TITLE

Living at high altitude and risk of hospitalisation for atopic asthma in children: results from a large prospective birth-cohort study

AUTHOR(S)
Kiechl-Kohlendorfer, U.; Horak, E.; Mueller, W.; Strobl, R.; Haberland, C.; Fink, F. M.; Schwaiger, M.; Gutenberger, K. H.; Reich, H.; Meraner, D.; Kiechl, S.
PUB. DATE
April 2007
SOURCE
Archives of Disease in Childhood;Apr2007, Vol. 92 Issue 4, p339
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Asthma is among the most common chronic diseases in childhood and is steadily increasing in prevalence. Better characterisation of factors that determine the risk of hospitalisation for atopic asthma in childhood may help design prevention programmes and improve our understanding of disease pathobiology. This study will focus on the altitude of residence. Methods: This is an ongoing prospective birth-cohort study that enrolled all live-born infants in the Tyrol. Between 1994 and 1999, baseline data were collected for 33 808 infants. From 2000 to 2005, all children hospitalised for atopic asthma at the age of ⩾6 years (n = 305) were identified by a careful search of hospital databases. Disease status was ascertained from the typical medical history, a thorough examination and proof of atopy. Results: Living at higher altitude was associated with an enhanced risk of hospitalisation for atopic asthma (multivariate RRs (95% confidence interval 2.08 (1.45 to 2.98) and 1.49 (1.05 to 2.11) for a comparison between altitude categories ⩾1200 m and 900–1199m versus <900 m; p<0.001). This finding applied equally to hospital admissions in spring, summer, autumn and winter. When altitude of residence was analysed as a continuous variable, the risk for asthma hospitalisation increased by 7% for each 100-m increase in altitude (p=0.013). Conclusions: This large prospective study shows a significant association between the risk of hospitalisation for atopic asthma and altitude of residence between 450 and 1800 m. The underlying mechanisms remain to be elucidated, but it is tempting to speculate about a role for altitude characteristics such as the decline in outdoor temperature and air humidity and increase in ozone levels, which may trigger airway hyper-responsiveness and attenuate lung function.
ACCESSION #
25020987

 

Related Articles

  • The early origins of COPD in severe asthma: the one thing that leads to another or the two things that come together? Mattes, Joerg; Gibson, Peter G. // Thorax;Sep2014, Vol. 69 Issue 9, p789 

    The authors reflect on the early origins of chronic obstructive pulmonary disease (COPD) in severe asthma, focusing on the study by Tai and colleagues on the association between childhood asthma and adult COPD. They mention children with severe asthma were at increased risk of developing adult...

  • Independent Nurse: Asthma - Asthma attack risk factors identified.  // GP: General Practitioner;11/4/2005, p83 

    The article reports that Dutch researchers have identified five risk factors that could predict which asthmatic patients are likely to suffer severe attacks needing hospitalization. The scientists studied 136 patients with difficult-to-treat asthma. Patients with more than three severe...

  • Chronic virus infections supress atopy but not asthma in a set of children from a large latin american city: a cross-section study. Veiga, Rafael V.; Cunha, Sergio S.; Dattoli, Vitor C. C.; Cruz, Álvaro C.; Cooper, Phillip J.; Rodrigues, Laura C.; Barreto, Maurício L.; Alcantara-Neves, Neuza M. // BMC Pulmonary Medicine;2011, Vol. 11 Issue 1, p24 

    Background: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increased exposure to infections may provide protection against the development...

  • Highlights from this issue. Bush, Andrew; Pavord, Ian // Thorax;Sep2014, Vol. 69 Issue 9, pi 

    An introduction is presented in which the editors discuss various reports within the issue on topics including the diagnosis of asthma in children and the increased risk of developing obstructive lung diseases (COPD), the use of non-invasive ventilation (NIV) to treat COPD patients, and the...

  • Prevalence and Risk Factors for Childhood Asthma in Zonguldak, Turkey. Tomac, Nazan; Demirel, Fatma; Acun, Ceyda; Ayoglu, Ferruh // Allergy & Asthma Proceedings;Sep/Oct2005, Vol. 26 Issue 5, p397 

    Prevalence of asthma and other allergic diseases varies between different regions throughout the world The aim of this study was to determine the prevalence of asthma and allergies and some risk factors for asthma in schoolchildren, aged between 6 and 16 years old, in Zonguldak, Turkey. We...

  • ARCHIVIST: Acute stress and asthma.  // Archives of Disease in Childhood;Jun2005, Vol. 90 Issue 6, p588 

    The article presents information about acute stress and asthma in children. A study in Glasgow by researcher S. Sandberg and colleagues revealed among children with asthma a severely stressful life event increased the risk of an acute exacerbation 3-6 weeks after the event. High levels of...

  • Association between Asthma Severity and Body Mass Index in Pediatric Allergy Clinic in Mashhad. Behmanesh, Fatemeh; Daluee, Mohammad Khaje; Mohajerzadeh, Mina Sadat // Macedonian Journal of Medical Sciences;6/1/2010, Vol. 3 Issue 2, p149 

    Introduction: Increase in the prevalence of obesity and asthma over recent decades has been reported in the literature. Various studies have shown a correlation between increased body mass index (BMI) and asthma prevalence. Objective: The aim of this study was to determine whether there is a...

  • The association between childhood asthma and adult chronic obstructive pulmonary disease. Tai, Andrew; Tran, Haily; Roberts, Mary; Clarke, Nadeene; Wilson, John; Robertson, Colin F. // Thorax;Sep2014, Vol. 69 Issue 9, p805 

    Introduction There is epidemiological evidence to suggest that events in childhood influence lung growth and constitute a significant risk for adult COPD. The aim of the study is to evaluate for an association between childhood asthma and adult COPD. Methods This longitudinal, prospective study...

  • Prediction and treatment of asthma in preschool children at risk: study design and baseline data of a prospective cohort study in general practice (ARCADE). Van Wonderen, Karina E.; Van der Mark, Lonneke B.; Mohrs, Jacob; Geskus, Ronald B.; Van der Wal, Willem M.; Van Aalderen, Wim M. C.; Bindels, Patrick J. E.; Riet, Gerben ter // BMC Pulmonary Medicine;2009, Vol. 9, Special section p1 

    Background: Asthma is a difficult diagnosis to establish in preschool children. A few years ago, our group presented a prediction rule for young children at risk for asthma in general practice. Before this prediction rule can safely be used in practice, cross-validation is required. In addition,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics