TITLE

Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma

AUTHOR(S)
Feltis, B. N.; Wignarajah, D.; Reid, D. W.; Ward, C.; Harding, R.; Walters, E. H.
PUB. DATE
April 2007
SOURCE
Thorax;Apr2007, Vol. 62 Issue 4, p314
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Subepithelial hypervascularity and angiogenesis in the airways are part of structural remodelling of the airway wall in asthma, but the effects of inhaled corticosteroids (ICS) on these have not been explored. Increased vascularity in asthma may contribute to a number of functional abnormalities. A study was undertaken to explore angiogenic modulation by ICS and its likely regulation via vascular endothelial growth factor (VEGF), its receptors and the angiopoietins. Methods: A placebo-controlled intervention study with ICS in asthma was performed, examining vascularity, VEGF, its receptors (VEGFR1 and VEGFR2), and angiopoietin-1 (Ang1) to assess which of these factors were changed in the asthmatic airways after ICS treatment. Airway wall biopsy specimens, lavage fluid and cells were obtained from 35 patients with mild asthma randomised to receive ICS or placebo for 3 months, after which bronchoscopic examination and sample collection were repeated. Immunohistochemistry and image analysis were used to obtain quantitative measures of vessels, angiogenic sprouts, VEGF, VEGFR1, VEGFR2 and Ang1 staining in airway biopsy specimens. ELISA was used to assess VEGF concentrations in the lavage fluid. Results: Vessel, VEGF and sprout staining were decreased after 3 months of ICS treatment. VEGF levels remained unchanged. VEGF receptors and Ang1 staining were not reduced after treatment. Conclusions: The findings of this study support an effect of ICS in downregulating angiogenic remodelling in the airways in asthma, associated with decreasing VEGF activity within the airway wall. The environment of the airways after treatment with ICS, with changes in the balance between VEGF, its receptors, Ang1 and sprouts, appears to be less angiogenic than in untreated asthma.
ACCESSION #
25021015

 

Related Articles

  • Significance of heparanase-1 and vascular endothelial growth factor in adrenocortical carcinoma angiogenesis: potential for therapy. Xu, Yun-ze; Zhu, Yu; Shen, Zhou-jun; Sheng, Jia-yan; He, Hong-chao; Ma, Gui; Qi, Yi-cheng; Zhao, Ju-ping; Wu, Yu-xuan; Rui, Wen-bin; Wei, Qing; Zhou, Wen-long; Xie, Xin; Ning, Guang // Endocrine (1355008X);Dec2011, Vol. 40 Issue 3, p445 

    The purpose of this study was to determine the correlation between human adrenocortical carcinoma (ACC) and the proteins involved in tumor angiogenesis, and to evaluate the angiogenic status of ACC. The expression of heparanase-1 (HPA-1), vascular endothelial growth factor (VEGF), and vascular...

  • VEGF signaling pathway inhibitors and hypertension: A review for oncologists. Michaud, Laura Boehnke // Hem/Onc Today;5/25/2010, Vol. 11 Issue 10, p71 

    The article evaluates the performance of vascular endothelial growth factor (VEGF) signalling pathway inhibitors in the angiogenesis process.

  • Anti-VEGF Therapy to Treat Corneal Neovascularization. Papathanassiou, M.; Theodoropoulou, S.; Analitis, S.; Tzonou, A. // Review of Ophthalmology;Jun2013, Vol. 20 Issue 6, p77 

    The article discusses the role of anti-vascular endothelial growth factor (VEGF) therapy in treatment of corneal neovascularization.

  • Anti-angiogenic role of Ankaferd on chick chorioallontoic membrane model. GÜLŞEN, Mert Ruşen; UZUNAY, Nur Sena; FERMANLI, Orhan; ÖZTÜRK, Duygu; ÇOBAN, Zehra Dilşad; GÜRAN, Şefik; HAMİDİ, Maiwand; AVCU, Ferit // Gulhane Medical Journal;eyl2015, Vol. 57 Issue 3, p274 

    Angiogenesis is needed for tumor growth and metastasis. For this reason, it represents an exciting target for cancer treatment. Some anti-angiogenic drugs may be useful to prevent angiogenesis during cancer treatment. The aim of this study is to investigate if Ankaferd (standardized herbal...

  • The era of anti-vascular endothelial growth factor (VEGF) drugs in ophthalmology, VEGF and anti-VEGF therapy. POżAROWSKA, DOROTA; POŻAROWSKI, PIOTR // Central European Journal of Immunology;2016, Vol. 41 Issue 3, p311 

    Angiogenesis is a clue process for tissue development and function, both in normal and pathological conditions. This process is regulated by multiple molecular systems. One of the most potent is vascular endothelial growth factor (VEGF) and its receptor (VEGFR) system. Members of this family are...

  • Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD. Chetta, Alfredo; Olivieri, Dario // International Journal of Endocrinology;2012, p1 

    In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli. Vascular changes may significantly contribute to airway wall remodelling. Angiogenesis and vascular...

  • Evaluation of angiopoietin 1 and 2, vascular endothelial growth factor, and tumor necrosis factor alpha levels in asthmatic children. Köksal, Burcu Tahire; Ozbek, Ozlem Yilmaz; Bayraktar, Nilufer; Yazici, Ayse Canan // Allergy & Asthma Proceedings;Nov/Dec2014, Vol. 35 Issue 6, p482 

    Asthma is characterized by chronic airway inflammation that is associated with structural changes termed airway remodeling. Recently, cytokines/mediators that augment inflammation have been attracting attention in this field. The aim of this study was to evaluate serum angiopoietin (Ang)-1,...

  • Rola wybranych cytokin i protein, badanych w popÅ‚uczynach oskrzelowo-pÄ™cherzykowych, w uszkodzeniu pÅ‚uc. Jedynak, Monika; Bobik, Piotr; Siemiątkowski, Andrzej // Advances in Hygiene & Experimental Medicine / Postepy Higieny i ;2014, Vol. 68, p728 

    The early organism response to injury or infection involves activation of the innate immune system, in which pattern recognition receptors (PRRs) participate. They recognize highly conservative structures that are called pathogen-associated molecular patterns (PAMPs) and damage-associated...

  • TIMP-1 in asthma: guilty by association. Johnson, S. R. // Thorax;Aug2005, Vol. 60 Issue 8, p617 

    Focuses on the role of matrix metalloproteinases (MMP) in asthma. Release and activation of growth and angiogenic factors including trasforming growth factor and vascular endothelial growth factor; Contribution of MMPs to altered matrix turnover, epithelial repair and angiogenesis; Association...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics