TITLE

Abnormality of Gait as a Predictor of Non-Alzheimer's Dementia

AUTHOR(S)
Verghese, Joe; Lipton, Richard B.; Hall, Charles B.; Kuslansky, Gail; Katz, Mindy J.; Buschke, Herman
PUB. DATE
November 2002
SOURCE
New England Journal of Medicine;11/28/2002, Vol. 347 Issue 22, p1761
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Neurologic abnormalities affecting gait occur early in several types of non-Alzheimer's dementias, but their value in predicting the development of dementia is uncertain. Methods: We analyzed the relation between neurologic gait status at base line and the development of dementia in a prospective study involving 422 subjects older than 75 years of age who lived in the community and did not have dementia at base line. Cox proportional-hazards regression analysis was used to calculate hazard ratios with adjustment for potential confounding demographic, medical, and cognitive variables. Results: At enrollment, 85 subjects had neurologic gait abnormalities of the following types: unsteady gait (in 31 subjects), frontal gait (in 12 subjects), hemiparetic gait (in 11 subjects), neuropathic gait (in 11 subjects), ataxic gait (in 10 subjects), parkinsonian gait (in 8 subjects), and spastic gait (in 2 subjects). During follow-up (median duration, 6.6 years), there were 125 newly diagnosed cases of dementia, 70 of them cases of Alzheimer's disease and 55 cases of non-Alzheimer's dementia (47 of which involved vascular dementia and 8 of which involved other types of dementia). Subjects with neurologic gait abnormalities had a greater risk of development of dementia (hazard ratio, 1.96 [95 percent confidence interval, 1.30 to 2.96]). These subjects had an increased risk of non-Alzheimer's dementia (hazard ratio, 3.51 [95 percent confidence interval, 1.98 to 6.24]), but not of Alzheimer's dementia (hazard ratio, 1.07 [95 percent confidence interval, 0.57 to 2.02]). Of non-Alzheimer's dementias, abnormal gait predicted the development of vascular dementia (hazard ratio, 3.46 [95 percent confidence interval, 1.86 to 6.42]). Among the types of abnormal gait, unsteady gait predicted vascular dementia (hazard ratio, 2.61), as did frontal gait (hazard ratio, 4.32) and hemiparetic gait (hazard ratio, 13.13). Conclusions: The presence of neurologic gait abnormalities in elderly persons without dementia at base line is a significant predictor of the risk of development of dementia, especially non-Alzheimer's dementia. (N Engl J Med 2002;347:1761-8.)
ACCESSION #
24943008

 

Related Articles

  • Gait and Equilibrium in Subcortical Vascular Dementia. Moretti, Rita; Torre, Paola; Antonello, Rodolfo M.; Esposito, Francesca; Bellini, Giuseppe // Current Gerontology & Geratrics Research;2011, p1 

    Subcortical vascular dementia is a clinical entity, widespread, even challenging to diagnose and correctly treat. Patients with this diagnosis are old, frail, often with concomitant pathologies, and therefore, with many drugs in therapy. We tried to diagnose and follow up for three years more...

  • Acceleration Patterns of the Head and Pelvis When Walking Are Associated With Risk of Falling in Community-Dwelling Older People. Menz, Hylton B.; Lord, Stephen R.; Fitzpatrick, Richard C. // Journals of Gerontology Series A: Biological Sciences & Medical ;May2003, Vol. 58 Issue 5, p446 

    Examines whether older people at risk of falling demonstrate an impaired ability to stabilize the body under challenging conditions. List of gait analysis techniques; Axes used in the measurement of linear accelerations of the body; Differences in temporospatial gait parameters between falls...

  • Older women with dementia can perform fast alternating forearm movements and performance is correlated with tests of lower extremity function. Bramell-Risberg, Eva; Jarnlo, Gun-Britt; Elmståhl, Sölve // Clinical Interventions in Aging;2013, Vol. 8, p175 

    Background: The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia. Fast alternating movements was studied in 26 female patients (mean age...

  • A practical method for the detection of freezing of gait in patients with Parkinson's disease. Yuri Kwon; Sang Hoon Park; Ji-Won Kim; Yeji Ho; Hyeong-Min Jeon; Min-Jung Bang; Gu-In Jung; Seon-Min Lee; Gwang-Moon Eom; Seong-Beom Koh; Jeong-Whan Lee; Heung Seok Jeon // Clinical Interventions in Aging;2014, Vol. 9, p1709 

    Purpose: Freezing of gait (FOG), increasing the fall risk and limiting the quality of life, is common at the advanced stage of Parkinson's disease, typically in old ages. A simple and unobtrusive FOG detection system with a small calculation load would make a fast presentation of on-demand...

  • THE PATH TO LOCOMOTOR DISABILITY AMONG OLDER PEOPLE. Ayis, S.; Bowling, A.; Ebrahim, S. // Age & Ageing;May2004 Supplement 1, Vol. 33, pi20 

    Presents an abstract of the study "The Path to Locomotor Disability Among Older People," by S. Ayis, A. Bowling and S. Ebrahim.

  • A Smart Insole to Promote Healthy Aging for Frail Elderly Individuals: Specifications, Design, and Preliminary Results. Piau, Antoine; Charlon, Yoann; Campo, Eric; Vellas, Bruno; Nourhashemi, Fati // Journal of Medical Internet Research;May2015, Vol. 17 Issue 5, p1 

    Background: Older individuals frequently experience reversible "frailty syndrome,", increasing incidence of disability. Although physical exercise interventions may delay functional decline, there are difficulties in implementing them and performing seamless follow-up at home. Very few...

  • Multisystem Physiologic Impairments and Changes in Gait Speed of Older Adults. Rosso, Andrea L.; Sanders, Jason L.; Arnold, Alice M.; Boudreau, Robert M.; Hirsch, Calvin H.; Carlson, Michelle C.; Rosano, Caterina; Kritchevsky, Stephen B.; Newman, Anne B. // Journals of Gerontology Series A: Biological Sciences & Medical ;Mar2015, Vol. 70 Issue 3, p317 

    Background: Slowed gait is an important health indicator in older adults but a single identifiable cause is often lacking. We assessed whether a summary index measuring impairments across multiple physiologic systems was associated with slowed gait in older individuals. Methods: Data from the...

  • Spatiotemporal gait parameters during dual task walking in need of care elderly and young adults. Agner, S.; Bernet, J.; Brülhart, Y.; Radlinger, L.; Rogan, S. // Zeitschrift für Gerontologie und Geriatrie;Dec2015, Vol. 48 Issue 8, p740 

    Background: Up to now there have only been marginal data in the elderly in need of care regarding spatiotemporal gait parameters during single (ST) and dual tasking (DT). Aim: The aim of this study was to allocate data for gait speed, cadence and stride length cycle variability in the elderly in...

  • A water-based training program that include perturbation exercises to improve stepping responses in older adults: study protocol for a randomized controlled cross-over trial. Melzer, Itshak; Elbar, Ori; Tsedek, Irit; Oddsson, Lars I. E. // BMC Geriatrics;2008, Vol. 8, Special section p1 

    Background: Gait and balance impairments may increase the risk of falls, the leading cause of accidental death in the elderly population. Fall-related injuries constitute a serious public health problem associated with high costs for society as well as human suffering. A rapid step is the most...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics