N-Glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems

Balen, Biljana; Krsnik-Rasol, Marijana
January 2007
Food Technology & Biotechnology;Jan-Mar2007, Vol. 45 Issue 1, p1
Academic Journal
Transgenic plants have recently emerged as a promising system for low-cost and large-scale production of therapeutic proteins. Despite many advantages plants offer as hosts for expression of recombinant proteins, there are certain limitations caused by major structural differences between plant and mammalian N-linked glycans. Thus, efforts are being made in order to eliminate, or at least minimize, plant-specific N-glycosylation as well as to supplement the plant endogenous system with human glycosyltransferases to obtain «humanized» non-immunogenic N-glycans on plant-made pharmaceuticals aimed for human therapy.


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