disease including streptococcal toxic shock-like syndrome (STSS). M-1 GAS strains were divided into three groups based on NADase...

  • Streptococcus moves inward. Cleary, P. Patrick // Nature Medicine;Apr2006, Vol. 12 Issue 4, p384 

    The article reports on the study which found that the wide spectrum of group A streptococcal (GAS) disease spans uncomplicated strep throat to flesh-eating would infections. According to the study, complications of GAS infections such as scarlet fever, rheumatic fever and acute...

  • Streptococcal pharyngitis. Alper, Brian S.; Fox, Gary N. // Cortlandt Forum;9/25/2004, Vol. 17 Issue 9, p76 

    Focuses on streptococcal pharyngitis. Other names; Prevalence; ICD-9 codes; Etiology; Patient history; Physical findings; Diagnosis; Testing; Prognosis; Complications; Treatment overview; Antibiotic regimens; Treatment of recurrent strep throat.

  • Molecular characteristics of pharyngeal and invasive emm3 Streptococcus pyogenes strains from Norway, 1988–2003. Meisal, R.; Høiby, E.; Caugant, D.; Musser, J. // European Journal of Clinical Microbiology & Infectious Diseases;Jan2010, Vol. 29 Issue 1, p31 

    A major virulence factor of group A streptococci (GAS) is the M protein. Strains with the M3 type are more often associated with necrotizing fasciitis (NF) and streptococcal toxic shock syndrome, and have a higher case fatality rate than strains of other M types. To better understand the...

  • Incompetence of Neutrophils to Invasive Group A streptococcus Is Attributed to Induction of Plural Virulence Factors by Dysfunction of a Regulator. Ato, Manabu; Ikebe, Tadayoshi; Kawabata, Hiroki; Takemori, Toshitada; Watanabe, Haruo // PLoS ONE;2008, Vol. 3 Issue 10, p1 

    Group A streptococcus (GAS) causes variety of diseases ranging from common pharyngitis to life-threatening severe invasive diseases, including necrotizing fasciitis and streptococcal toxic shock-like syndrome. The characteristic of invasive GAS infections has been thought to attribute to genetic...

  • Maternal β-hemolytic streptococcal pharyngeal exposure and colonization in pregnancy. Heidari-Bateni, Giv; Brar, Anoop K.; Hall, Matthew; Hathcock, Trupti; Epstein, Deirdre; Goessling, Lisa S.; Cunningham, Madeleine W.; Eghtesady, Pirooz // Infectious Diseases in Obstetrics & Gynecology;2014, p1 

    Objectives: To report the pharyngeal colonization rate of β-hemolytic streptococci and changes in the value of antistreptolysin O (ASO) and anti-DNase B serology titers during pregnancy.Methods: Healthy pregnant women were recruited and blood was drawn in each...

  • Acute glomerulonephritis in three siblings and suspectedemm49-typeStreptococcus pyogenesinfection. Motoyama, Osamu; Hasegawa, Kei; Okamatsu, Chizuko; Tamaki, Kazutomo; Iitaka, Kikuo // Clinical & Experimental Nephrology;Dec2004, Vol. 8 Issue 4, p356 

    Three siblings with poststreptococcal acute glomerulonephritis are presented. Streptococcal infection, impetigo, and pharyngitis preceded the acute glomerulonephritis. In one patient,emm49-typeStreptococcus pyogeneswas isolated, a strain which has not been reported as nephritogenic in Japan.

  • Selective testing strategies for diagnosing group A streptococcal infection in children with pharyngitis: a systematic review and prospective multicentre external validation study. Cohen, Jérémie F.; Cohen, Robert; Levy, Corinne; Thollot, Franck; Benani, Mohamed; Bidet, Philippe; Chalumeau, Martin // CMAJ: Canadian Medical Association Journal;1/6/2015, Vol. 187 Issue 1, p23 

    Background: Several clinical prediction rules for diagnosing group A streptococcal infection in children with pharyngitis are available. We aimed to compare the diagnostic accuracy of rules-based selective testing strategies in a prospective cohort of children with pharyngitis. Methods: We...

  • What is the most effective diagnostic evaluation of streptococcal pharyngitis? Merrill, Barth; Kelsberg, Gary; Jankowski, Terry Ann // Journal of Family Practice;Sep2004, Vol. 53 Issue 9, p734 

    This article discusses the most effective method for diagnosing streptococcal pharyngitis. Standardized clinical decision rules, such as the Centor criteria, can identify patients with low likelihood of group A beta-hemolytic streptococcal (GABHS) pharyngitis who require no further evaluation or...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics