TITLE

Experimental Infection with Haemophilus ducreyi in Persons Who Are Infected with HIV Does Not Cause Local or Augment Systemic Viral Replication

AUTHOR(S)
Janowicz, Diane M.; Tenner-Racz, Klara; Racz, Paul; Humphreys, Tricia L.; Schnizlein-Bick, Carol; Fortney, Kate R.; Zwickl, Beth; Katz, Barry P.; Campbell, James J.; Ho, David D.; Spinola, Stanley M.
PUB. DATE
May 2007
SOURCE
Journal of Infectious Diseases;5/15/2007, Vol. 195 Issue 10, p1443
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We infected 11 HIV-seropositive volunteers whose CD4+ cell counts were >350 cells/μL (7 of whom were receiving antiretrovirals) with Haemophilus ducreyi. The papule and pustule formation rates were similar to those observed in HIV-seronegative historical control subjects. No subject experienced a sustained change in CD4+ cell count or HIV RNA level. The cellular infiltrate in biopsy samples obtained from the HIV-seropositive and HIV-seronegative subjects did not differ with respect to the percentage of leukocytes, neutrophils, macrophages, or T cells. The CD4+:CD8+ cell ratio in biopsy samples from the HIV-seropositive subjects was 1: 3, the inverse of the ratio seen in the HIV-seronegative subjects (P < .0001). Although CD4+ cells proliferated in lesions, in situ hybridization and reverse-transcription polymerase chain reaction for HIV RNA was negative. We conclude that experimental infection in HIV-seropositive persons is clinically similar to infection in HIV-seronegative persons and does not cause local or augment systemic viral replication. Thus, prompt treatment of chancroid may abrogate increases in viral replication associated with natural disease.
ACCESSION #
25029474

 

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