Turning up the Power: High Intensity Focused Ultrasound (HIFU) for the Treatment of Cancer

ter Haar, Gail
May 2007
Ultrasound;2007, Vol. 15 Issue 2, p73
Academic Journal
Diagnostic ultrasound is generally considered to provide images without causing any significant biological effects in the tissues being visualized. If, however, the energy used is increased sufficiently, ultrasound can kill cells instantaneously, and causes thermal necrosis. High intensity focused ultrasound beams are being used to destroy masses in deep-seated tissues without damage to the intervening, overlying structures. This new technique is being investigated for use in the treatment of cancer of the prostate, liver, kidney, breast and bone.


Related Articles

  • Development of a 3D patient-specific planning platform for interstitial and transurethral ultrasound thermal therapy. Prakash, Punit; Diederich, Chris J. // AIP Conference Proceedings;3/9/2010, Vol. 1215 Issue 1, p396 

    Interstitial and transurethral catheter-based ultrasound devices are under development for treatment of prostate cancer and BPH, uterine fibroids, liver tumors and other soft tissue disease. Accurate 3D thermal modeling is essential for designing site-specific applicators, exploring treatment...

  • Ultrasound Strain Imaging Towards Verification and Guidance of Prostate Thermal Therapy with Catheter-Based Ultrasound Applicators. Sridhar-Keralapura, Mallika; Chubb, Nicole; Scott, Serena; Phipps, Natalie; Burdette, Clif; Diederich, Chris // AIP Conference Proceedings;3/9/2010, Vol. 1215 Issue 1, p337 

    Ultrasound based transurethral and interstitial catheters have been developed and tested in vivo to thermally ablate prostate cancers. Treatment validation and accurate control of therapy is currently done using MR thermal imaging (±1° C, update: 5–15 s). MRTI is effective for...

  • Intermediate and advanced hepatocellular carcinoma treated with the antiangiogenic agent sorafenib. Evaluation with unenhanced and contrast-enhanced ultrasonography. Moschouris, Hippocrates; Malagari, Katerina; Gkoutzios, Panagiotis; Kalokairinou, Marianna; Stamatiou, Konstantinos; Chatzimichail, Katerina; Kornezos, Ioannis; Karagiannis, Evagelos; Kiltenis, Michail; Papadaki, Marina Georgiou // Medical Ultrasonography;Jun2012, Vol. 14 Issue 2, p87 

    Aims: To evaluate the sonographic changes observed in hepatocellular carcinoma (HCC) post antiangiogenic treatment with sorafenib. Patients and methods: Twenty one intermediate or advanced HCC patients (19 men, 2 women; mean age: 66.8years; 32 target tumors-TTs) received sorafenib as monotherapy...

  • Animal and Clinical Studies for the Treatment of Liver Carcinomas with High-Intensity Focused Ultrasound (HIFU). Fukuda, Hiroyuki; Yamaguchi, Taketo; Yukisawa, Seigo; Masuya, Yoshio; Sudo, Kentaro; Okabe, Shinichiro; Yoshikawa, Masaharu; Ebara, Masaaki; Saisho, Hiromitsu; Ohto, Masao; Shinozuka, Norihiro; Li, Fagi; Zhu, Hui; Jin, Chengbin; Wu, Feng; Wang, Zhi-Biao // AIP Conference Proceedings;2007, Vol. 911 Issue 1, p375 

    In the study carried out in goats, we used the JC200 focused ultrasound tumor therapeutic system (Chongqing Haifu Tech Co., Ltd, China). The therapeutic ultrasound energy is produced by a transducer with a focal length of 160mm, at a frequency of 0.8MHz. The animals (n=6) were divided into a...

  • Update on Low Dose Rate Prostate Brachytherapy. Potters, Louis // AUANews;Dec2009, Vol. 14 Issue 12, p17 

    The article presents information on low dose rate prostate brachytherapy (PPB), a treatment option for prostate cancer. The procedure is performed on an outpatient basis by using real-time ultrasound guidance. Possible candidates for PPB are those patients with low and intermediate risk disease....

  • Fast Conformal Thermal Ablation in the Prostate with Transurethral Multi-Sectored Ultrasound Devices and MR Guidance. Kinsey, Adam M.; Diederich, Chris J.; Nau, William H.; Ross, Anthony B.; Pauly, Kim Butts; Rieke, Viola; Sommer, Graham // AIP Conference Proceedings;2007, Vol. 911 Issue 1, p400 

    Transurethral ultrasound applicators incorporating an array of multisectored tubular transducers were evaluated in theoretical simulations and in vivo canine prostates under MR guidance as a method for fast, conformal thermal therapy of the prostate. Comprehensive simulations with a biothermal...

  • Neoplastic Seeding After Radiofrequency Ablation for Hepatocellular Carcinoma. Imamura, Jun; Tateishi, Ryosuke; Shiina, Shuichiro; Goto, Eriko; Sato, Takahisa; Ohki, Takamasa; Masuzaki, Ryota; Goto, Tadashi; Yoshida, Hideo; Kanai, Fumihiko; Hamamura, Keisuke; Obi, Shuntaro; Yoshida, Haruhiko; Omata, Masao // American Journal of Gastroenterology;Dec2008, Vol. 103 Issue 12, p3057 

    BACKGROUND: Neoplastic seeding reportedly occurs in up to 12.5% of patients treated with radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). The aim of this study is to assess the incidence, risk factors, and prognosis of neoplastic seeding after RFA among a large number of...

  • Current role of ultrasound for the management of hepatocellular carcinoma. Maruyama, Hitoshi; Yoshikawa, Masahura; Yokosuka, Osamu; Karakose, Serdar; Romero-Gómez, Manuel // World Journal of Gastroenterology;3/21/2008, Vol. 14 Issue 11, p1710 

    Hepatocellular carcinoma (HCC) has a decisive influence on the prognosis of cirrhotic patients. Although α-fetoprotein (AFP) is a known and specific tumor maker for HCC, it is not suitable for the screening and surveillance of HCC because of its poor predictive value and low sensitivity. The...

  • Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis. XUE SUN; RU LI; BOTAO ZHANG; YUEJIE YANG; ZHIFEI CUI // Oncology Letters;Mar2016, Vol. 11 Issue 3, p2096 

    Liver cancer is a malignancy of the digestive system and has a high morbidity and mortality rate. Local intervention has become a viable option in identifying liver treatment. The aim of the present study was to analyze the clinical effects of treating liver cancer in middle and advanced stages...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics