Effect of Tilarginine Acetate in Patients With Acute Myocardial Infarction and Cardiogenic Shock

April 2007
JAMA: Journal of the American Medical Association;4/18/2007, Vol. 297 Issue 15, p1657
Academic Journal
The article presents a randomized controlled trial that examined the effects of the nitric oxide synthase inhibitor tilarginine acetate in patients with myocardial infarction and refractory cardiogenic shock. All patients in the study had an open infarct artery. Outcomes measured in the study included mortality from any cause, resolution and duration of shock, and the duration of mechanical ventilation and intra-aortic balloon pump support. The study found that tilarginine did not reduce mortality rates in patients with refractory cardiogenic shock and myocardial infarction.


Related Articles

  • Lack of Benefit From Nitric Oxide Synthase Inhibition in Patients With Cardiogenic Shock. Ndrepepa, Gjin; Schömig, Albert; Kastrati, Adnan // JAMA: Journal of the American Medical Association;4/18/2007, Vol. 297 Issue 15, p1711 

    The article presents an editorial that discusses a lack of benefit associated with the inhibition of nitric oxide synthase in patients with cardiogenic shock complicating acute myocardial infarction (MI). The results of a randomized controlled study, called the Tilarginine Acetate Injection in a...

  • Primary Percutaneous Coronary Intervention.  // Current Medical Literature: Cardiology;2007, Vol. 26 Issue 2, p56 

    The article presents editor's notes on research about primary percutaneous coronary intervention (PPCI). A prospective study by B. R. Brodie identifies cardiogenic shock in some patients who were enrolled in a registry and underwent PPCI between 1984 and 2004. Another research by P. X. Adams...

  • Mechanical circulatory support in cardiogenic shock - what every interventional cardiologist should know. Pyka, Łukasz; Pres, Damian; Przybylski, Roman; Pacholewicz, Jerzy; Poloński, Lech; Zembala, Marian; Gąsior, Mariusz // Advances in Interventional Cardiology;2014, Vol. 10 Issue 3, p195 

    Cardiogenic shock (CS) remains the main cause of death in patients with myocardial infarction. Conservative treatment alone does not sufficiently improve prognosis. Mortality in CS can only be significantly reduced with revascularization, both surgical and percutaneous. However some patients...

  • Association of Khat Chewing With Increased Risk of Stroke and Death in Patients Presenting With Acute Coronary Syndrome. Ali, Waleed M.; Zubaid, Mohammad; Al-Motarreb, Ahmed; Singh, Rajivir; Al-Shereiqi, Sulaiman Z.; Shehab, Abdulah; Rashed, Wafa; Al-Sagheer, Norah Q.; Saleh, Abdo H.; Al Suwaidi, Jassim // Mayo Clinic Proceedings;Nov2010, Vol. 85 Issue 11, p974 

    OBJECTIVE: To evaluate the prevalence and significance of khat chewing In patients with acute coronary syndrome (ACS). PATIENTS AND METHODS: From January 29,2007, through July 29, 2007, 8176 consecutive patients presenting with ACS were enrolled in a prospective, multicenter study from 6...

  • A Clinical Trial of the Angiotensin-Converting—Enzyme Inhibitor Trandolapril in Patients with Left Ventricular Dysfunction after Myocardial Infarction. Køber, Lars; Torp-Pedersen, Christian; Carlsen, Jan E.; Bagger, Henning; Eliasen, Per; Lyngborg, Kjeld; Videbæk, Jørgen; Cole, David S.; Auclert, Laurent; Pauly, Nancy C.; Aliot, Etienne; Persson, Stig; Camm, A. John // New England Journal of Medicine;12/21/95, Vol. 333 Issue 25, p1670 

    Background: Treatment with angiotensin-converting–enzyme (ACE) inhibitors reduces mortality among survivors of acute myocardial infarction, but whether to use ACE inhibitors in all patients or only in selected patients is uncertain. Methods: We screened 6676 consecutive patients with 7001...

  • Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock. Hochman, Judith S.; Sleeper, Lynn A.; Webb, John G.; Sanborn, Timothy A.; White, Harvey D.; Talley, J. David; Buller, Christopher E.; Jacobs, Alice K.; Slater, James N.; Col, Jacques; McKinlay, Sonja M.; Picard, Michael H.; Menegus, Mark A.; Boland, Jean; Dzavik, Vladimir; Thompson, Christopher R.; Wong, S. Chiu; Steingart, Richard; Forman, Robert; Aylward, Philip E. // New England Journal of Medicine;08/26/99, Vol. 341 Issue 9, p625 

    Background: The leading cause of death in patients hospitalized for acute myocardial infarction is cardiogenic shock. We conducted a randomized trial to evaluate early revascularization in patients with cardiogenic shock. Methods: Patients with shock due to left ventricular failure complicating...

  • Increasing incidence and mortality from myocardial infarction in Stockholm county. Alfredsson, Lars; Ahlbom, Anders // British Medical Journal (Clinical Research Edition);6/18/1983, Vol. 286 Issue 6382, p1931 

    Reports the increase in the incidence and mortality from myocardial infarction in Stockholm, Sweden. Obtainment of information on patients at risk; Basis for describing the trends of the disease; Lack of reasoning on the increase incidence and mortality of the disease.

  • Review: PTCA reduces adverse cardiac outcomes and death better than thrombolytics after myocardial infarction. Keeley, E. C.; Boura, J. A.; Grines, C. L. // Evidence Based Medicine;Jul2003, p108 

    The article presents a research that compares the effectiveness of percutaneous transluminal coronary angioplasty (PTCA) and thrombolytic treatment in preventing death and adverse cardiac effects of acute myocardial infarction (MI) patients in the U.S. Researchers compared results of randomized...

  • Moderate alcohol consumption before and after heart attack associated with lower mortality.  // Biomedical Market Newsletter;4/21/2012, Vol. 21, p1 

    The article focuses on a follow-up study, according to which men who consumed alcohol moderately before and after heart attacks were associated with lower mortality.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics