Intrapleural Fibrinolytics Combined With Image-Guided Chest Tube Drainage for Pleural Infection

Levinson, Gary M.; Pennington, Daniel W.
April 2007
Mayo Clinic Proceedings;Apr2007, Vol. 82 Issue 4, p407
Academic Journal
OBJECTIVE: To present our method of treating pleural Infection by using a combination of image-guided chest tube drainage and Intrapleural fibrinolytics. PATIENTS AND METHODS: We retrospectively reviewed the medical charts and radiographs of 30 consecutive patients with pleural Infection who were seen at our institution from December 15, 1995, to July 1, 2006, 27 of whom received Intrapleural urokinase or tissue-type plasminogen activator. End points were death, length of stay In the hospital, and percentage of patients who needed surgery. RESULTS: Placement of chest tubes required image guidance 45.7% of the time. Three patients (10%; 95% confidence Interval, 2.1%–26.5%) died of complications from pleural infection. None of the 30 patients (0%; 95% confidence interval, 0%–9.5%) required surgery for treatment of pleural infection. The median hospital length of stay was 11 days. CONCLUSION: In the treatment of pleural infection, intrapleural urokinase or tissue-type plasminogen activator in combination with careful Image-guided placement of chest tubes is highly effective In resolving the effusion and curing the Infection.


Related Articles

  • Intrapleural Fibrinolytics for Pleural Infection: Partial Answers in the Discussion of Surgical vs Nonsurgical Treatment. Deschamps, Claude // Mayo Clinic Proceedings;Apr2007, Vol. 82 Issue 4, p405 

    The author reflects on the study "Intrapleural fibrinolytics combined with image-guided chest tube drainage for pleural infection," by G. M. Levinson and D. W. Pennington. He argues that critical information of their proposed treatment option for pleural infection is missing despite their claims...

  • Recombinant Human Endostatin Endostar Suppresses Angiogenesis and Lymphangiogenesis of Malignant Pleural Effusion in Mice. Xingqun Ma; Yanwen Yao; Dongmei Yuan; Hongbing Liu; Shouju Wang; Changsheng Zhou; Yong Song // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    Background: Malignant pleural effusion (MPE) is a common complication of lung cancer. One widely used treatment for MPE is Endostar, a recombined humanized endostatin based treatment. However, the mechanism of this treatment is still unclear. The aim of this study was to investigate the effects...

  • Diagnosis and Management of Parapneumonic Effusions and Empyema. Sahn, Steve A. // Clinical Infectious Diseases;12/1/2007, Vol. 45 Issue 11, p1480 

    Approximately 1 million patients develop parapneumonic effusions (PPEs) annually in the United States. The outcome of these effusions is related to the interval between the onset of clinical symptoms and presentation to the physician, comorbidities, and timely management. Early antibiotic...

  • pleurorrhea.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1807 

    A definition of the medical term "pleurorrhea," which refers to effusion of fluid into the pleura, is presented.

  • Pleural Effusion from Malignancy. Leff, Alan; Hopewell, Philip C.; Costello, John // Annals of Internal Medicine;Apr78, Vol. 88 Issue 4, p532 

    Provides information on pleural effusion from metastatic malignancy. Dynamics of pleural-fluid formation; Characteristics of malignant effusion; Diagnosis of metastatic pleural malignancy; Details on the methods of treatment of recurrent effusion; Conclusions and recommendations.

  • Unusual Cause of Bilateral Pleural Effusion. GOWRINATH, K.; JYOTHI, P.; RAGHAVENDRA, C. // Journal of Clinical & Diagnostic Research;Jun2015, Vol. 9 Issue 6, p2 

    An image showing unusual cause of bilateral pleural effusionin in a patient is presented.

  • Parapneumonic Effusion in Children. Hendaus, Mohamed A.; Janahi, Ibrahim A. // Clinical Pediatrics;Jan2016, Vol. 55 Issue 1, p10 

    In this article, the author recommends use of several measures including treatment with broad-spectrum antibiotics, intrapleural administration of fibrinolytics and video-assisted thoracic surgery in case of parapneumonic effusion (PPE) in children. It mentions increased incidence of...

  • New Developments in the Management of Pleural Effusions. RL Medford, Andrew; Maskell, Nick A. // Current Respiratory Medicine Reviews;2006, Vol. 2 Issue 3, p305 

    Pleural diseases are a commonly encountered problem by general physicians and chest specialists alike. Despite this, there has been a lack of research over the last few decades in this important field. This review focuses on new developments in the management of pleural effusions. We have...

  • Seldinger Approach Of Pleural Effusion Drainage In Emergency Department. Bertolaccini, Luca; Barberis, Luigi; Manno, Emilpaolo; Massaglia, Ferdinando // Internet Journal of Thoracic & Cardiovascular Surgery;2006, Vol. 8 Issue 1, p5 

    Previous articles confirmed high incidence of pleural effusions in Emergency Department. Aim of this prospective observational study was to avoid repeated thoracentesis and drain large effusions using an indwelling 16 G single lumen central venous catheter (CVC). 56 patients were studied...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics