Heteropolymer translocation through nanopores

Kaifu Luo; Ala-Nissila, Tapio; See-Chen Ying; Bhattacharya, Aniket
April 2007
Journal of Chemical Physics;4/14/2007, Vol. 126 Issue 14, p145101
Academic Journal
The authors investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, they consider heteropolymers consisting of two types of monomers labeled A and B, which are distinguished by the magnitude of the driving force that they experience inside the pore. From a series of studies on polymers with sequences AmBn the authors identify both universal as well as specific sequence properties of the translocating chains. They find that the scaling of the average translocation time as a function of the chain length N remains unaffected by the heterogeneity, while the residence time of each bead is a strong function of the sequence for short repeat units. They further discover that for a symmetric heteropolymer AnBn of fixed length, the pattern exhibited by the residence times of the individual monomers has striking similarity with a double slit interference pattern where the total number of repeat units N/2n controls the number of interference fringes. These results are relevant for designing nanopore based sequencing techniques.


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