Seizures and epilepsy in oncological practice: causes, course, mechanisms and treatment

Singh, Gagandeep; Rees, Jeremy H.; Sander, Josemir W.
April 2007
Journal of Neurology, Neurosurgery & Psychiatry;Apr2007, Vol. 78 Issue 4, p342
Academic Journal
There are few data available on the causes and mechanistic basis, outcome and treatment of seizures and epilepsy in people with systemic cancer. Seizures and epilepsy in people with cancers other than primary brain tumours are reviewed here. Articles published in English, which discussed the neurological manifestations and complications of cancer and its treatment, were searched and information on the frequency, aetiology, and course of seizures and epilepsy was extracted. The frequency, aetiology and outcome of seizure disorders in patients with cancer differ from those in the general population. Intracranial metastasis, cancer drugs and metabolic disturbances are the most common causes. Infections, cerebrovascular complications of systemic cancer and paraneoplastic disorders are among the rarer causes of seizures in patients with neoplasms. Several drugs used in the treatment of cancer, or complications arising from their use, can trigger seizures through varied mechanisms. Most drug-induced seizures are provoked and do not require long-term treatment with antiepileptic drugs.


Related Articles

  • Comprehensive Epilepsy Review for Primary Care. Hasegawa, Hisanori; Simkins, Robert T. // Primary Care Reports;Nov2008, Vol. 14 Issue 11, p117 

    The article offers clinical information on epilepsy. Epilepsy refers to the propensity to have recurrent seizure attacks. Its causes widely vary, including genetic abnormalities congenital brain anomaly and brain trauma. In diagnosing epilepsy, differentiating non-epileptic phenomena is...

  • epilepsy.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p791 

    An encyclopedia entry for the medical term "epilepsy" is presented. It refers to a disease characterized by recurrent seizures and is found in roughly 2 or 3 percent of the population. It is categorized by the International League Against Epilepsy as either partial, generalized, or unclassified....

  • Research Highlights. Basson, Michael; Bhatia, Jasmine; Chmielnicki, Eva; Farrell, Alison; Schubert, Charlotte // Nature Medicine;Apr2006, Vol. 12 Issue 4, p394 

    The article cites studies on etiology and treatment of various diseases. A rare form of epilepsy may be caused by defects in a protein that controls potassium channel closing during neuron firing. Collapsin response mediator proteins are best known as mediators of axon guidance, but some groups...

  • Refractory status epilepticus. Singhal, Ankit; Tripathi, Manjari // Neurology Asia;Mar2013 Supplement, Vol. 18 Issue S1, p67 

    Status epilepticus is a life threatening neurological emergency. In persons with status epilepticus, if administration of a benzodiazepine and at least one antiepileptic drug has failed then management protocols for refractory status epilepticus should be put into effect. The article summarises...

  • Epilepsy. Thakkar, Raj // Nursery World (Haymarket Business Publications Ltd);6/11/2012, Vol. 112 Issue 4295, p30 

    The article offers information on the different types of epilepsy, its causes, treatment and management. It differentiates between focal epilepsy and generalized seizures. The causes of secondary epilepsy, atomic seizures, childhood absence epilepsy, continuous spike and wave during slow sleep...

  • Literature Review.  // Current Medical Literature: Epilepsy Monitor;2003, Vol. 7 Issue 3, p50 

    Provides information concerning epilepsy. Drug resistance; Neuronal death; Genesis of epilepsy; Mechanism of generation of the high frequency activity that precedes or occurs during seizures; Effect of seizures on the brain; Anti-epileptic drugs; Contribution of environment and inheritance to...

  • Out-of-body experiences associated with seizures. Greyson, Bruce; Fountain, Nathan B.; Derr, Lori L.; Broshek, Donna K. // Frontiers in Human Neuroscience;Feb2014, Vol. 8, p1 

    Alterations of consciousness are critical factors in the diagnosis of epileptic seizures. With these alterations in consciousness, some persons report sensations of separating from the physical body, experiences that may in rare cases resemble spontaneous out-of-body experiences. This study was...

  • SYMPTOMATIC EPILEPSY. TATUM IV, WILLIAM O.; KAPLAN, PETER W.; JALLON, PIERRE // Epilepsy A to Z: A Concise Encyclopedia;2009, p329 

    An encyclopedia entry for "symptomatic epilepsy" is presented. It refers to an acquired kind of epilepsy caused by an underlying identifiable etiology. It notes that these epilepsy may be caused by lesions such as those obtained from trauma, brain tumor or stroke. It is also characterized by...

  • Síndromes epilépticos en la infancia. Alva-Moncayo, Edith // Revista Medica del IMSS;ene/feb2011, Vol. 49 Issue 1, p37 

    No abstract available.


Read the Article


Sign out of this library

Other Topics