TITLE

Effect of ethanol on the thermal stability of human serum albumin

AUTHOR(S)
Michnik, Anna; Drzazga, Zofia
PUB. DATE
May 2007
SOURCE
Journal of Thermal Analysis & Calorimetry;May2007, Vol. 88 Issue 2, p449
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effect of ethanol on human serum albumin stability in aqueous solution was studied by use of differential scanning calorimetry. A deconvolution of DSC traces in 2-state model with Δ C p=0 and Δ C p≠0 was performed and analysed to obtain information on the interaction of ethanol with different parts of albumin molecule both fatty acid containing and fatty acid free. The differences in ethanol binding affinity for both kinds of albumin were found. At very low concentrations ethanol was observed to be a stabilizer of the folded state of albumin contrary to the higher concentration where its binding to the unfolded protein predominates.
ACCESSION #
25043563

 

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