TITLE

IMMUNOPATHOGENESIS OF IBD: INSUFFICIENT SUPPRESSOR FUNCTION IN THE GUT?

AUTHOR(S)
Huibregtse, I. L.; Van Lent, A. U.; Van Deventer, S. J. H.
PUB. DATE
April 2007
SOURCE
Gut;Apr2007, Vol. 56 Issue 4, p584
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article offers insights into evidence for abnormal regulation of T cell activation in Crohn's disease, as well as data concerning the existence and functional activity of regulatory T cells in the intestinal mucosa. Regulatory T cells have important functions in suppressing unwanted inflammatory responses towards self antigens and the antigens of endogenous intestinal bacteria. The article also considers the potential therapeutic application of Treg in inflammatory bowel diseases.
ACCESSION #
24767590

 

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