C-reactive protein is elevated in the offspring of parents with essential hypertension

Díaz, Juan Jose; Arguelles, Juan; Málaga, Ignacio; Perillán, Carmen; Diéguez, Angeles; Vijande, Manuel; Málaga, Serafín
April 2007
Archives of Disease in Childhood;Apr2007, Vol. 92 Issue 4, p304
Academic Journal
Background: Hypertension is a risk factor for cardiovascular disease (CVD). Studies in adults have shown that high sensitivity C-reactive protein (CRP) levels are associated with increased risk of CVD and essential hypertension (EHT). Genetic background is widely accepted as a risk factor for CVD. The aim of the present study was to analyse the association of high sensitivity CRP levels with other cardiovascular risk factors in children and young adults with at least one parent with EHT. Methods: Fifty one healthy children and young adults (28 boys) with at least one parent with hypertension and 69 (41 boys) whose parents did not have hypertension were recruited prospectively from primary care centres. High sensitivity CRP, fasting lipid profile, blood pressure (BP) and anthropometric variables were obtained far all participants. Results: CRP values were higher in the study group than in controls (logCRP mean difference: -0.69; 95% confidence interval: -1.05 to -0.33), even when differences were adjusted for age, gender, body mass index (BMI) and triglyceride levels (p = 0.01). No differences were observed in BP values between groups. In the study group, 35.3% of the participants had a CRP level ⩾1 mg/l compared to 14.5% in the control group (p=0.009). CRP showed a significant correlation with body weight (rho=0.28, p=0.04), BMI (rho=0.32; p=0.02) and ponderosity index (rho=0.28; p<0.05). Conclusions: CRP is significantly higher in the offspring of parents with EHT. A significant positive relationship exists between BMI and serum CRP levels in this high risk group of children and young adults.


Related Articles

  • C-reactive protein and Hypertension. Hage, F G // Journal of Human Hypertension;Jul2014, Vol. 28 Issue 7, p410 

    C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate...

  • C-reactive Protein Identified as Risk Factor for Hypertension.  // Nutrition Health Review: The Consumer's Medical Journal;2006, Issue 96, p8 

    The article reports on the direct role of C-reactive protein in the onset of hypertension. The relationship was discovered by researchers at the University of Southwestern Medical Center in Dallas, Texas. CRP is not only a marker of risk of hypertension but actually induces hypertension. High...

  • CRP and HTN treatment.  // Clinical Cardiology Alert;Nov2009 Clinical Briefs, p22 

    The article discusses research on the link between levels of c-reactive protein (CRP) and treatment of hypertension (HTN). It references the study by T. Fulop et al published in a 2009 issue of the "Journal of the American Society of Hypertension." It found that the main method of reducing risk...

  • CRP and HTN treatment.  // Clinical Oncology Alert;Nov2009 Supplement, p22 

    The article discusses research on the link between levels of c-reactive protein (CRP) and treatment of hypertension (HTN). It references the study by T. Fulop et al published in a 2009 issue of the "Journal of the American Society of Hypertension." It found that the main method of reducing risk...

  • Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation. Dubowsky, Sara D.; Suh, Helen; Schwartz, Joel; Coull, Brent A.; Gold, Diane R. // Environmental Health Perspectives;Jul2006, Vol. 114 Issue 7, p992 

    Airborne particulate matter (PM) may lead to increased cardiac risk through an inflammatory pathway. Therefore, we investigated associations between ambient PM and markers of systemic inflammation among repeated measures from 44 senior citizens (≥ 60 years of age) and examined...

  • Limited clinical utility of high-sensitivity plasma C-reactive protein assays. Campbell, Bruce; Badrick, Tony; Flatman, Robert; Kanowski, David // Annals of Clinical Biochemistry;Mar2002, Vol. 39 Issue 2, p85 

    Many recent studies have shown a relationship between plasma C-reactive protein (CRP) concentrations and risk of cardiovascular disease. However, the intra-individual variation in plasma CRP concentrations is large. Use of plasma CRP measurement in individual patients is likely to result in many...

  • High-Sensitivity C-Reactive Protein Is Not Independently Associated With Peripheral Subclinical Atherosclerosis. Bo, Mario; Corsinovi, Laura; Brescianini, Alessia; Sona, Alessandro; Astengo, Marco; Dumitrache, Raluca; Ferrio, Maria Federica; Pricop, Larisa; Fonte, Gianfranco // Angiology;Feb/Mar2009, Vol. 60 Issue 1, p12 

    Objective. This study investigated whether high-sensitivity C-reactive protein (hs-CRP) levels are independently associated with subclinical peripheral atherosclerosis. Methods. Clinical variables, cardiovascular (CV) risk factors, 10-year CV risk, the ankle-brachial Index (ABI), and the carotid...

  • NEW BLOOD TEST TO PREDICT STROKE RISK.  // Wellness Options;2005, Issue 21, p10 

    Reports on the results of the Atherosclerosis Risk in Communities study which found out that a blood test can predict stroke risk. Limitation of using C-reactive protein as a marker of inflammation; Indication of an elevation of an inflammatory enzyme bound to low density lipoproteins.

  • High sensitivity C-reactive protein and cardiovascular disease: an association built on unstable foundations? Sattar, Naveed; Lowe, Gordon D // Annals of Clinical Biochemistry;Jul2006, Vol. 43 Issue 4, p252 

    There is considerable interest in the inflammatory hypothesis of vascular disease. Markers of inflammation predict vascular events, and inflammatory cells and molecules are critical elements within plaques and are especially prominent in unstable lesions. With respect to screening,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics